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1.发明公开
公开(公告)号：EP3130346A1
公开(公告)日：2017-02-15
申请号：EP16187710.5
申请日：2010-07-01
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
CPC分类号： C07K14/505 , C07K14/59 , C07K14/745 , C07K2319/31
摘要： A polypeptide consisting of a coagulation factor and one to five human chorionic gonadotropin carboxy terminal peptides (CTPs) attached to the carboxy terminus of said coagulation factor, wherein said coagulation factor is Factor VII or Factor VIIa, and wherein the sequence of said CTPs comprises the first 10 amino acids of SEQ ID NO: 4 (i.e., the amino acid sequence SSSSKAPPPS), and optionally, a signal peptide attached to the amino terminus of said coagulation factor. Pharmaceutical compositions comprising the polypeptides and medical uses thereof are also disclosed.
摘要翻译： 一种由凝血因子和1至5个连接到所述凝血因子的羧基末端的人绒毛膜促性腺激素羧基末端肽（CTP）组成的多肽，其中所述凝血因子是因子VII或因子VIIa，并且其中所述CTP的序列包括 SEQ ID NO：4的前10个氨基酸（即，氨基酸序列SSSSKAPPPS），以及任选的附着于所述凝血因子的氨基末端的信号肽。 还公开了包含多肽的药物组合物及其医疗用途。
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公开(公告)号：EP2822576A1
公开(公告)日：2015-01-14
申请号：EP13749077.7
申请日：2013-02-05
申请人： OPKO Biologics Ltd
发明人： FIMA, Udi Eyal , HART, Gili
IPC分类号： A61K38/36 , A61K38/24 , C07K14/475 , A61P7/04
CPC分类号： C07K14/59 , A61K38/24 , A61K38/4846 , C07K14/475 , C07K2319/31
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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公开(公告)号：EP3988113A1
公开(公告)日：2022-04-27
申请号：EP21188483.8
申请日：2016-06-19
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
摘要： A method for preparing a pharmaceutical formulation, the method comprising providing a Factor VII coagulation factor having three chorionic gonadotropin carboxy terminal peptides (CTPs) attached to its carboxy terminus, and mixing the CTP-modified Factor VII with a buffer and a tonicity agent; a syringe or an injectable pen device filled with the pharmaceutical formulation; and uses thereof.
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公开(公告)号：EP3791890A1
公开(公告)日：2021-03-17
申请号：EP20204439.2
申请日：2013-02-05
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
IPC分类号： A61K38/36 , A61K38/24 , C07K14/475 , A61P7/04 , C07K14/755
摘要： A chorionic gonadotropin carboxy terminal peptide (CTP)-modified Factor IX, Factor VII or Factor VIIa coagulation factor having three CTPs attached to the carboxy terminus of said coagulation factor for use in increasing patient compliance in coagulation factor therapy in a human subject or for use in treating hemophilia A in a human subject.
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公开(公告)号：EP3310347A2
公开(公告)日：2018-04-25
申请号：EP16811146.6
申请日：2016-06-19
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
CPC分类号： A61K38/4846 , A61K9/0019 , A61K38/00 , A61P7/04 , C07K2319/31 , C12N9/6437 , C12N9/644 , C12Y304/21021 , C12Y304/21022
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotropin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions and pharmaceutical formulations comprising the polypeptides and polynucleotides of the disclosure and methods of using and producing same are also disclosed.
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公开(公告)号：EP3326642B1
公开(公告)日：2020-11-25
申请号：EP18150731.0
申请日：2013-02-05
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
IPC分类号： A61K38/36 , A61K38/24 , C07K14/475 , A61P7/04 , C07K14/755
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公开(公告)号：EP3326642A1
公开(公告)日：2018-05-30
申请号：EP18150731.0
申请日：2013-02-05
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
IPC分类号： A61K38/36 , A61K38/24 , C07K14/475 , A61P7/04 , C07K14/755
CPC分类号： C07K14/59 , A61K38/24 , A61K38/4846 , C07K14/475 , C07K2319/31
摘要： A chorionic gonadotropin carboxy terminal peptide (CTP)-modified Factor IX, Factor VII or Factor VIIa coagulation factor having three CTPs attached to the carboxy terminus of said coagulation factor for use in reducing excessive bleeding or bruising or for use in maintaining hemostasis during surgery or during surgical interventions in a subject.
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公开(公告)号：EP2822576B1
公开(公告)日：2018-01-10
申请号：EP13749077.7
申请日：2013-02-05
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
IPC分类号： A61K38/36 , A61K38/24 , C07K14/475 , A61P7/04 , C07K14/755
CPC分类号： C07K14/59 , A61K38/24 , A61K38/4846 , C07K14/475 , C07K2319/31
摘要： Polypeptides comprising at least one carboxy-terminal peptide (CTP) of chorionic gonadotrophin attached to the carboxy terminus but not to the amino terminus of a coagulation factor and polynucleotides encoding the same are disclosed. Pharmaceutical compositions comprising the polypeptides and polynucleotides of the invention and methods of using and producing same are also disclosed.
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公开(公告)号：EP2451473B1
公开(公告)日：2016-10-19
申请号：EP10796803.4
申请日：2010-07-01
申请人： OPKO Biologics Ltd.
发明人： FIMA, Udi Eyal , HART, Gili
CPC分类号： C07K14/505 , C07K14/59 , C07K14/745 , C07K2319/31
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