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公开(公告)号：EP1117403A1
公开(公告)日：2001-07-25
申请号：EP99948905.7
申请日：1999-09-30
发明人： ALLGEIER, Hans , COSFORD, Nicholas, David , FLOR, Peter, Josef , GASPARINI, Fabrizio , GENTSCH, Conrad , HESS, Stephen, D. , JOHNSON, Edwin, Carl , KUHN, Rainer , TRICKLEBANK, Mark , URBAN, Laszlo , VARNEY, Mark, Andrew , VELI ELEBI, Gönül , WALKER, Katharine
CPC分类号： A61K31/44
摘要： The invention provides the use of selective mGluR5 antagonists for the treatment of pain and anxiety, and the use of mGluR antagonists for the treatment of pain, whereby analgesic effect is achieved by interaction of said antagonists primarily or predominantly at peripheral mGluR receptors.
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公开(公告)号：EP0998459A2
公开(公告)日：2000-05-10
申请号：EP98941308.3
申请日：1998-07-09
发明人： ALLGEIER, Hans , AUBERSON, Yves , BIOLLAZ, Michel , COSFORD, Nicholas, David , GASPARINI, Fabrizio , HECKENDORN, Roland , JOHNSON, Edwin, Carl , KUHN, Rainer , VARNEY, Mark, Andrew , VELICELEBI, Gönül
IPC分类号： C07D213/00
CPC分类号： C07D213/06 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/50 , C07D213/52 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/89 , C07D215/12 , C07D401/06 , C07D401/10 , C07D405/06 , C07D409/06 , C07F7/0812
摘要： Compounds of the formula (I), wherein X and R1 to R5 are as defined in the description, are useful for treating disorders mediated full or in part by mGluR5.
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公开(公告)号：EP1117403B1
公开(公告)日：2003-12-10
申请号：EP99948905.7
申请日：1999-09-30
发明人： ALLGEIER, Hans , COSFORD, Nicholas, David , FLOR, Peter, Josef , GASPARINI, Fabrizio , GENTSCH, Conrad , HESS, Stephen, D. , JOHNSON, Edwin, Carl , KUHN, Rainer , TRICKLEBANK, Mark , URBAN, Laszlo , VARNEY, Mark, Andrew , VELI ELEBI, Gönül , WALKER, Katharine
CPC分类号： A61K31/44
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公开(公告)号：EP0998459B1
公开(公告)日：2008-04-23
申请号：EP98941308.3
申请日：1998-07-09
发明人： ALLGEIER, Hans , AUBERSON, Yves , BIOLLAZ, Michel , COSFORD, Nicholas, David , GASPARINI, Fabrizio , HECKENDORN, Roland , JOHNSON, Edwin, Carl , KUHN, Rainer , VARNEY, Mark, Andrew , VELICELEBI, Gönül
IPC分类号： C07D213/00
CPC分类号： C07D213/06 , C07D213/16 , C07D213/26 , C07D213/30 , C07D213/50 , C07D213/52 , C07D213/53 , C07D213/55 , C07D213/56 , C07D213/57 , C07D213/65 , C07D213/74 , C07D213/79 , C07D213/80 , C07D213/81 , C07D213/82 , C07D213/84 , C07D213/89 , C07D215/12 , C07D401/06 , C07D401/10 , C07D405/06 , C07D409/06 , C07F7/0812
摘要： Compounds of the formula (I), wherein X and R1 to R5 are as defined in the description, are useful for treating disorders mediated full or in part by mGluR5.
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5.发明授权HUMAN METABOTROPIC GLUTAMATE RECEPTOR SUBTYPE HMGLUR7 AND RELATED DNA COMPOUNDS 失效人类METABO热带型谷氨酸受体在TYPE HMGLUR7及相关DNS连接
公开(公告)号：EP0720650B1
公开(公告)日：2004-12-01
申请号：EP94926247.1
申请日：1994-09-07
申请人： Novartis AG , Novartis Pharma GmbH
CPC分类号： C07K16/286 , C07K14/70571 , C07K2319/00 , C12Q1/6876 , C12Q2600/136
摘要： The present invention relates to human metabotropic glutamate receptor (hmGluR) proteins, isolated nucleic acids coding therefor, host cells producing the proteins of the invention, methods for the preparation of such proteins, nucleic acids and host cells, and uses thereof. Furthermore, the invention provides antibodies directed against the hmGluR proteins.
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