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    METHOD OF MANUFACTURING PREFILLED DRUG DELIVERY DEVICES
    1.
    发明公开
    METHOD OF MANUFACTURING PREFILLED DRUG DELIVERY DEVICES 审中-公开

    公开(公告)号：EP3368105A1

    公开(公告)日：2018-09-05

    申请号：EP16787471.8

    申请日：2016-10-27

    申请人： Novo Nordisk A/S

    发明人： ANDERSEN, Carsten Schau ,  RØRVIG, Simon ,  HANSEN, Steffen

    IPC分类号： A61M5/31

    CPC分类号： A61M5/31513 ,  A61M5/20 ,  A61M5/3146 ,  A61M5/31501 ,  A61M5/31515 ,  A61M5/31583 ,  A61M2207/00

    摘要： The present invention provides a method of manufacturing a prefilled drug delivery device comprising the steps of arranging a piston rod member (20, 22, 120, 122) and a piston rod guide (40, 140) in a housing (10, 110) such that the piston rod member extends through a guide structure (13, 113) fixed in the housing and is surrounded by and operatively coupled with the piston rod guide, whereby rotation of the piston rod guide in a first direction relative to the housing causes distal movement of the piston rod member relative to the guide structure, and vice versa, and rotation of the piston rod guide in a second direction relative to the housing causes proximal movement of the piston rod member relative to the guide structure, and vice versa, and the piston rod guide is in a first state being capable of bi-directional rota-tion with respect to the housing, bringing a displaceable wall (62, 162) of a variable volume drug reservoir (60, 160) into abutment with a distal end portion of the piston rod member, moving the variable volume drug reservoir proximally relative to the housing to a completely mounted position, and shifting the piston rod guide irreversibly to a second state in which rotation of the piston rod guide in the second direction relative to the housing is prevented.

    DRUG DELIVERY DEVICE WITH PISTON PROXIMITY SENSING
    2.
    发明公开
    DRUG DELIVERY DEVICE WITH PISTON PROXIMITY SENSING 审中-公开
    带活塞接近检测药物供应DEVICE

    公开(公告)号：EP2830680A1

    公开(公告)日：2015-02-04

    申请号：EP13713832.7

    申请日：2013-03-26

    申请人： Novo Nordisk A/S

    发明人： MUNK, Jens Aage ,  ANDERSEN, Carsten Schau ,  LARSEN, Bjørn Gullak ,  HOLM, Per Einar Pontus

    IPC分类号： A61M5/145 ,  A61M5/20 ,  H03K17/945

    CPC分类号： A61M5/172 ,  A61M5/1456 ,  A61M5/14566 ,  A61M5/20 ,  A61M2205/33 ,  A61M2205/3306

    摘要： Drug delivery device with electronically controlled and axially displaceable piston drive member (10) adapted to engage a loaded cartridge piston. The piston drive member is moveable between a proximal loading position in which a cartridge can be received and a distal loaded position in engagement with the piston. A proximity sensor (11,12) provides a varying output indicative of a varying distance between the piston drive member and the piston. A controller (30) coupled to the proximity sensor is configured to control movement of the piston drive member from the loading position to the loaded position and stop movement when the controller based on input from the proximity sensor system determines that the loaded position has just been reached. By this arrangement it is prevented that a drug-filled cartridge is pressurized during the loading and initializing procedure.

    TELESCOPIC DRIVE ARRANGEMENT FOR DRUG DELIVERY DEVICE
    3.
    发明公开
    TELESCOPIC DRIVE ARRANGEMENT FOR DRUG DELIVERY DEVICE 审中-公开
    TELESKOPARTIGE ANTRIEBSANORDNUNGFÜRWIRKSTOFFFREISETZUNGSVORRICHTUNG

    公开(公告)号：EP3137135A1

    公开(公告)日：2017-03-08

    申请号：EP15718913.5

    申请日：2015-04-29

    申请人： Novo Nordisk A/S

    发明人： LARSEN, Bjørn Gullak ,  ANDERSEN, Carsten Schau ,  HØHOLT, Jesper ,  HOUGAARD, Finn

    IPC分类号： A61M5/315 ,  F16H25/22

    CPC分类号： A61M5/31583 ,  A61M5/24 ,  A61M5/31501 ,  A61M5/31513 ,  A61M5/31546 ,  A61M39/10 ,  A61M2005/2481 ,  A61M2005/31518 ,  A61M2005/31588 ,  A61M2039/1022 ,  A61M2205/14 ,  A61M2205/581 ,  A61M2205/583 ,  A61M2205/8206 ,  F16H25/20 ,  F16H2025/2075

    摘要： Drug delivery device adapted to receive a cartridge, comprising a drive tube with an inner thread, a motor assembly comprising a drive shaft and being adapted to be received inside the drive tube, a drive member attached to the drive shaft and with an outer thread in engagement with the drive tube inner thread. The drive tube is arranged axially displaceable but non-rotational relative to the motor assembly, whereby rotation of the drive member results in axial, non-rotational displacement of the drive tube. To provide flexibility the drive shaft is connected to the drive member via a first flexible joint, and the motor assembly proximal portion is connected to a support structure via a second flexible joint.

