公开(公告)号：EP2508204B1

公开(公告)日：2014-09-24

申请号：EP12005031.5

申请日：2003-06-25

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Nakade, Shinji ,  Suzuki, Hidehiro ,  Habashita, Hiromu

IPC分类号： A61K45/00 ,  A61K31/437 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D211/48 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/445 ,  C07D211/48

公开(公告)号：EP2508204A3

公开(公告)日：2012-12-12

申请号：EP12005031.5

申请日：2003-06-25

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Nakade, Shinji ,  Suzuki, Hidehiro ,  Habashita, Hiromu

IPC分类号： A61K45/00 ,  A61K31/437 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D211/48 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/445 ,  C07D211/48

摘要： A therapeutic and/or preventing agent for a disease due to vascular constriction or vasodilation comprising a EDG-5 modulator. Since EDG-5 modulator specifically binds EDG-5 and shows antagonistic or agonistic action, EDG-5 antagonist is useful for treating and/or preventing for a disease due to vascular constriction, for example, cerebrovascular spasmodic disorder after subarachnoid hemorrhage or stroke, cardiovasucular spasmodic disorder, hypertension, renal disease, cardiac infarction, cardiac angina, arrhythmia, facilitation of the portal blood pressure involved in liver cirrhosis, varicosity involved in liver cirrhosis and the like, or EDG-5 agonist is useful for treating and/or preventing for a disease due to vasodilation of blood vessels, for example, chronic headache (such as migraine, tension-type headache, mixed-type headache thereof, or migrainous neuralgia), haemorrhoid, congestive disorder and the like.

公开(公告)号：EP2508204A2

公开(公告)日：2012-10-10

申请号：EP12005031.5

申请日：2003-06-25

申请人： ONO PHARMACEUTICAL CO., LTD.

发明人： Nakade, Shinji ,  Suzuki, Hidehiro ,  Habashita, Hiromu

IPC分类号： A61K45/00 ,  A61K31/437 ,  A61K31/445 ,  A61P9/00 ,  A61P9/06 ,  A61P9/10 ,  A61P9/12 ,  A61P9/14 ,  A61P13/12 ,  A61P25/06 ,  A61P43/00 ,  C07D211/48 ,  C07D471/04

CPC分类号： C07D471/04 ,  A61K31/437 ,  A61K31/445 ,  C07D211/48

摘要： A therapeutic and/or preventing agent for a disease due to vascular constriction or vasodilation comprising a EDG-5 modulator. Since EDG-5 modulator specifically binds EDG-5 and shows antagonistic or agonistic action, EDG-5 antagonist is useful for treating and/or preventing for a disease due to vascular constriction, for example, cerebrovascular spasmodic disorder after subarachnoid hemorrhage or stroke, cardiovasucular spasmodic disorder, hypertension, renal disease, cardiac infarction, cardiac angina, arrhythmia, facilitation of the portal blood pressure involved in liver cirrhosis, varicosity involved in liver cirrhosis and the like, or EDG-5 agonist is useful for treating and/or preventing for a disease due to vasodilation of blood vessels, for example, chronic headache (such as migraine, tension-type headache, mixed-type headache thereof, or migrainous neuralgia), haemorrhoid, congestive disorder and the like.

摘要翻译： 用于疾病由于血管收缩或血管舒张的治疗和/或预防剂，其包含一个EDG-5调制器。 由于EDG-5调制器特异性结合EDG-5，并显示拮抗或激动作用，EDG-5拮抗剂是用于治疗和/或由于血管收缩预防的疾病，例如蛛网膜下腔出血或中风，cardiovasucular后，脑血管痉挛性疾病有用 痉挛性疾病，高血压，肾脏病，心肌梗塞，心绞痛，心律失常，肝硬化涉及的门血压的便利化，静脉曲张肝硬化参与和类似物，或EDG-5激动剂用于治疗和/或预防对是非常有用的 由于血管的血管舒张的疾病，例如，慢性头痛（：如偏头痛，紧张型头痛，混合型头痛，或其偏头痛性神经痛），痔疮，充血性障碍等。