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    LIPASES FOR PHARMACEUTICAL USE
    1.
    发明公开
    LIPASES FOR PHARMACEUTICAL USE 审中-公开
    LIPASEN ZUR PHARMAZEUTISCHEN VERWENDUNG

    公开(公告)号：EP1896577A2

    公开(公告)日：2008-03-12

    申请号：EP06742471.3

    申请日：2006-06-16

    申请人： Novozymes A/S ,  Solvay Pharmaceuticals GmbH

    发明人： SVENDSEN, Allan ,  BORCH, Kim ,  GREGORY, Peter, Colin

    IPC分类号： C12N9/20 ,  A61K38/54 ,  A61K38/46

    CPC分类号： C12N9/20

    摘要： The pharmaceutical use of lipases related to a variant of the Thermomyces lanuginosus (Humicola lanuginosa) lipase comprising amino acids 1-269 of SEQ ID NO: 1, optionally in combination with a protease and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The lipases of the invention have an improved efficacy in vivo, are stable against protease-degradation, and/or are stable in the presence of bile salts.

    摘要翻译： 与包含SEQ ID NO：1的氨基酸1-269的Thermomyces lanuginosus（Humicola lanuginosa）脂肪酶的变体相关的脂肪酶的药物用途，任选地与蛋白酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 本发明的脂肪酶在体内具有改善的功效，对蛋白酶降解是稳定的，和/或在胆汁盐存在下是稳定的。

    AMYLASES FOR PHARMACEUTICAL USE
    2.
    发明公开
    AMYLASES FOR PHARMACEUTICAL USE 审中-公开
    AMYLASEN ZUR PHARMAZEUTISCHEN VERWENDUNG

    公开(公告)号：EP1896057A2

    公开(公告)日：2008-03-12

    申请号：EP06742473.9

    申请日：2006-06-16

    申请人： Novozymes A/S ,  Solvay Pharmaceuticals GmbH

    发明人： GREGORY, Peter, Colin ,  SVENDSEN, Allan

    IPC分类号： A61K38/47 ,  C12N9/28 ,  A61K38/54

    CPC分类号： C12N9/2417

    摘要： The pharmaceutical use of amylases related to Bacillus alpha-amylases of SEQ ID NOs: 1-3, optionally in combination with a lipase and/or a protease. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II. The amylases of SEQ ID NOs: 1-3 are variants of amylases from Bacillus stearothermophilus, Bacillus licheniformis and Bacillus sp. The amylases of the invention have an improved efficacy in vivo, an improved pH-profile, a high specific activity, and/or an improved starch degradation profile.

    摘要翻译： 与SEQ ID NO：1-3的芽孢杆菌α-淀粉酶相关的淀粉酶的药物用途，任选地与脂肪酶和/或蛋白酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。 SEQ ID NO：1-3的淀粉酶是来自嗜热脂肪芽孢杆菌，地衣芽孢杆菌和芽孢杆菌属的淀粉酶的变体。 本发明的淀粉酶在体内具有改善的功效，改善的pH值，高比活性和/或改进的淀粉降解特征。

    PROTEASES FOR PHARMACEUTICAL USE
    3.
    发明公开
    PROTEASES FOR PHARMACEUTICAL USE 审中-公开
    PROTEASEN ZUR PHARMAZEUTISCHEN VERWENDUNG

    公开(公告)号：EP1896058A2

    公开(公告)日：2008-03-12

    申请号：EP06742472.1

    申请日：2006-06-16

    申请人： Novozymes A/S ,  Solvay Pharmaceuticals GmbH

    发明人： SVENDSEN, Allan ,  FUGLSANG, Claus Crone ,  GREGORY, Peter, Colin

    IPC分类号： A61K38/48 ,  C12N9/54 ,  A61K38/54

    CPC分类号： C12N9/54

    摘要： The pharmaceutical use of proteases related to amino acids 1-274 of SEQ ID NO: 2, the serine protease derived from Bacillus licheniformis, which is also designated subtilisin Carlsberg, optionally in combination with a lipase and/or an amylase. Examples of medical indications are: Treatment of digestive disorders, pancreatic exocrine insufficiency (PEI), pancreatitis, cystic fibrosis, diabetes type I, and/or diabetes type II.

    摘要翻译： 与SEQ ID NO：2的氨基酸1-274相关的蛋白酶的药物用途，衍生自地衣芽孢杆菌的丝氨酸蛋白酶，其也被称为枯草杆菌蛋白酶卡尔斯伯格，任选与脂肪酶和/或淀粉酶组合。 医学适应症的例子有：消化系统疾病，胰腺外分泌功能不全（PEI），胰腺炎，囊性纤维化，I型糖尿病和/或II型糖尿病的治疗。