公开(公告)号：EP2929893A1

公开(公告)日：2015-10-14

申请号：EP13860873.2

申请日：2013-11-15

Applicant: Daiichi Sankyo Company, Limited ,  Osaka University

Inventor： FUJINAGA, Yukako ,  MATSUMURA, Takuhiro ,  YUTANI, Masahiro ,  JONAI, Nao

IPC: A61K39/39 ,  A61K39/02 ,  A61K39/12 ,  A61P31/00 ,  C07K14/33 ,  C07K19/00

CPC classification number: A61K39/39 ,  A61K39/00 ,  A61K39/02 ,  A61K39/12 ,  A61K39/145 ,  A61K2039/5252 ,  A61K2039/541 ,  A61K2039/543 ,  A61K2039/55516 ,  A61K2039/55544 ,  A61K2039/575 ,  C07K14/33 ,  C07K14/77 ,  C07K2319/42 ,  C12N7/00 ,  C12N2760/16134 ,  Y02A50/386 ,  Y02A50/39 ,  Y02A50/466 ,  Y02A50/472

Abstract: An object of the present invention is to provide an adjuvant for a mucosal vaccine with high safety that induces a sufficient immune response on the mucosa. According to the present invention, an adjuvant for a mucosal vaccine comprising a protein complex composed of hemagglutinin (HA) subcomponents HA1, HA2, and HA3 of botulinum toxin is provided.

Abstract translation: 本发明的目的是提供一种具有高安全性的粘膜疫苗佐剂，其在粘膜上诱导足够的免疫应答。 根据本发明，提供了一种包含由肉毒杆菌毒素的血凝素（HA），亚组分HA1，HA2和HA3组成的蛋白质复合物的粘膜疫苗佐剂。

公开(公告)号：EP4477744A1

公开(公告)日：2024-12-18

申请号：EP23749881.1

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： KINOOKA, Masahiro ,  KIM, Meehae ,  FUJINAGA, Yukako

IPC: C12N5/071 ,  C07K14/33

Abstract: A method for producing a retinal pigment epithelial (RPE) cell, including promoting differentiation induction from a pluripotent stem cell into an RPE cell by culturing the pluripotent stem cell in a medium containing an E-cadherin inhibitor is provided by the present invention.

公开(公告)号：EP4477743A1

公开(公告)日：2024-12-18

申请号：EP23749882.9

申请日：2023-02-06

Applicant: OSAKA UNIVERSITY

Inventor： KINOOKA, Masahiro ,  KIM, Meehae ,  FUJINAGA, Yukako

IPC: C12N5/02 ,  C12N5/0735 ,  C12N5/10

Abstract: The present invention provides an agent for directional control of differentiation induction of a pluripotent stem cell, comprising an E-cadherin inhibitor.

公开(公告)号：EP3715378A1

公开(公告)日：2020-09-30

申请号：EP18880123.7

申请日：2018-11-22

Applicant: National University Corporation Kanazawa University ,  Osaka University

Inventor： FUJINAGA, Yukako ,  AMATSU, Sho ,  KINOOKA, Masahiro

IPC: C07K19/00 ,  C07K14/33 ,  C12N5/071 ,  C12N15/31 ,  C12N15/62 ,  C12P21/02

Abstract: The present invention provides a miniaturized hemagglutinin complex protein having function inhibitory activity against E-cadherin, wherein
(a) all or a part of at least HA1 subcomponent, and/or a part of HA3 subcomponent are/is deleted,
(b) regions in HA2 and HA3 subcomponents that contribute to binding with E-cadherin are present, and
(c) the HA3 subcomponent is derived from Clostridium botulinum type A or type B, and an E-cadherin function inhibitor containing the hemagglutinin complex protein.