公开(公告)号：EP4368629A1

公开(公告)日：2024-05-15

申请号：EP22837707.3

申请日：2022-07-06

Applicant: OSAKA UNIVERSITY

Inventor： TAKAHASHI, Yusuke ,  WATANABE, Masakatsu ,  OKAMOTO, Motoki ,  HAYASHI, Mikako ,  KANIE, Kei ,  KATO, Ryuji ,  NARITA, Yuji ,  OGATA, Aika

IPC: C07K7/06 ,  A61K6/80 ,  A61K38/10 ,  A61P1/02 ,  C07K7/08

CPC classification number: A61K38/10 ,  C07K7/08 ,  C07K7/06 ,  A61K6/80 ,  A61P1/02

Abstract: The present invention addresses the problem of providing a peptide or a composition which can promote the healing of a wound at a dentin-pulp complex.
The problem can be solved by a peptide that comprises an amino acid sequence comprising Lys-Leu-Leu-Glu-Thr-Glu-Cys-Pro-Gln (SEQ ID NO: 28), an amino acid sequence comprising Asn-Thr-Asp-Gly-Ala-Val-Asn-Phe-Gln (SEQ ID NO: 32), an amino acid sequence comprising Glu-Leu-Val-Arg-Lys-Asp-Leu-Gln-Asn (SEQ ID NO: 47), an amino acid sequence comprising Asn-Ala-Asp-Lys-Gln-Leu-Ser-Phe-Glu (SEQ ID NO: 51), an amino acid sequence having such a structure that 1 to 3 amino acid residues in the amino acid sequence represented by SEQ ID NO: 28, SEQ ID NO: 32, SEQ ID NO: 47 or SEQ ID NO: 51 are substituted or deleted, or an amino acid sequence having such a structure that 1 to 3 amino acid residues are inserted into the amino acid sequence represented by SEQ ID NO: 28, SEQ ID NO: 32, SEQ ID NO: 47 or SEQ ID NO: 51, the peptide having a length of 9 to 15 amino acid residues.