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公开(公告)号：EP1957073B1
公开(公告)日：2014-04-23
申请号：EP06834365.6
申请日：2006-12-04
发明人： MATSUYAMA, Hironori , OHNISHI, Kenji , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , HIGUCHI, Kumi , MIYAJIMA, Keisuke , YAMADA, Satoshi , MOTOYAMA, Masaaki , KOJIMA, Yutaka , YASUMURA, Koichi , KODAMA, Takeshi , OTSUJI, Shun , KAN, Keizo , SUMIDA, Takumi
IPC分类号： A61K31/495 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61K31/495
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公开(公告)号：EP1957073A2
公开(公告)日：2008-08-20
申请号：EP06834365.6
申请日：2006-12-04
发明人： MATSUYAMA, Hironori , OHNISHI, Kenji , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , HIGUCHI, Kumi , MIYAJIMA, Keisuke , YAMADA, Satoshi , MOTOYAMA, Masaaki , KOJIMA, Yutaka , YASUMURA, Koichi , KODAMA, Takeshi , OTSUJI, Shun , KAN, Keizo , SUMIDA, Takumi
IPC分类号： A61K31/495 , A61K31/496 , A61P35/00
CPC分类号： A61K31/496 , A61K31/495
摘要： An object of the present invention is to provide a medicinal drug much improved in anti tumor activity and excellent in safety. According to the present invention, there is provided a medicinal drug containing a compound represented by the following general formula (1) or a salt thereof as an active ingredient: [Formula 1] wherein X1 represents a nitrogen atom or a group -CH=, R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5- to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)- or a lower alkylene group, and A represents [Formula 2] wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
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公开(公告)号：EP2089373A1
公开(公告)日：2009-08-19
申请号：EP07829383.4
申请日：2007-10-02
发明人： SEKIGUCHI, Kazuo , SUZUKI, Takashi , OHBUCHI, Yutaka , OKUNO, Mitsuhiro , OHI, Naoto , OHNISHI, Kenji , MOTOYAMA, Masaaki , YOSHIDA, Kenji , KODAMA, Takeshi , SUGIYAMA, Kazuhisa , AKAMATSU, Seiji , KIYONO, Kunihiko , YANAGIHARA, Yasuo , WATANABE, Takashi , HAYASHI, Kazuhiko , TANAKA, Hideo , SUMIDA, Takumi
IPC分类号： C07D317/58 , C07D405/12
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group -CH=, R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)-or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译： 本发明的目的是提供一种STAT3 / 5激活抑制剂。 本发明提供含有通式表示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂，式中，X1表示氮原子或基团-CH =，R1表示基团-Z-R6， 其中Z表示基团-CO-，基团-CH（OH） - 等，R 6表示具有1至4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基团，氧原子 或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，并且A表示其中R 3表示 氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。
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