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1.发明公开COMBINATIONS OF LOW, IMMUNE ENHANCING. DOSES OF MTOR INHIBITORS AND CARS 审中-公开低，免疫增强的组合。 MTOR抑制剂和汽车的剂量
公开(公告)号：EP3193915A1
公开(公告)日：2017-07-26
申请号：EP15753232.6
申请日：2015-07-21
IPC分类号： A61K39/00 , A61K31/4745
CPC分类号： A61K45/06 , A61K31/436 , A61K31/4745 , A61K31/5377 , A61K39/00 , A61K2039/55511 , A61K2300/00
摘要： The invention relates, in part, to a method of treating a subject comprising administering to the subject a low, immune enhancing of a mTOR inhibitor and an immune effector cell engineered to expres a CAR.
摘要翻译： 本发明部分涉及治疗受试者的方法，其包括向受试者施用mTOR抑制剂和工程化表达CAR的免疫效应细胞的低免疫增强。
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2.发明公开
公开(公告)号：EP3172234A1
公开(公告)日：2017-05-31
申请号：EP15745069.3
申请日：2015-07-21
发明人： KENDERIAN, Saad , BROGDON, Jennifer , EBERSBACH, Hilmar , GILL, Saar , GLASS, David , HUBER, Thomas , JASCUR, Julia , MANNICK, Joan , MILONE, Michael C. , MURPHY, Leon , RICHARDSON, Celeste , SINGH, Reshma , SONG, Huijuan , WU, Qilong , ZHANG, Jiquan
IPC分类号： C07K16/28 , C07K16/30 , C07K14/725 , C07K14/705 , A61K39/395 , A61K31/436 , A61K35/17 , A61P35/02
CPC分类号： C07K16/2851 , A61K31/436 , A61K31/711 , A61K35/28 , A61K38/00 , A61K38/1774 , A61K38/1793 , A61K39/39558 , A61K45/06 , A61K48/00 , A61K2039/505 , A61K2039/5156 , C07K14/7051 , C07K14/70517 , C07K14/7056 , C07K14/70578 , C07K14/7151 , C07K16/2803 , C07K16/30 , C07K16/3061 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/53 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/00 , C07K2319/03 , C07K2319/33 , C07K2319/70 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD33. The invention also relates to chimeric antigen receptor (CAR) specific to CD33, vectors encoding the same, and recombinant T cells comprising the CD33 CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD33 binding domain.
摘要翻译： 本发明提供用于治疗与CD33表达相关的疾病的组合物和方法。 本发明还涉及对CD33特异性的嵌合抗原受体（CAR），编码它的载体和包含CD33 CAR的重组T细胞。 本发明还包括施用基因修饰的表达包含CD33结合结构域的CAR的T细胞的方法。
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公开(公告)号：EP4420663A3
公开(公告)日：2024-10-30
申请号：EP24173692.5
申请日：2014-12-19
发明人： BROGDON, Jennifer , ENGELS, Boris , GLASS, David Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , SELLERS, William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
IPC分类号： C07K19/00 , C12N5/0783 , A61K31/436 , A61K35/17 , C07K14/725 , C07K16/28
摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
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公开(公告)号：EP4406610A3
公开(公告)日：2024-10-30
申请号：EP24166976.1
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61K39/00 , A61K35/17 , A61K31/436 , A61P35/02
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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5.发明公开
公开(公告)号：EP3172237A2
公开(公告)日：2017-05-31
申请号：EP15753519.6
申请日：2015-07-21
发明人： BROGDON, Jennifer , CHOI, Eugene , EBERSBACH, Hilmar , GLASS, David , HUET, Heather , JUNE, Carl H. , MANNICK, Joan , MILONE, Michael C. , MURPHY, Leon , PLESA, Gabriela , RICHARDSON, Celeste , RUELLA, Marco , SINGH, Reshma , WANG, Yongqiang , WU, Qilong
CPC分类号： C07K14/705 , A61K35/12 , A61K38/177 , C07K16/2878 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/92 , C07K2319/00 , C07K2319/30
摘要： The invention provides compositions and methods for treating diseases associated with expression of BCMA. The invention also relates to chimeric antigen receptor (CAR) specific to BCMA vectors encoding the same, and recombinant T cells comprising the BCMA CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises a BCMA binding domain.
摘要翻译： 本发明提供了用于治疗与BCMA表达相关的疾病的组合物和方法。 本发明还涉及对编码BCMA载体的BCMA载体特异性的嵌合抗原受体（CAR）和包含BCMA CAR的重组T细胞。 本发明还包括施用表达包含BCMA结合结构域的CAR的遗传修饰的T细胞的方法。
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公开(公告)号：EP3171882A1
公开(公告)日：2017-05-31
申请号：EP15744448.0
申请日：2015-07-21
发明人： KENDERIAN, Saad , BROGDON, Jennifer , EBERSBACH, Hilmar , GILL, Saar , GLASS, David , JASCUR, Julia , MANNICK, Joan , MILONE, Michael, C. , MURPHY, Leon , RICHARDSON, Celeste , SINGH, Reshma , WEI, Lai , WU, Qilong , YANG, Qiumei , ZHANG, Jiquan
IPC分类号： A61K35/17 , C07K14/725 , C07K16/28
CPC分类号： A61K39/0011 , A61K31/7068 , A61K35/17 , A61K45/06 , A61K2039/5156 , C07K14/7051 , C07K14/70578 , C07K16/2851 , C07K2317/622 , C07K2319/02 , C07K2319/03
摘要： The invention provides compositions and methods for treating diseases associated with expression of CLL-1. The invention also relates to chimeric antigen receptor (CAR) specific to CLL-1, vectors encoding the same, and recombinant cells comprising the CLL-1 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CLL-1 binding domain.
