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公开(公告)号：EP2046834A1
公开(公告)日：2009-04-15
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan, J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to SDF-1 with high affinity. Nucleic acid molecules encoding SDF-1 antibodies, expression vectors, host cells and methods for expressing the SDF-1 antibodies are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the SDF-1 antibodies are also provided. Methods for detecting SDF-1, as well as methods for treating various B cell malignancies, including breast cancer, multiple myeloma and non-Hodgkin's lymphoma, and autoimmune disorders are disclosed.
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公开(公告)号：EP2046834B1
公开(公告)日：2012-10-10
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08 , C12N5/22 , C12N15/13
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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3.发明公开HUMAN MONOCLONAL ANTIBODIES TO PROGRAMMED DEATH 1(PD-1) AND METHODS FOR TREATING CANCER USING ANTI-PD-1 ANTIBODIES ALONE OR IN COMBINATION WITH OTHER IMMUNOTHERAPEUTICS 审中-公开人单克隆抗体程序性细胞死亡1（PD-1），和方法仅仅考虑用于癌症治疗的抗PD-1抗体或与其他免疫治疗学组合
公开(公告)号：EP1896582A1
公开(公告)日：2008-03-12
申请号：EP06746353.9
申请日：2006-05-02
发明人： KORMAN, Alan, J. , SRINIVASAN, Mohan , WANG, Changyu , SELBY, Mark, J. , CHEN, Bing , CARDARELLI, Josephine, M.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：EP2046834B9
公开(公告)日：2013-04-10
申请号：EP07792618.6
申请日：2007-08-10
发明人： POGUE, Sarah, L. , KORMAN, Alan J. , CARDARELLI, Josephine, M. , SRINIVASAN, Mohan , CHEN, Bingliang , BELL, Alasdair, F.
IPC分类号： C07K16/24 , A61K39/395 , A61P3/10 , A61P9/10 , A61P29/00 , A61P35/00 , A61P37/00 , A61P37/06 , A61P43/00 , C12P21/08 , C12N5/22 , C12N15/13
CPC分类号： C07K16/24 , A61K2039/505 , C07K2299/00 , C07K2317/21 , C07K2317/34 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/76 , C07K2317/92
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公开(公告)号：EP1711207B1
公开(公告)日：2012-11-28
申请号：EP04814015.6
申请日：2004-12-10
申请人： Medarex, Inc.
IPC分类号： C07K16/24 , A61K39/395
CPC分类号： C07K16/249 , A61K51/1021 , A61K2039/505 , C07K16/24 , C07K2317/21 , C07K2317/55 , C07K2317/56 , C07K2317/565 , C07K2317/74 , C07K2317/76
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公开(公告)号：EP1631590A2
公开(公告)日：2006-03-08
申请号：EP04750579.7
申请日：2004-04-23
申请人： MEDAREX, INC.
发明人： CARDARELLI, Josephine, M. , CHEN, Tseng-hui, Timothy , KING, David , BEBBINGTON, Christopher, R. , POGUE, Sarah, Lee , CARR, Francis J. , WILLIAMS, Stephen
IPC分类号： C07K16/00
CPC分类号： C07K16/2866 , A61K2039/505 , C07K2317/24 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/70 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： Humanized monoclonal antibodies which bind to IFNAR-1, and related antibody-based compositions and molecules, are disclosed. Also disclosed are pharmaceutical compositions comprising the humanized antibodies and therapeutic and diagnostic methods for using the humanized antibodies.
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公开(公告)号：EP1851250B1
公开(公告)日：2012-06-06
申请号：EP06735489.4
申请日：2006-02-17
申请人： Medarex, Inc.
CPC分类号： C07K16/3069 , A61K2039/505 , C07K2317/21
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PSMA with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecifÊc molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for treating cancer.
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公开(公告)号：EP1691837A2
公开(公告)日：2006-08-23
申请号：EP04813771.5
申请日：2004-12-10
申请人： MEDAREX, INC.
发明人： DESHPANDE, Shrikant , HUANG, Haichun , SRINIVASAN, Mohan , CARDARELLI, Josephine, M. , WANG, Changyu , PASSMORE, David , RANGAN, Vangipuram, S. , LANE, Thomas, E. , KEIRSTEAD, Hans, S. , LIU, Michael, T.
IPC分类号： A61K39/395 , C12N5/10 , C12N15/00 , C12N15/63 , C07H21/04
CPC分类号： C07K16/24 , A61K2039/505 , C07K14/522 , C07K2317/21 , C07K2317/33 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/76 , C07K2317/92
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to IP-10 with high affinity, inhibit the binding of IP- 10 to its receptor, inhibit IP-10-induced calcium flux and inhibit IP-10-induced cell migration. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting IP-10 activity using the antibodies of the invention, including methods for treating various inflammatory and autoimmune diseases.
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9.发明公开HUMAN MONOCLONAL ANTIBODIES TO FUCOSYL-GM1 AND METHODS FOR USING ANTI-FUCOSYL-GM1 有权人类单克隆抗体的岩藻糖基GM1 AND METHOD FOR抗岩藻糖GM1中的应用
公开(公告)号：EP1960434A2
公开(公告)日：2008-08-27
申请号：EP06840172.8
申请日：2006-12-08
申请人： MEDAREX, INC.
发明人： VISTICA, Cynthia, A. , HOLMES, Eric, H. , BRAMS, Peter , WITTE, Alison , CARDARELLI, Josephine, M.
IPC分类号： C07K16/30 , A61P35/00 , A61K39/395
CPC分类号： C07K16/3084 , A61K39/39558 , A61K45/06 , A61K2039/505 , C07K2317/21 , C07K2317/56 , C07K2317/565 , C07K2317/732 , C07K2317/734 , C07K2317/77
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human monoclonal antibodies that specifically bind to Fucosyl-GM1 with high affinity. Nucleic acid molecules encoding the antibodies of this disclosure, expression vectors, host cells and methods for expressing the antibodies of this disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of this disclosure are also provided. This disclosure also provides methods for detecting Fucosyl-GM1, as well as methods for treating various diseases, including cancer, using anti-Fucosyl-GM1 antibodies.
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公开(公告)号：EP1940470B1
公开(公告)日：2013-04-17
申请号：EP06825196.6
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： BOYD, Sharon, Elaine , CHEN, Liang , GANWAR, Sanjeev , GUERLAVAIS, Vincent , HORGAN, Kilian , SUFI, Bilal , CARDARELLI, Josephine, M. , PAN, Chin , HUANG, Haichun , KING, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
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