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1.发明公开
公开(公告)号：EP4056588A1
公开(公告)日：2022-09-14
申请号：EP22162298.8
申请日：2016-04-08
发明人： BITTER, Hans , BORDEAUX, Jennifer Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl H. , KIM, Ju Young , LEI, Ming , LI, Na , LOEW, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783 , A61K39/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
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2.发明公开CD20 THERAPIES, CD22 THERAPIES, AND COMBINATION THERAPIES WITH A CD19 CHIMERIC ANTIGEN RECEPTOR (CAR) - EXPRESSING CELL 审中-公开CD20疗法，CD22疗法和与CD19嵌合抗原接受者（CAR）的组合疗法 - 表达细胞
公开(公告)号：EP3280729A2
公开(公告)日：2018-02-14
申请号：EP16719611.2
申请日：2016-04-08
发明人： BITTER, Hans , BORDEAUX, Jennifer, Mary , BRANNETTI, Barbara , BROGDON, Jennifer , DAKAPPAGARI, Naveen, Kumar , GILL, Saar , HIGHFILL, Steven , HUANG, Lu , JUNE, Carl, H. , KIM, Ju, Young , LEI, Ming , LI, Na , LOEW, Andreas , ORLANDO, Elena , RUELLA, Marco , TRAN, Thai , ZHANG, Jimin , ZHOU, Li
IPC分类号： C07K14/725 , C07K16/28 , C12N5/0783 , A61K39/00
CPC分类号： C07K14/70596 , A61K38/00 , A61K39/0011 , A61K45/06 , A61K2039/5156 , A61K2039/5158 , A61K2039/70 , C07K14/7051 , C07K16/2803 , C07K16/2866 , C07K2317/24 , C07K2317/622 , C07K2319/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with one or more B-cell inhibitors, e.g., inhibitors of one or more of CD10, CD20, CD22, CD34, CD123, FLT-3, ROR1, CD79b, CD179b, or CD79a. The disclosure additionally features novel antigen binding domains and CAR molecules directed to CD20 and CD22, and uses, e.g., as monotherapies or in combination therapies. The invention also provides kits and compositions described herein.
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公开(公告)号：EP3183268B1
公开(公告)日：2020-02-12
申请号：EP15756525.0
申请日：2015-08-19
发明人： KENDERIAN, Saad , BROGDON, Jennifer , GILL, Saar , GLASS, David , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , PORTER, David L. , RUELLA, Marco , WANG, Yongqiang , WU, Qilong , ZHANG, Jiquan
IPC分类号： C07K16/28 , A61K39/395
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4.发明公开
公开(公告)号：EP3490590A2
公开(公告)日：2019-06-05
申请号：EP17755330.2
申请日：2017-08-01
发明人： GILL, Saar , RUELLA, Marco , KLICHINSKY, Michael
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5.发明公开TREATMENT OF CANCER USING ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR 审中-公开TOR UNG ON ON BS TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR
公开(公告)号：EP3129470A1
公开(公告)日：2017-02-15
申请号：EP15719043.0
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl, H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David, L. , RUELLA, Marco , SELLERS, William, Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： C12N5/0783 , A61K35/17 , A61K31/00 , A61P35/02
CPC分类号： A61K35/17 , A61K31/436 , A61K31/519 , A61K31/53 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K16/2803 , C07K2317/14 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C12N5/0636 , C12N2501/599 , C12N2501/727 , C12N2510/00 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
摘要翻译： 本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过如本文所述施用包含本文所述的CD19 CAR的重组T细胞与激酶抑制剂，例如本文所述的激酶抑制剂组合。 本发明还提供了本文所述的试剂盒和组合物。
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公开(公告)号：EP4406610A2
公开(公告)日：2024-07-31
申请号：EP24166976.1
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61P35/02
CPC分类号： C12N5/0636 , C12N2501/72720130101 , C07K16/2803 , A61K31/519 , A61K45/06 , A61K31/436 , A61K31/53 , C07K2317/62220130101 , C07K2319/0320130101 , C07K2317/7320130101 , A61P35/00 , A61P35/02 , A61P43/00 , A61K39/001112 , A61K2239/3820230501 , A61K39/4631 , A61K2239/2620230501 , A61K2239/4820230501 , A61K39/464412 , A61K2239/3120230501 , A61K39/4611 , A61K39/4636
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：EP3888674A1
公开(公告)日：2021-10-06
申请号：EP21160203.2
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61K39/00 , A61K35/17 , A61K31/436 , A61P35/02
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：EP4406610A3
公开(公告)日：2024-10-30
申请号：EP24166976.1
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61K39/00 , A61K35/17 , A61K31/436 , A61P35/02
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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9.发明公开COMBINATION OF CHIMERIC ANTIGEN RECEPTOR THERAPY AND AMINO PYRIMIDINE DERIVATIVES 审中-公开嵌合抗原受体疗法与氨基嘧啶衍生物的组合
公开(公告)号：EP3280795A1
公开(公告)日：2018-02-14
申请号：EP16718786.3
申请日：2016-04-07
申请人： Novartis AG , The Trustees of The University of Pennsylvania , Byrd, John , Dubovsky, Jason , Johnson, Amy , June, Carl, H. , Muthusamy, Natarajan , Porter, David L. , Wasik, Mariusz
发明人： BYRD, John , DUBOVSKY, Jason , JOHNSON, Amy , JUNE, Carl, H. , MUTHUSAMY, Natarajan , PORTER, David, L. , WASIK, Mariusz , ANGST, Daniela , FRAIETTA, Joseph, A. , GESSIER, Francois , GILL, Saar , MAUS, Marcela , RUELLA, Marco , VULPETTI, Anna
IPC分类号： C12N5/0783 , A61K31/505 , A61K31/506 , A61K45/06
CPC分类号： A61K31/505 , A61K31/506 , A61K35/17 , A61K45/06 , A61K2035/124 , A61K2039/505 , A61K2039/545 , A61P35/00 , A61P35/02 , C07K16/2803 , C07K16/30 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N5/0636 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a BTK inhibitor, e.g., an amino pyrimidine derivative described herein. The invention also provides kits and compositions described herein.
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10.发明公开
公开(公告)号：EP3172237A2
公开(公告)日：2017-05-31
申请号：EP15753519.6
申请日：2015-07-21
发明人： BROGDON, Jennifer , CHOI, Eugene , EBERSBACH, Hilmar , GLASS, David , HUET, Heather , JUNE, Carl H. , MANNICK, Joan , MILONE, Michael C. , MURPHY, Leon , PLESA, Gabriela , RICHARDSON, Celeste , RUELLA, Marco , SINGH, Reshma , WANG, Yongqiang , WU, Qilong
CPC分类号： C07K14/705 , A61K35/12 , A61K38/177 , C07K16/2878 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
摘要翻译： 本发明提供了用于治疗与BCMA表达相关的疾病的组合物和方法。 本发明还涉及对编码BCMA载体的BCMA载体特异性的嵌合抗原受体（CAR）和包含BCMA CAR的重组T细胞。 本发明还包括施用表达包含BCMA结合结构域的CAR的遗传修饰的T细胞的方法。
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