    摘要翻译： 适于容纳药筒的药物输送装置，包括具有内螺纹的驱动管，包括驱动轴的马达组件，适于容纳在驱动管内;驱动构件，其附接到驱动轴并具有外螺纹 与驱动管内螺纹接合。 驱动管相对于马达组件轴向移动但不旋转，由此驱动构件的旋转导致驱动管的轴向非旋转位移。 为了提供灵活性，驱动轴通过第一柔性接头连接到驱动构件，并且马达组件近端部分经由第二柔性接头连接到支撑结构。

    DRUG DELIVERY DEVICE WITH VARIABLE DOSE SETTING MECHANISM
    5.
    发明公开
    DRUG DELIVERY DEVICE WITH VARIABLE DOSE SETTING MECHANISM 审中-公开
    WIRKSTOFFFREISETZUNGSVORRICHTUNG MIT VARIABLEM DOSIERUNGSMECHANISMUS

    公开(公告)号：EP2919835A1

    公开(公告)日：2015-09-23

    申请号：EP13798605.5

    申请日：2013-11-19

    申请人： Novo Nordisk A/S

    发明人： HØHOLT, Jesper ,  MONRAD, Michael ,  ANDERSEN, Carsten Schau ,  GRUBBE, Mikkel Schouenborg ,  PEDERSEN, Bennie Peder Smiszek

    IPC分类号： A61M5/24 ,  A61M5/31

    CPC分类号： A61M5/31551 ,  A61M5/24 ,  A61M5/31528 ,  A61M5/31553 ,  A61M2005/2407 ,  A61M2005/3126 ,  A61M2202/0007 ,  A61M2205/43 ,  A61M2205/50 ,  A61M2205/6036 ,  A61M2205/6045

    摘要： A drug delivery system (1) comprising first (35) and second reservoir units (30) with first and second identifiers (32), and a main unit (10) adapted to receive either of the first (35) and second reservoir units (30) in a mounted position. The main unit (10) comprises drug expelling means having dose setting means (11, 1, 14, 15, 19) comprising a rotational dose setting member allowing a user to set a desired dose size for the given drug, the dose size being set in fixed increments for a given state. The drug expelling means has a first state in which an increment corresponds to a first volume of drug, and a second state in which an increment corresponds to a second volume of drug, wherein the drug expelling means is set in the first state by means of the first identifier when a first reservoir unit is mounted, and the drug expelling means is set in the second state by means of the second identifier when a second reservoir unit is mounted.

    摘要翻译： 一种药物输送系统（1），包括具有第一和第二标识符（32）的第一储存器单元（35）和第二储存器单元（30），以及主单元（10），适于接纳第一储存单元（35）和第二储存单元 30）处于安装位置。 主单元（10）包括具有剂量设定装置（11,1,14,15,19）的药物排出装置，其包括旋转剂量设定构件，允许使用者设​​定给定药物的所需剂量大小，设定剂量大小 以给定状态的固定增量。 药物排出装置具有第一状态，其中增量对应于第一体积的药物，并且第二状态，其中增量对应于第二体积的药物，其中药物排出装置被设置在第一状态，借助于 当安装第一储存器单元时的第一标识符，并且当安装第二储存器单元时，药物排出装置借助于第二标识符被设置在第二状态。

    DRIVE MECHANISM FOR AN INJECTION DEVICE
    10.
    发明公开
    DRIVE MECHANISM FOR AN INJECTION DEVICE 审中-公开
    ANTRIEBSMECHANISMUSFÜREINE INJEKTIONSVORRICHTUNG

    公开(公告)号：EP3071263A1

    公开(公告)日：2016-09-28

    申请号：EP14798836.4

    申请日：2014-11-13

    申请人： Novo Nordisk A/S

    发明人： HIGSON, Lee ,  GHULAM, Imran ,  NØRGAARD, Jesper Bach ,  HANSEN, Ken ,  GJØDESEN, Claus Urup ,  ANDERSEN, Carsten Schau ,  LARSEN, Asger Meng

    IPC分类号： A61M5/315 ,  A61M5/20

    CPC分类号： A61M5/31586 ,  A61M5/20 ,  A61M5/31501 ,  A61M5/31513 ,  A61M5/31543 ,  A61M5/31583

    摘要： The invention relates to a drive mechanism for a medical injection device in which a piston rod (10) has a threaded outer surface and a not circular cross-section and engages a nut assembly (2, 102, 202) having either an internal thread (41, 141, 241) mating the outer thread (11) of the piston rod (10), or a shape mating the non-circular cross section of the piston rod (10). The nut assembly (2) comprises a first part (30, 130, 230) and a second part (40, 140, 240), which are connected by a hinge allowing the first part (30, 130, 230) and the second part (40, 140, 240) to tilt relatively to each other in a non-axial plane.

    摘要翻译： 本发明涉及一种用于医疗注射装置的驱动机构，其中活塞杆（10）具有螺纹外表面和非圆形横截面并且与具有内螺纹（2,102,202）的螺母组件 配合活塞杆（10）的外螺纹（11）或与活塞杆（10）的非圆形截面配合的形状。 螺母组件（2）包括第一部分（30,130,230）和第二部分（40,140,​​240），第二部分（40,41,240,240）通过铰链连接，允许第一部分（30,130,230）和第二部分 （40,140,​​240）在非轴向平面中相对于彼此倾斜。