公开(公告)号：EP4368629A1

公开(公告)日：2024-05-15

申请号：EP22837707.3

申请日：2022-07-06

Applicant: OSAKA UNIVERSITY

Inventor： TAKAHASHI, Yusuke ,  WATANABE, Masakatsu ,  OKAMOTO, Motoki ,  HAYASHI, Mikako ,  KANIE, Kei ,  KATO, Ryuji ,  NARITA, Yuji ,  OGATA, Aika

IPC: C07K7/06 ,  A61K6/80 ,  A61K38/10 ,  A61P1/02 ,  C07K7/08

CPC classification number: A61K38/10 ,  C07K7/08 ,  C07K7/06 ,  A61K6/80 ,  A61P1/02

Abstract: The present invention addresses the problem of providing a peptide or a composition which can promote the healing of a wound at a dentin-pulp complex.
The problem can be solved by a peptide that comprises an amino acid sequence comprising Lys-Leu-Leu-Glu-Thr-Glu-Cys-Pro-Gln (SEQ ID NO: 28), an amino acid sequence comprising Asn-Thr-Asp-Gly-Ala-Val-Asn-Phe-Gln (SEQ ID NO: 32), an amino acid sequence comprising Glu-Leu-Val-Arg-Lys-Asp-Leu-Gln-Asn (SEQ ID NO: 47), an amino acid sequence comprising Asn-Ala-Asp-Lys-Gln-Leu-Ser-Phe-Glu (SEQ ID NO: 51), an amino acid sequence having such a structure that 1 to 3 amino acid residues in the amino acid sequence represented by SEQ ID NO: 28, SEQ ID NO: 32, SEQ ID NO: 47 or SEQ ID NO: 51 are substituted or deleted, or an amino acid sequence having such a structure that 1 to 3 amino acid residues are inserted into the amino acid sequence represented by SEQ ID NO: 28, SEQ ID NO: 32, SEQ ID NO: 47 or SEQ ID NO: 51, the peptide having a length of 9 to 15 amino acid residues.

公开(公告)号：EP4258001A1

公开(公告)日：2023-10-11

申请号：EP21900657.4

申请日：2021-11-25

Applicant: OSAKA UNIVERSITY

Inventor： KIOKA, Hidetaka ,  TAKAHASHI, Yusuke ,  FUKUHARA, Shinichiro ,  SAKATA, Yasushi ,  NONOMURA, Norio ,  TAKASHIMA, Seiji ,  SAITO, Shigeyoshi

IPC: G01R33/46 ,  G01R33/485 ,  G01N24/08 ,  A61B5/055

Abstract: An evaluation method is performed by an arithmetic circuit and includes obtainment processing (S 1), evaluation processing (S2), and presentation processing (S3). The obtainment processing (S 1) obtains: image information on a sectional image representing an interested section of an organism including a target section of a testis of the organism generated by use of magnetic resonance of hydrogen atoms; and concentration information on a creatine concentration in the interested section measured by use of magnetic resonance based on chemical exchange saturation transfer. The evaluation processing (S2) generates an evaluation image representing a distribution of evaluation results of a testicular function in the target section based on the concentration information. The presentation processing (S3) presents the sectional image and the evaluation image.