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公开(公告)号：EP2046834B1
公开(公告)日：2012-10-10
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08 , C12N5/22 , C12N15/13
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP2046834A1
公开(公告)日：2009-04-15
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan, J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.
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公开(公告)号：EP2046834B9
公开(公告)日：2013-04-10
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08 , C12N5/22 , C12N15/13
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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