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1.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2439272A3
公开(公告)日：2013-07-31
申请号：EP11178188.6
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J. , Huang, Haichun
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：EP2418278A2
公开(公告)日：2012-02-15
申请号：EP11178187.8
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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3.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2418278A3
公开(公告)日：2012-07-04
申请号：EP11178187.8
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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4.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开针对程序性死亡1的人单克隆抗体（PD-1）以及单独或与其他免疫治疗剂组合使用抗PD-1抗体治疗癌症的方法
公开(公告)号：EP2439272A2
公开(公告)日：2012-04-11
申请号：EP11178188.6
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供了以高亲和力与PD-1特异性结合的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和表达本发明抗体的方法。 还提供了包含本发明抗体的免疫缀合物，双特异性分子和药物组合物。 本发明还提供了用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和传染病）的方法。 本发明进一步提供了使用组合免疫疗法（例如抗CTLA-4和抗PD-1抗体的组合）治疗过度增殖性疾病（例如癌症）的方法。 本发明还提供了改变与用这种抗体分别治疗有关的不良事件的方法。
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公开(公告)号：EP2439273B1
公开(公告)日：2019-02-27
申请号：EP11178191.0
申请日：2006-05-02
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6.发明公开Conjugates of duocarmycin and anti-CD70 or anti-PSMA antibodies 审中-公开Konjugate von Duocarmycin和Anti-CD70 oder Anti-PSMAAntikörpern
公开(公告)号：EP2354163A2
公开(公告)日：2011-08-10
申请号：EP11155501.7
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： Boyd, Sharon, Elaine , Chen, Liang , Ganwar, Sanjeev , Guerlavais, Vincent , Horgan, Kilian , Sufi, Bilal , Cardarelli, Josephine, M. , Pan, Chin , Huang, Haichun , King, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
摘要翻译： 本公开提供了抗体 - 药物偶联物，其是有效的细胞毒素，其中药物通过接头与抗体连接。 本公开还涉及含有抗体 - 药物共轭物的组合物以及使用它们的治疗方法。
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公开(公告)号：EP2354163A3
公开(公告)日：2013-04-24
申请号：EP11155501.7
申请日：2006-09-26
申请人： Medarex, Inc.
发明人： Boyd, Sharon, Elaine , Chen, Liang , Ganwar, Sanjeev , Guerlavais, Vincent , Horgan, Kilian , Sufi, Bilal , Cardarelli, Josephine, M. , Pan, Chin , Huang, Haichun , King, David, John
CPC分类号： C07K5/06052 , A61K38/00 , A61K47/6803 , A61K47/6805 , A61K47/6809 , A61K47/6869 , A61K47/6889 , B82Y30/00
摘要： The present disclosure provides antibody-drug conjugates that are potent cytotoxins, wherein the drug is linked to the antibody through a linker. The disclosure is also directed to compositions containing the antibody-drug conjugates, and to methods of treatment using them.
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