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公开(公告)号：EP2970482B1
公开(公告)日：2019-03-06
申请号：EP14722469.5
申请日：2014-03-15
IPC分类号： C07K16/28 , A61K35/14 , C07K14/725 , C07K14/705 , C07K16/30 , C12N5/0783 , A61P35/00
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2.发明公开TREATMENT OF CANCER USING HUMANIZED ANTI-EGFRVIII CHIMERIC ANTIGEN RECEPTOR 审中-公开百日咳ON BS BS IT IT IT TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR
公开(公告)号：EP2958943A1
公开(公告)日：2015-12-30
申请号：EP14713280.7
申请日：2014-02-20
申请人： The Trustees of The University of Pennsylvania , University of Pittsburgh - Of the Commonwealth System of Higher Education , Novartis AG
发明人： BROGDON, Jennifer , LOEW, Andreas , JOHNSON, Laura Alexandra , JUNE, Carl H. , MAUS, Marcela , SCHOLLER, John , OKADA, Hideho
CPC分类号： C07K16/2863 , A61K35/17 , A61K38/00 , A61K2039/505 , C07K16/3053 , C07K2317/21 , C07K2317/24 , C07K2317/34 , C07K2317/55 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2317/92 , C07K2319/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
摘要翻译： 本发明提供用于治疗与EGFRvIII表达相关的疾病的组合物和方法。 本发明还涉及对EGFRvIII特异性的嵌合抗原受体（CAR），编码它的载体和包含抗-EGFRVIII CAR的重组T细胞。 本发明还包括施用表达CAR的遗传修饰的T细胞的方法，其包含抗EGFRvIII结合结构域。
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公开(公告)号：EP4406610A3
公开(公告)日：2024-10-30
申请号：EP24166976.1
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61K39/00 , A61K35/17 , A61K31/436 , A61P35/02
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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4.发明公开COMBINATION OF CHIMERIC ANTIGEN RECEPTOR THERAPY AND AMINO PYRIMIDINE DERIVATIVES 审中-公开嵌合抗原受体疗法与氨基嘧啶衍生物的组合
公开(公告)号：EP3280795A1
公开(公告)日：2018-02-14
申请号：EP16718786.3
申请日：2016-04-07
申请人： Novartis AG , The Trustees of The University of Pennsylvania , Byrd, John , Dubovsky, Jason , Johnson, Amy , June, Carl, H. , Muthusamy, Natarajan , Porter, David L. , Wasik, Mariusz
发明人： BYRD, John , DUBOVSKY, Jason , JOHNSON, Amy , JUNE, Carl, H. , MUTHUSAMY, Natarajan , PORTER, David, L. , WASIK, Mariusz , ANGST, Daniela , FRAIETTA, Joseph, A. , GESSIER, Francois , GILL, Saar , MAUS, Marcela , RUELLA, Marco , VULPETTI, Anna
IPC分类号： C12N5/0783 , A61K31/505 , A61K31/506 , A61K45/06
CPC分类号： A61K31/505 , A61K31/506 , A61K35/17 , A61K45/06 , A61K2035/124 , A61K2039/505 , A61K2039/545 , A61P35/00 , A61P35/02 , C07K16/2803 , C07K16/30 , C07K2317/24 , C07K2317/53 , C07K2317/56 , C07K2317/565 , C07K2317/622 , C07K2319/02 , C07K2319/03 , C12N5/0636 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a BTK inhibitor, e.g., an amino pyrimidine derivative described herein. The invention also provides kits and compositions described herein.
