公开(公告)号：EP4353241A1

公开(公告)日：2024-04-17

申请号：EP22820089.5

申请日：2022-05-31

Applicant: OSAKA UNIVERSITY

Inventor： SHIMADA, Shoichi ,  KOYAMA, Yoshihisa ,  KONDO, Makoto ,  USUI, Noriyoshi ,  KOBAYASHI, Hikaru ,  KOBAYASHI, Yuki

IPC: A61K33/00 ,  A61P1/16 ,  A61P1/18 ,  A61P19/02 ,  A61P21/00 ,  A61P25/02 ,  A61P39/06

CPC classification number: A61P1/18 ,  A61P19/02 ,  A61P25/02 ,  A61K33/00 ,  A61P39/06 ,  A61P21/00 ,  A61P1/16

Abstract: [Object] An object is to provide a pharmaceutical or the like that can prevent or treat non-alcoholic fatty liver disease, pain associated with inactivity, or acute pancreatitis.
[Solving Means] When silicon small particles are orally administered or placed on a skin or a mucous membrane, non-alcoholic fatty liver disease, pain associated with inactivity, and acute pancreatitis can be prevented or treated. The silicon small particles are particles each of which generates hydrogen when brought into contact with an aqueous solution having a pH of 7 or more. Provided is a preventive or therapeutic agent, pharmaceutical composition, medical device, food, or beverage comprising the silicon small particles for non-alcoholic fatty liver disease, pain associated with inactivity, or acute pancreatitis. The silicon small particles are suitably silicon fine particles and/or aggregates of the silicon fine particles.

公开(公告)号：EP4495059A3

公开(公告)日：2025-03-26

申请号：EP24218136.0

申请日：2018-07-04

Applicant: OSAKA UNIVERSITY

Inventor： KOBAYASHI, Hikaru ,  KOBAYASHI, Yuki ,  IMAMURA, Ryoichi ,  NONOMURA, Norio

IPC: A61K33/00 ,  A61K9/56 ,  A61K47/04 ,  A61P9/10 ,  A61P13/12 ,  A61P39/06 ,  C01B3/08 ,  C01B33/02

Abstract: One drug (solid preparation) 100 of the present invention is a drug for a disease of kidney that contains a silicon fine particle, an aggregate of the silicon fine particles, or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of the kidney disease.

公开(公告)号：EP4495059A2

公开(公告)日：2025-01-22

申请号：EP24218136.0

申请日：2018-07-04

Applicant: OSAKA UNIVERSITY

Inventor： KOBAYASHI, Hikaru ,  KOBAYASHI, Yuki ,  IMAMURA, Ryoichi ,  NONOMURA, Norio

IPC: C01B3/06

Abstract: One drug (solid preparation) 100 of the present invention is a drug for a disease of kidney that contains a silicon fine particle, an aggregate of the silicon fine particles, or a crystal grain of silicon having a hydrogen-generating ability. Hydrogen generated from the silicon fine particle in the drug can contribute to the prevention and/or treatment of the kidney disease.