公开(公告)号：EP3589647A1

公开(公告)日：2020-01-08

申请号：EP18710717.2

申请日：2018-02-28

申请人： Novartis AG ,  The Trustees of The University of Pennsylvania

发明人： ALBELDA, Steven, M. ,  MOON, Edmund, K.

IPC分类号： C07K14/705 ,  A61K35/17 ,  C12N5/0783 ,  C12N9/16

公开(公告)号：EP1061806A1

公开(公告)日：2000-12-27

申请号：EP99911363.2

申请日：1999-03-12

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： MOLNAR-KIMBER, Katherine, L. ,  CAPARRELLI, David J. ,  KAISER, Larry, R. ,  ALBELDA, Steven, M. ,  COUKOS, George

IPC分类号： A01N63/00 ,  C12N1/20 ,  C12N15/00 ,  C12P21/06

CPC分类号： A61K48/00 ,  A61K35/763 ,  C12N2710/16632

摘要： The invention includes producer cells for administering to a subject having tumor cells in order to kill tumor cells or prevent growth or spread of the tumor. The producer cell comprises an oncolytic virus which is capable of replicating in the producer cell. The producer cell is not capable of sustained survival in the body of the subject. The invention also includes methods of using these producer cells to treat a subject having tumor cells and making a medicament for use in such treatment.

公开(公告)号：EP2227691B1

公开(公告)日：2012-10-31

申请号：EP08859692.9

申请日：2008-12-05

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  The Trustees of the University of Pennsylvania

发明人： SHOWE, Michael ,  SHOWE, Louise ,  YOUSEF, Malik ,  ALBELDA, Steven, M. ,  VACHANI, Anil ,  KOSSENKOV, Andrei V.

IPC分类号： G01N33/48

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16

公开(公告)号：EP2737317A2

公开(公告)日：2014-06-04

申请号：EP12746193.7

申请日：2012-07-27

申请人： The Trustees Of The University Of Pennsylvania ,  Veridex, LLC

发明人： RAO, Galla, Chandra ,  FOULK, Brad ,  ALBELDA, Steven, M. ,  SCHWED, Daniel ,  CONNELLY, Mark

IPC分类号： G01N33/574 ,  G01N15/00

CPC分类号： G01N33/574 ,  C12Q1/6841 ,  G01N1/40 ,  G01N1/4077 ,  G01N33/57488 ,  G01N2333/705

摘要： A method for diagnosing or differentially diagnosing a cancer characterized by the presence of cancer cells in the pleural fluid of a mammalian subject, the method comprising contacting a sample of pleural fluid of the subject with colloidal magnetic particles coupled to a ligand which binds to a determinant on a cancer cell, but does not bind above a baseline threshold to other cellular and non-cellular components in pleural fluid; subjecting the pleural fluid-magnetic particle mixture to a magnetic field to produce a cell fraction enriched in ligand coupled-magnetic particle-bound cancer cells, if present in the pleural fluid; and analyzing the enriched fraction for the number of cancer cells in the pleural fluid. In certain aspects, this method involves preparing the pleural fluids for the above-noted method steps by, e.g., dilution of unprocessed pleural fluid. In certain aspect, the pleural fluid is subjected to the diagnostic method within 24 hours of withdrawal from the subject. This method has advantages to present diagnostic procedures for identifying malignant pleural effusions. The tumor cells present in pleural fluid can be characterized with cellular and molecular markers to determine prognostic and predictive factors.

公开(公告)号：EP2227691A2

公开(公告)日：2010-09-15

申请号：EP08859692.9

申请日：2008-12-05

申请人： THE WISTAR INSTITUTE OF ANATOMY AND BIOLOGY ,  The Trustees of the University of Pennsylvania

发明人： SHOWE, Michael ,  SHOWE, Louise ,  YOUSEF, Malik ,  ALBELDA, Steven, M. ,  VACHANI, Anil ,  KOSSENKOV, Andrei V.

IPC分类号： G01N33/48

CPC分类号： G01N33/57423 ,  C12Q1/6886 ,  C12Q2600/112 ,  C12Q2600/118 ,  C12Q2600/158 ,  C12Q2600/16

摘要： Methods and compositions are provided for diagnosing lung cancer in a mammalian subject by use of three or more selected genes, e g, a gene expression profile, from the peripheral blood mononuclear cells (PBMC) of the subject Detection of changes in expression in the selected genes forming the gene expression profile from that of a reference gene expression profile are correlated with non-small cell lung cancer (NSCLC).

公开(公告)号：EP1064026A1

公开(公告)日：2001-01-03

申请号：EP99912398.7

申请日：1999-03-10

申请人： THE TRUSTEES OF THE UNIVERSITY OF PENNSYLVANIA

发明人： MUZYKANTOV, Vladimir, R. ,  ALBELDA, Steven, M.

IPC分类号： A61K39/395 ,  G01N33/53

CPC分类号： C07K16/2803 ,  A61K47/6898 ,  B82Y5/00 ,  C07K2317/77

摘要： A method for enhancing intracellular delivery of effector molecules is provided. The method involves modifying selected antibodies with biotin and streptavidin, conjugating these antibodies with an effector molecule, and delivering the conjugated effector to an intracellular target specifically recognized by the antibody.