公开(公告)号：EP2265616B1

公开(公告)日：2013-11-20

申请号：EP09709265.4

申请日：2009-02-06

申请人： OSI Pharmaceuticals, Inc.

发明人： MULVIHILL, Mark, J. ,  WANG, Jing ,  CHEN, Xin ,  WANG, Ti ,  LI, An-hu ,  STEINIG, Arno, G. ,  KLEINBERG, Andrew ,  WENG, Qinghua ,  DONG, Hanqing ,  JIN, Meizhong

IPC分类号： C07D491/048 ,  A61K31/4355 ,  A61P35/00

CPC分类号： C07D491/048

摘要： Furo[3,2-c]Pyridine and Thieno[3,2-c]pyridine compounds of Formula I, and pharmaceutically acceptable salts thereof, preparation, intermediates, pharmaceutical compositions, and use, such as in disease treatment, including cancers, including conditions in which EMT is involved, including conditions mediated by protein kinase activity such as RON and/or MET.

公开(公告)号：EP2356116A1

公开(公告)日：2011-08-17

申请号：EP09756112.0

申请日：2009-11-19

申请人： OSI Pharmaceuticals, Inc.

发明人： CHEN, Xin ,  JIN, Meizhong ,  KLEINBERG, Andrew ,  LI, An-hu ,  MULVIHILL, Mark, J. ,  STEINIG, Arno, G. ,  WANG, Jing

IPC分类号： C07D471/04 ,  A61K31/437 ,  A61P35/00

CPC分类号： C07D471/04

摘要： Compounds of Formula I, as shown below and defined herein:(I) pharmaceutically acceptable salts, synthesis, intermediates, formulations, and methods of disease treatment therewith, including cancers mediated at least in part by Ron and/or Met.

公开(公告)号：EP1807419B1

公开(公告)日：2009-05-27

申请号：EP05821171.5

申请日：2005-10-25

申请人： OSI Pharmaceuticals, Inc.

发明人： BLOXHAM, Jason ,  CREW, Andrew ,  HONDA, Ayako ,  LI, An-hu ,  PANICKER, Bijoy ,  TARDIBONO, Lawrence ,  WYNNE, Graham

IPC分类号： C07D409/12 ,  C07D409/14 ,  A61K31/47 ,  A61P35/00

CPC分类号： A61K31/381 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/4709 ,  A61K31/4745 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  A61K2300/00

摘要： Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.

公开(公告)号：EP2265616A1

公开(公告)日：2010-12-29

申请号：EP09709265.4

申请日：2009-02-06

申请人： OSI Pharmaceuticals, Inc.

发明人： MULVIHILL, Mark, J. ,  WANG, Jing ,  CHEN, Xin ,  WANG, Ti ,  LI, An-hu ,  STEINIG, Arno, G. ,  KLEINBERG, Andrew ,  WENG, Qinghua ,  DONG, Hanqing ,  JIN, Meizhong

IPC分类号： C07D491/048 ,  A61K31/4355 ,  A61P35/00

CPC分类号： C07D491/048

摘要： Furo[3,2-c]Pyridine and Thieno[3,2-c]pyridine compounds of Formula (I), and pharmaceutically acceptable salts thereof, preparation, intermediates, pharmaceutical compositions, and use, such as in disease treatment, including cancers, including conditions in which EMT is involved, including conditions mediated by protein kinase activity such as RON and/or MET.

公开(公告)号：EP1807419A1

公开(公告)日：2007-07-18

申请号：EP05821171.5

申请日：2005-10-25

申请人： OSI Pharmaceuticals, Inc.

发明人： BLOXHAM, Jason ,  CREW, Andrew ,  HONDA, Ayako ,  LI, An-hu ,  PANICKER, Bijoy ,  TARDIBONO, Lawrence ,  WYNNE, Graham

IPC分类号： C07D409/12 ,  C07D409/14 ,  A61K31/47 ,  A61P35/00

CPC分类号： A61K31/381 ,  A61K31/437 ,  A61K31/4436 ,  A61K31/4709 ,  A61K31/4745 ,  A61K45/06 ,  C07D409/12 ,  C07D409/14 ,  C07D471/04 ,  A61K2300/00

摘要： Amidoaryl/amidoheteroaryl substituted thiophenes, further substituted with a heteroarylmethylamino group, are useful in the treatment of cancer.

摘要翻译： 酰胺芳基/酰氨基杂芳基取代的噻吩，进一步被杂芳基甲基氨基取代，可用于治疗癌症。