摘要翻译： 本发明提供了用于治疗与CLL-1表达相关的疾病的组合物和方法。 本发明还涉及对CLL-1特异性的嵌合抗原受体（CAR），编码它的载体和包含CLL-1 CAR的重组细胞。 本发明还包括施用表达包含CLL-1结合结构域的CAR的基因修饰细胞的方法。
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公开(公告)号：EP3712171A1
公开(公告)日：2020-09-23
申请号：EP19219069.2
申请日：2015-08-19
发明人： KENDERIAN, Saad , BROGDON, Jennifer , GILL, Saar , GLASS, David , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , PORTER, David L , RUELLA, Marco , WANG, Yongqiang , WU, Qilong , ZHANG, Jiquan
IPC分类号： C07K16/28 , A61K39/395
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
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公开(公告)号：EP3172234B1
公开(公告)日：2020-04-08
申请号：EP15745069.3
申请日：2015-07-21
发明人： KENDERIAN, Saad , BROGDON, Jennifer , EBERSBACH, Hilmar , GILL, Saar , GLASS, David , HUBER, Thomas , JASCUR, Julia , MANNICK, Joan , MILONE, Michael C. , MURPHY, Leon , RICHARDSON, Celeste , SINGH, Reshma , SONG, Huijuan , WU, Qilong , ZHANG, Jiquan
IPC分类号： C07K16/28 , C07K16/30 , C07K14/725 , C07K14/705 , A61K39/395 , A61K31/436 , A61K35/17 , A61P35/02
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9.发明公开ANTI-CD123 CHIMERIC ANTIGEN RECEPTOR (CAR) FOR USE IN CANCER TREATMENT 审中-公开抗癌CD123嵌合抗原受体（CAR）用于癌症治疗
公开(公告)号：EP3183268A1
公开(公告)日：2017-06-28
申请号：EP15756525.0
申请日：2015-08-19
发明人： KENDERIAN, Saad , BROGDON, Jennifer , GILL, Saar , GLASS, David , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , PORTER, David L. , RUELLA, Marco , WANG, Yongqiang , WU, Qilong , ZHANG, Jiquan
IPC分类号： C07K16/28 , A61K39/395
CPC分类号： C07K16/2866 , A61K39/0011 , A61K2039/505 , A61K2039/507 , A61K2039/5156 , C07K16/244 , C07K2317/24 , C07K2317/622 , C07K2317/73 , C07K2317/76 , C07K2319/03 , C07K2319/33 , C12N5/0636
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD123. The invention also relates to chimeric antigen receptor (CAR) specific to CD123, vectors encoding the same, and recombinant cells comprising the CD123 CAR. The invention also includes methods of administering a genetically modified cell expressing a CAR that comprises a CD123 binding domain.
摘要翻译： 本发明提供了用于治疗与CD123表达相关的疾病的组合物和方法。 本发明还涉及对CD123特异性的嵌合抗原受体（CAR），编码CD123的载体和包含CD123 CAR的重组细胞。 本发明还包括施用表达包含CD123结合结构域的CAR的基因修饰细胞的方法。
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公开(公告)号：EP4420663A2
公开(公告)日：2024-08-28
申请号：EP24173692.5
申请日：2014-12-19
发明人： BROGDON, Jennifer , ENGELS, Boris , GLASS, David Jonathan , GRANDA, Brian , HASTEWELL, John , LOEW, Andreas , MANNICK, Joan , MILONE, Michael , MURPHY, Leon , SELLERS, William Raj , SONG, Huijuan , VASH, Brian Edward , WEILER, Jan , WU, Qilong , ZHOU, Li
IPC分类号： A61K31/436
CPC分类号： C07K14/7051 , C07K14/70521 , C07K14/70539 , C07K14/70578 , C12N9/90 , C07K2319/0020130101 , C07K2319/0320130101 , C07K2319/7020130101 , C12N9/1205 , C07K2319/4120130101 , C07K2319/4320130101 , A61K31/436 , C12Y502/00 , A61P35/00 , A61P37/04 , A61K39/464468 , A61K2239/2420230501 , A61K2239/4820230501 , A61K39/4631 , A61K39/464404 , A61K2239/2320230501 , A61K39/4611 , A61K2239/3820230501 , A61K39/464412
摘要： Compositions and methods relating to regulatable chimeric antigen receptors (RCARs), where the intracellular signaling or proliferation of the RCAR can be controlled to optimize the use of an RCAR-expressing cell to provide an immune response, are provided. For example, a RCAR can comprise a dimerization switch that, upon the presence of a dimerization molecule, can couple an intracellular signaling domain to an extracellular recognition element, e.g., an antigen binding domain, an inhibitory counter ligand binding domain, or costimulatory ECD domain. An RCAR can be engineered to include an appropriate antigen binding domain that is specific to a desired antigen target and used in the treatment of a disease.
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