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公开(公告)号：EP2687531A1
公开(公告)日：2014-01-22
申请号：EP12761051.7
申请日：2012-01-05
IPC分类号： C07D471/14 , A61K31/4375 , A61K31/444 , A61K31/4545 , A61K31/496 , A61K45/00 , A61P11/00 , A61P13/02 , A61P13/08 , A61P17/00 , A61P19/02 , A61P29/00 , A61P35/00 , A61P43/00
CPC分类号： C07D471/14 , A61K9/0019 , A61K9/19 , A61K9/2054 , A61K31/435 , A61K31/437 , A61K47/26 , C07D471/04 , C07D471/12
摘要： An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect.
The present invention provides a compound represented by the general formula (I):
(wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and/or improving symptoms thereof, containing them as an active ingredient.-
2.发明公开NITROGEN-CONTAINING HETEROCYCLIC COMPOUND AND PHARMACEUTICAL APPLICATION THEREOF 有权药剂师联合会药剂师安东尼·戴文（VARBINDUNG AND PHARMAZEUCHSCHE ANWENDUNG DAVON）
公开(公告)号：EP1932840A1
公开(公告)日：2008-06-18
申请号：EP06811080.8
申请日：2006-10-02
IPC分类号： C07D401/04 , A61K31/4439 , A61K45/00 , A61P9/00 , A61P11/00 , A61P19/02 , A61P19/08 , A61P29/00 , A61P43/00 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
CPC分类号： A61K31/00 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
摘要： It is intended to provide a compound represented by the formula (I):
wherein all the symbols are as defined in the description;
which has a p38 MAP kinase inhibitory activity, a salt thereof, an N-oxide thereof, a solvate thereof, or a prodrug thereof. The compound of the invention is useful for preventing or treating a disease in which the abnormal production of a cytokine such as an inflammatory cytokine or a chemokine or overreaction to them is considered to be involved in the cause and aggravation of pathological conditions, in other words, an inflammatory disease, a respiratory disease, a cardiovascular disease, a central nervous system disease or the like, which is a cytokine-mediated disease.摘要翻译： 旨在提供由式（I）表示的化合物：其中所有符号如说明书中所定义; 其具有p38 MAP激酶抑制活性，其盐，其N-氧化物，其溶剂合物或其前药。 本发明化合物可用于预防或治疗其中细胞因子如炎性细胞因子或趋化因子的异常产生或对其过度反应被认为参与病理状况的原因和加重的疾病，换句话说 ，炎性疾病，呼吸系统疾病，心血管疾病，中枢神经系统疾病等，其是细胞因子介导的疾病。
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公开(公告)号：EP3290413B1
公开(公告)日：2019-11-13
申请号：EP17193874.9
申请日：2012-12-20
发明人： KONDO, Takashi , IMAGAWA, Akira , NAKATANI, Shingo , SUZUKI, Ryo , KOUYAMA, Sho , COURTNEY, Steve , YARNOLD, Chris , FLANAGAN, Stuart , BRACE, Gareth Neil , BARKER, John , ICHIHARA, Osamu , GADOULEAU, Elise , RICHARDSON, Anthony
IPC分类号： C07D401/14 , C07D403/14 , C07D471/04 , C07D487/04
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公开(公告)号：EP2592081B1
公开(公告)日：2017-03-08
申请号：EP11803561.7
申请日：2011-07-05
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/497 , A61K45/00 , A61P11/00 , A61P13/00 , A61P13/08 , A61P17/00 , A61P19/02 , A61P21/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D471/14 , A61K45/06 , A61K31/496
CPC分类号： A61K31/4375 , A61K31/437 , A61K31/496 , A61K45/00 , A61K45/06 , C07D471/04 , C07D471/14 , A61K2300/00
摘要： An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. The present invention provides a compound represented by the general formula (I): (wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and/or improving symptoms thereof, containing them as an active ingredient.
