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公开(公告)号：EP1493744B1
公开(公告)日：2009-11-25
申请号：EP04018348.5
申请日：1998-07-10
IPC分类号： C07D451/02 , C07D311/00 , C07C255/00 , C07C69/74 , C07C233/00 , C07C205/00 , C07C49/115 , C07C49/105 , C07C41/00 , C07C33/34 , C07D493/08 , C07F7/22 , A61K31/46 , A61K31/35 , A61P25/30
CPC分类号： C07D451/02 , A61K31/18 , A61K31/198 , A61K31/405 , A61K38/00 , A61K51/0448 , A61K2123/00 , C07C69/753 , C07C2602/44 , C07D451/06 , C07D471/08 , C07D493/08
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2.发明公开Tropane analogs and methods for inhibition of monoamine transport 失效Tropananloga und Methoden zur Hemmung des Transports von Monoaminen
公开(公告)号：EP1493744A1
公开(公告)日：2005-01-05
申请号：EP04018348.5
申请日：1998-07-10
IPC分类号： C07D451/02 , C07D311/00 , C07C255/00 , C07C69/74 , C07C233/00 , C07C205/00 , C07C49/115 , C07C49/105 , C07C41/00 , C07C33/34 , C07D493/08 , C07F7/22 , A61K31/46 , A61K31/35 , A61P25/30
CPC分类号： C07D451/02 , A61K31/18 , A61K31/198 , A61K31/405 , A61K38/00 , A61K51/0448 , A61K2123/00 , C07C69/753 , C07C2602/44 , C07D451/06 , C07D471/08 , C07D493/08
摘要： New tropane analogs that bind to monoamine transporters are described, particularly, 8-thio and 8-oxy tropanes, and especially those having 6- or 7-substituents. The compounds of the present invention can be racemic, pure R-enantiomers, or pure S-enantiomers. Certain preferred compounds of the present invention have a high selectivity for the DAT versus the SERT. Also described are pharmaceutical therapeutic compositions comprising the compounds formulated in a pharmaceutically acceptable carrier and a method for inhibiting 5-hydroxytryptamine reuptake of a monoamine transporter by contacting the monoamine transporter with a 5-hydroxytryptamine reuptake inhibiting amount of a compound of the present invention. Preferred monoamine transporters for the practice of the present invention include the dopamine transporter, the serotonin transporter and the norepinephrine transporter.
摘要翻译： 本发明涉及结合SERT以治疗神经精神障碍的非胺托烷类似物的治疗用途。
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