公开(公告)号：EP3071214A4

公开(公告)日：2017-09-06

申请号：EP14864855

申请日：2014-11-19

申请人： OMNIACTIVE HEALTH TECH (CANADA) LTD

发明人： DESHPANDE JAYANT ,  GHANAM KHADIJA ,  EWART STEPHEN ,  JUTURU VIJAYA

IPC分类号： A61K36/37 ,  A61K31/352 ,  A61K31/575 ,  A61P3/04 ,  C07H7/04 ,  C07J71/00 ,  C12N9/04 ,  C12N9/16

CPC分类号： A61K36/37 ,  A23L33/10 ,  A23L33/105 ,  A61K31/122 ,  A61K31/192 ,  A61K31/7048

摘要： A Salacia composition described herein significantly reduces appetite, activates Hormone Sensitive Lipase, and manages a healthy lipid profile through inhibition of HMG-CoA Reductase enzyme. Salacia compositions described herein include of at least 12% of polyphenols, 2% of mangiferin and 1% of 25,26-oxidofriedelane-1,3-dione by weight of the composition in the form of extract. The composition is obtained by continuous solvent extraction, employing non-aqueous food grade solvents. Salacia compositions herein reduce appetite by about 18% of routine diet, when effective amounts are administered to a subject in need thereof. Effective management of a healthy lipid profile is thus possible with synergistic combination of reduction in energy intake, activation of Hormone Sensitive Lipase, and inhibition of HMG-CoA Reductase enzyme responsible for cholesterol metabolism.

摘要翻译： 本文所述的五层龙组合物显着降低食欲，激活激素敏感性脂肪酶，并通过抑制HMG-CoA还原酶来管理健康的脂质特征。 本文所述的沙拉西亚组合物包含按提取物形式的组合物的重量计至少12％的多酚，2％的芒果苷和1％的25,26-氧化十三烯-1,3-二酮。 该组合物通过使用非水性食品级溶剂的连续溶剂萃取而获得。 当将有效量给予有需要的受试者时，本文中的Salacia组合物减少约18％常规饮食的食欲。 因此，通过协同减少能量摄入，激活激素敏感性脂肪酶和抑制负责胆固醇代谢的HMG-CoA还原酶，可以有效管理健康的血脂谱。