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5.发明授权
公开(公告)号：EP1932840B1
公开(公告)日：2014-04-09
申请号：EP06811080.8
申请日：2006-10-02
IPC分类号： C07D401/04 , A61K31/4439 , A61K45/00 , A61P9/00 , A61P11/00 , A61P19/02 , A61P19/08 , A61P29/00 , A61P43/00 , C07D405/14 , C07D413/04
CPC分类号： A61K31/00 , A61K31/4439 , A61K45/06 , C07D401/04 , C07D405/14 , C07D413/04 , C07D413/14 , C07D417/14
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公开(公告)号：EP3002285B1
公开(公告)日：2018-08-29
申请号：EP15190651.8
申请日：2011-07-05
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/497 , A61K45/00 , A61P11/00 , A61P13/00 , A61P13/08 , A61P17/00 , A61P19/02 , A61P21/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D471/14 , A61K45/06 , A61K31/496 , A61K31/444
CPC分类号： A61K31/437 , A61K31/4375 , A61K31/496 , A61K45/00 , A61K45/06 , C07D471/04 , C07D471/14 , A61K2300/00
摘要： An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. The present invention provides a compound represented by the general formula (I): (wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and/or improving symptoms thereof, containing them as an active ingredient.
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公开(公告)号：EP2687531B1
公开(公告)日：2016-07-13
申请号：EP12761051.7
申请日：2012-01-05
IPC分类号： C07D471/14 , A61K47/26 , A61K9/20 , A61K9/19 , A61K9/00
CPC分类号： C07D471/14 , A61K9/0019 , A61K9/19 , A61K9/2054 , A61K31/435 , A61K31/437 , A61K47/26 , C07D471/04 , C07D471/12
摘要： An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect. The present invention provides a compound represented by the general formula (I): (wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and/or improving symptoms thereof, containing them as an active ingredient.
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公开(公告)号：EP2592081A1
公开(公告)日：2013-05-15
申请号：EP11803561.7
申请日：2011-07-05
IPC分类号： C07D471/04 , A61K31/437 , A61K31/4375 , A61K31/4545 , A61K31/497 , A61K45/00 , A61P11/00 , A61P13/00 , A61P13/08 , A61P17/00 , A61P19/02 , A61P21/00 , A61P29/00 , A61P35/00 , A61P43/00 , C07D471/14
CPC分类号： A61K31/4375 , A61K31/437 , A61K31/496 , A61K45/00 , A61K45/06 , C07D471/04 , C07D471/14 , A61K2300/00
摘要： An object of the present invention is to provide a drug having the inhibitory activity on ENPP2 which is a different target from that of the existing drug, as a medicament useful in a urinary excretion disorder patient for whom the existing drug has the insufficient effect.
The present invention provides a compound represented by the general formula (I):
(wherein definition of each group is as defined in the description) having the ENPP2 inhibitory activity, a salt thereof or a solvate thereof or a prodrug thereof, and an agent for preventing or treating urinary excretion disorder and/or improving symptoms thereof, containing them as an active ingredient.-
公开(公告)号：EP3290413A1
公开(公告)日：2018-03-07
申请号：EP17193874.9
申请日：2012-12-20
发明人： KONDO, Takashi , IMAGAWA, Akira , NAKATANI, Shingo , SUZUKI, Ryo , KOUYAMA, Sho , COURTNEY, Steve , YARNOLD, Chris , FLANAGAN, Stuart , BRACE, Gareth Neil , BARKER, John , ICHIHARA, Osamu , GADOULEAU, Elise , RICHARDSON, Anthony
IPC分类号： C07D401/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P9/00
摘要： The present invention provides compounds of the general formula (I), their salts and N-oxides, and solvates and prodrugs thereof (wherein the characters are as defined in the description). The compounds of the general formula (I) are inhibitors of Factor XIa, so that they are useful in the prevention of and/or therapy for thromboembolic diseases.
摘要翻译： 本发明提供了通式（I）的化合物，它们的盐和N-氧化物，以及它们的溶剂化物和前药（其中特征如说明书中所定义）。 通式（I）的化合物是因子XIa的抑制剂，因此它们可用于预防和/或治疗血栓栓塞性疾病。
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公开(公告)号：EP2794597B1
公开(公告)日：2017-11-15
申请号：EP12813423.6
申请日：2012-12-20
发明人： COURTNEY, Steve , YARNOLD, Chris , FLANAGAN, Stuart , BRACE, Gareth , BARKER. John , ICHIHARA, Osamu , GADOULEAU, Elise , RICHARDSON, Anthony , KONDO, Takashi , IMAGAWA, Akira , NAKATANI, Shingo , SUZUKI, Ryo , KOUYAMA, Sho
IPC分类号： C07D401/14 , C07D471/04 , C07D487/04 , A61K31/437 , A61K31/519 , A61P9/00
CPC分类号： C07D487/04 , C07D401/14 , C07D403/14 , C07D471/04
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