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1.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2439272A3
公开(公告)日：2013-07-31
申请号：EP11178188.6
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J. , Huang, Haichun
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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2.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2439273A2
公开(公告)日：2012-04-11
申请号：EP11178191.0
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark J. , Chen, Bing , Cardarelli, Josephine M. , Korman, Alan J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/464 , Y02A50/466 , Y02A50/467 , Y02A50/469 , Y02A50/478 , Y02A50/487 , Y02A50/489
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供了分离的单克隆抗体，特别是人单克隆抗体，并特异性结合PD-1以高亲和力。 编码本发明的抗体的核酸分子，表达载体，宿主细胞和表达本发明的抗体的方法因此提供。 因此免疫缀合物，双特异性分子和药物组合物包含本发明的抗体提供的。 因此，本发明提供了用于治疗各种疾病，包括癌症和感染性疾病，使用抗PD-1抗体用于检测PD-1的方法，以及方法。 本发明进一步提供了使用免疫疗法组合,:方法如抗CTLA-4和抗PD-1抗体的组合，以治疗过度增殖性疾病，：如癌症。 因此本发明提供用于改变与治疗相关的独立与测试的抗体的不良事件的方法。
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3.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 有权为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2161336A1
公开(公告)日：2010-03-10
申请号：EP09013687.0
申请日：2006-05-02
发明人： Korman, Alan, J. , Srinivasan, Mohan , Wang, Changyu , Selby, Mark. J. , Chen, Bing , Cardarelli, Josephine M.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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4.发明授权Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 有权针对程序性死亡1的人单克隆抗体（PD-1）以及单独或与其他免疫治疗剂组合使用抗PD-1抗体治疗癌症的方法
公开(公告)号：EP2161336B1
公开(公告)日：2013-07-31
申请号：EP09013687.0
申请日：2006-05-02
发明人： Korman, Alan, J. , Srinivasan, Mohan , Wang, Changyu , Selby, Mark. J. , Chen, Bing , Cardarelli, Josephine M. , Huang, Haichun
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：EP2439273A3
公开(公告)日：2012-10-03
申请号：EP11178191.0
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark J. , Chen, Bing , Cardarelli, Josephine M. , Korman, Alan J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , Y02A50/386 , Y02A50/403 , Y02A50/407 , Y02A50/41 , Y02A50/412 , Y02A50/414 , Y02A50/464 , Y02A50/466 , Y02A50/467 , Y02A50/469 , Y02A50/478 , Y02A50/487 , Y02A50/489
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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6.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2418278A3
公开(公告)日：2012-07-04
申请号：EP11178187.8
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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7.发明公开Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 审中-公开针对程序性死亡1的人单克隆抗体（PD-1）以及单独或与其他免疫治疗剂组合使用抗PD-1抗体治疗癌症的方法
公开(公告)号：EP2439272A2
公开(公告)日：2012-04-11
申请号：EP11178188.6
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
摘要翻译： 本发明提供了以高亲和力与PD-1特异性结合的分离的单克隆抗体，特别是人单克隆抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和表达本发明抗体的方法。 还提供了包含本发明抗体的免疫缀合物，双特异性分子和药物组合物。 本发明还提供了用于检测PD-1的方法，以及使用抗PD-1抗体治疗各种疾病（包括癌症和传染病）的方法。 本发明进一步提供了使用组合免疫疗法（例如抗CTLA-4和抗PD-1抗体的组合）治疗过度增殖性疾病（例如癌症）的方法。 本发明还提供了改变与用这种抗体分别治疗有关的不良事件的方法。
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公开(公告)号：EP2418278A2
公开(公告)日：2012-02-15
申请号：EP11178187.8
申请日：2006-05-02
发明人： Srinivasan, Mohan , Wang, Changyu , Selby, Mark, J. , Chen, Bing , Cardarelli, Josephine, M. , Korman, Alan, J.
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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9.发明授权Human monoclonal antibodies to programmed death 1(PD-1) and methods for treating cancer using anti-PD-1 antibodies alone or in combination with other immunotherapeutics 有权为程序性死亡-1（PD-1）的人单克隆抗体，并用单独PD-1抗体或与其他免疫治疗剂组合治疗癌症的方法
公开(公告)号：EP2161336B2
公开(公告)日：2017-03-29
申请号：EP09013687.0
申请日：2006-05-02
发明人： Korman, Alan, J. , Srinivasan, Mohan , Wang, Changyu , Selby, Mark. J. , Chen, Bing , Cardarelli, Josephine M. , Huang, Haichun
CPC分类号： A61K39/39558 , A61K39/00 , A61K39/3955 , A61K47/6849 , A61K51/10 , A61K2039/505 , A61K2039/507 , C07K16/18 , C07K16/28 , C07K16/2803 , C07K16/2818 , C07K16/468 , C07K2317/21 , C07K2317/24 , C07K2317/33 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/73 , C07K2317/732 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94
摘要： The present invention provides isolated monoclonal antibodies, particularly human monoclonal antibodies, that specifically bind to PD-1 with high affinity. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for detecting PD-1, as well as methods for treating various diseases, including cancer and infectious diseases, using anti-PD-1 antibodies. The present invention further provides methods for using a combination immunotherapy, such as the combination of anti-CTLA-4 and anti-PD-1 antibodies, to treat hyperproliferative disease, such as cancer. The invention also provides methods for altering adverse events related to treatment with such antibodies individually.
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公开(公告)号：EP2439273B1
公开(公告)日：2019-02-27
申请号：EP11178191.0
申请日：2006-05-02
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