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5.发明公开TREATMENT OF CANCER USING ANTI-CD19 CHIMERIC ANTIGEN RECEPTOR 审中-公开TOR UNG ON ON BS TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR TOR
公开(公告)号：EP3129470A1
公开(公告)日：2017-02-15
申请号：EP15719043.0
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl, H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David, L. , RUELLA, Marco , SELLERS, William, Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： C12N5/0783 , A61K35/17 , A61K31/00 , A61P35/02
CPC分类号： A61K35/17 , A61K31/436 , A61K31/519 , A61K31/53 , A61K39/3955 , A61K39/39558 , A61K45/06 , A61K2039/505 , A61K2039/5156 , A61K2039/5158 , C07K14/7051 , C07K16/2803 , C07K2317/14 , C07K2317/24 , C07K2317/565 , C07K2317/622 , C07K2317/73 , C07K2319/03 , C12N5/0636 , C12N2501/599 , C12N2501/727 , C12N2510/00 , A61K2300/00
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
摘要翻译： 本发明提供了用于治疗与CD19表达相关的疾病的组合物和方法，例如通过如本文所述施用包含本文所述的CD19 CAR的重组T细胞与激酶抑制剂，例如本文所述的激酶抑制剂组合。 本发明还提供了本文所述的试剂盒和组合物。
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公开(公告)号：EP4406610A2
公开(公告)日：2024-07-31
申请号：EP24166976.1
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61P35/02
CPC分类号： C12N5/0636 , C12N2501/72720130101 , C07K16/2803 , A61K31/519 , A61K45/06 , A61K31/436 , A61K31/53 , C07K2317/62220130101 , C07K2319/0320130101 , C07K2317/7320130101 , A61P35/00 , A61P35/02 , A61P43/00 , A61K39/001112 , A61K2239/3820230501 , A61K39/4631 , A61K2239/2620230501 , A61K2239/4820230501 , A61K39/464412 , A61K2239/3120230501 , A61K39/4611 , A61K39/4636
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：EP4067382A1
公开(公告)日：2022-10-05
申请号：EP22159001.1
申请日：2014-03-15
IPC分类号： C07K16/28 , A61K35/14 , C07K14/725 , C07K14/705 , C07K16/30 , C12N5/0783 , A61P35/00
摘要： The disclosure provides compositions and methods for treating diseases associated with expression of CD19. The disclosure also relates to chimeric antigen receptor (CAR) specific to CD19, vectors encoding the same, and recombinant T cells comprising the CD19 CAR. The disclosure also includes methods of administering a genetically modified T cell expressing a CAR that comprises a CD 19 binding domain.
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公开(公告)号：EP3888674A1
公开(公告)日：2021-10-06
申请号：EP21160203.2
申请日：2015-04-07
发明人： BYRD, John , DUBOVSKY, Jason , FRAIETTA, Joseph , GILL, Saar , GLASS, David , JOHNSON, Amy , JUNE, Carl H. , KENDERIAN, Saad , MANNICK, Joan , MAUS, Marcela , MURPHY, Leon , MUTHUSAMY, Natarajan , PORTER, David L. , RUELLA, Marco , SELLERS, William Raj , WASIK, Mariusz , BROGDON, Jennifer
IPC分类号： A61K39/00 , A61K35/17 , A61K31/436 , A61P35/02
摘要： The invention provides compositions and methods for treating diseases associated with expression of CD19, e.g., by administering a recombinant T cell comprising the CD19 CAR as described herein, in combination with a kinase inhibitor, e.g., a kinase inhibitor described herein. The invention also provides kits and compositions described herein.
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公开(公告)号：EP3626741A1
公开(公告)日：2020-03-25
申请号：EP19196212.5
申请日：2014-02-20
申请人： The Trustees of The University of Pennsylvania , University of Pittsburgh - Of the Commonwealth System of Higher Education , Novartis AG
发明人： BROGDON, Jennifer , LOEW, Andreas , JOHNSON, Laura Alexandra , JUNE, Carl H. , MAUS, Marcela , SCHOLLER, John , OKADA, Hideho
摘要： The invention provides compositions and methods for treating diseases associated with expression of EGFRvIII. The invention also relates to chimeric antigen receptor (CAR) specific to EGFRvIII, vectors encoding the same, and recombinant T cells comprising the anti-EGFRvIII CAR. The invention also includes methods of administering a genetically modified T cell expressing a CAR that comprises an anti-EGFRvIII binding domain.
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公开(公告)号：EP2958943B1
公开(公告)日：2019-09-11
申请号：EP14713280.7
申请日：2014-02-20
申请人： The Trustees of The University of Pennsylvania , University of Pittsburgh - Of the Commonwealth System of Higher Education , Novartis AG
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