公开(公告)号：EP3998333A1

公开(公告)日：2022-05-18

申请号：EP20836408.3

申请日：2020-07-10

Applicant: Osaka University

Inventor： KINOOKA, Masahiro ,  KIM, Meehae

IPC: C12N5/071 ,  C12N5/10

Abstract: Provided is a method that is able to simply promote cell proliferation.
An aspect relates to a method for promoting proliferation of cells. The method includes adding a precursor of AGEs to a culture medium containing a cell aggregate, and culturing the cell aggregate in the culture medium to which the precursor of AGEs has been added

公开(公告)号：EP4477744A1

公开(公告)日：2024-12-18

申请号：EP23749881.1

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： KINOOKA, Masahiro ,  KIM, Meehae ,  FUJINAGA, Yukako

IPC: C12N5/071 ,  C07K14/33

Abstract: A method for producing a retinal pigment epithelial (RPE) cell, including promoting differentiation induction from a pluripotent stem cell into an RPE cell by culturing the pluripotent stem cell in a medium containing an E-cadherin inhibitor is provided by the present invention.

公开(公告)号：EP4477743A1

公开(公告)日：2024-12-18

申请号：EP23749882.9

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： KINOOKA, Masahiro ,  KIM, Meehae ,  FUJINAGA, Yukako

IPC: C12N5/02 ,  C12N5/0735 ,  C12N5/10

Abstract: The present invention provides an agent for directional control of differentiation induction of a pluripotent stem cell, comprising an E-cadherin inhibitor.