-
公开(公告)号：EP0836616A1
公开(公告)日：1998-04-22
申请号：EP96924886.0
申请日：1996-07-04
发明人： FEHR, Theodor , OBERER, Lukas , QUESNIAUX RYFFEL, Valerie , SANGLIER, Jean-Jacques , SCHULER, Walter , SEDRANI, Richard
IPC分类号： C12P21 , A61K31 , A61P29 , A61P37 , C07D309 , C07D491 , C07D498 , C07D519 , C07K5 , C12N1 , A61K38 , C12R1
CPC分类号： C07D491/10 , A61K38/00 , C07D309/10 , C07D309/30 , C07K5/06052 , C12R1/465
摘要： A novel class of macrolides in which i) positions 2 to 6 inclusive of the macrocyclic ring are provided by a piperidazinyl carboxylic acid residue; and/or ii) positions 7 to 9 inclusive of the macrocyclic ring are provided by an aromatic α-amino acid residue; and/or iii) positions 10 to 12 inclusive of the macrocyclic ring are provided by an aliphatic α-amino acid residue, preferably comprising two, or especially all three of the characteristic structural features i), ii) and iii), more especially a compound of formula (IX) is provided having immunosuppressant and anti-inflammatory properties and protected and ring-open forms thereof.
-
公开(公告)号：EP1581536A2
公开(公告)日：2005-10-05
申请号：EP03785920.4
申请日：2003-12-22
申请人： Novartis AG , Novartis Pharma GmbH
发明人： DENNI-DISCHERT, Donatienne , FLOERSHEIMER, Andreas , KÜSTERS, Ernst , OBERER, Lukas , SEDELMEIER, Gottfried
IPC分类号： C07D493/04 , C07D417/06 , A61K31/427 , A61P35/00 , C07C59/90
CPC分类号： C07D417/06 , C07C59/215 , C07D493/04
摘要： The present invention relates to C4-demethyl-epothilones or C4-bisnor-epothilones of Formula (I), their pharmaceutical use, pharmaceutical composition containing the same and methods for their preparation.
摘要翻译： 本发明涉及式（I）的C4-去甲基 - 埃坡霉素或C4-二去甲 - 埃坡霉素，它们的药物用途，含有其的药物组合物及其制备方法。
-
公开(公告)号：EP1675817A1
公开(公告)日：2006-07-05
申请号：EP04790423.0
申请日：2004-10-14
申请人： Novartis AG , Novartis Pharma GmbH
IPC分类号： C07C215/28 , C07C233/22 , A61K31/135 , A61P37/00
CPC分类号： A61K31/137 , A61K31/135 , A61K45/06 , C07C215/28 , C07C233/22 , A61K2300/00
摘要： Disclosed are compounds of formula (I) wherein R1, R2, R5 and R6 are as defined in the claims; such compounds have interesting pharmacological properties.
摘要翻译： 公开了式（I）的化合物，其中R 1，R 2，R 5和R 6如权利要求中所定义; 这样的化合物具有有趣的药理学性质
-
公开(公告)号：EP3018121A1
公开(公告)日：2016-05-11
申请号：EP15185231.6
申请日：2004-10-14
申请人： Novartis AG
IPC分类号： C07C215/28 , C07C233/22 , A61K31/135 , A61P37/00
CPC分类号： A61K31/137 , A61K31/135 , A61K45/06 , C07C215/28 , C07C233/22 , A61K2300/00
摘要： Disclosed are compounds of formula I
wherein R 1 , R 2 , R 5 and R 6 are as defined in the claims; such compounds have interesting pharmacological properties.摘要翻译： 公开了式I化合物，其中R 1，R 2，R 5和R 6如权利要求中所定义; 这样的化合物具有有趣的药理学性质
-
公开(公告)号：EP1675817B1
公开(公告)日：2015-10-14
申请号：EP04790423.0
申请日：2004-10-14
申请人： Novartis AG
IPC分类号： C07C215/28 , C07C233/22 , A61K31/135 , A61P37/00
CPC分类号： A61K31/137 , A61K31/135 , A61K45/06 , C07C215/28 , C07C233/22 , A61K2300/00
-
-
-
-
搜索结果
5 条记录 (耗时 0.014 秒)
