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1.发明公开
公开(公告)号：EP0495131A1
公开(公告)日：1992-07-22
申请号：EP91914201.8
申请日：1991-08-09
发明人： NAKAI, Satoru, 67-4, Aza-Minamikawamukou , AKAMATSU, Seiji , MASUI, Yoshihiro, 1-50, Aza-Shimozao , NISHIDA, Tsutomu , KAMOGASHIRA, Takashi , HIRAI, Yoshikatu
CPC分类号： C07K14/545 , A61K38/00
摘要： An agent for preventing and treating hepatitis, containing at least one member selected among interleukin-1 and its derivatives as the active ingredient, which significantly inhibits the blood GOT and GPT activities as a marker for the onset of hepatitis and also suppresses the presentation of jaundice.
摘要翻译： 一种预防和治疗肝炎的药物，含有选自白介素-1及其衍生物中的至少一种作为活性成分，其显着抑制血液GOT和GPT活性，作为肝炎发病的标志物，并且还抑制黄疸的出现 。
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公开(公告)号：EP2089373A1
公开(公告)日：2009-08-19
申请号：EP07829383.4
申请日：2007-10-02
发明人： SEKIGUCHI, Kazuo , SUZUKI, Takashi , OHBUCHI, Yutaka , OKUNO, Mitsuhiro , OHI, Naoto , OHNISHI, Kenji , MOTOYAMA, Masaaki , YOSHIDA, Kenji , KODAMA, Takeshi , SUGIYAMA, Kazuhisa , AKAMATSU, Seiji , KIYONO, Kunihiko , YANAGIHARA, Yasuo , WATANABE, Takashi , HAYASHI, Kazuhiko , TANAKA, Hideo , SUMIDA, Takumi
IPC分类号： C07D317/58 , C07D405/12
CPC分类号： C07D401/12 , C07D213/38 , C07D401/04 , C07D405/12 , C07D405/14
摘要： An object of the present invention is to provide a STAT3/5 activation inhibitor. The present invention provides a STAT3/5 activation inhibitor containing an aromatic compound represented by the general formula or a salt thereof as an active ingredient: wherein X1 represents a nitrogen atom or a group -CH=, R1 represents a group -Z-R6, in which Z represents a group -CO-, a group -CH(OH)- or the like, R6 represents a 5-to 15-membered monocyclic, dicyclic or tricyclic saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms or sulfur atoms, R2 represents a hydrogen atom or a halogen atom, Y represents a group -O-, a group -CO-, a group -CH(OH)-or a lower alkylene group, and A represents a group wherein R3 represents a hydrogen atom, a lower alkoxy group or the like, p represents 1 or 2, R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译： 本发明的目的是提供一种STAT3 / 5激活抑制剂。 本发明提供含有通式表示的芳香族化合物或其盐作为有效成分的STAT3 / 5活化抑制剂，式中，X1表示氮原子或基团-CH =，R1表示基团-Z-R6， 其中Z表示基团-CO-，基团-CH（OH） - 等，R 6表示具有1至4个氮原子的5至15元单环，二环或三环饱和或不饱和杂环基团，氧原子 或硫原子，R 2表示氢原子或卤素原子，Y表示基团-O-，基团-CO-，基团-CH（OH） - 或低级亚烷基，并且A表示其中R 3表示 氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。
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公开(公告)号：EP0552373A1
公开(公告)日：1993-07-28
申请号：EP92914177.8
申请日：1992-07-02
发明人： NAKAI, Satoru , AIHARA, Koutoku , MORI, Hitomi , TOMINAGA, Michiaki , ADACHI, Masakazu , ICHIKAWA, Hiroyuki , AKAMATSU, Seiji , SAITO, Fumio
IPC分类号： A61K31/495
CPC分类号： A61K31/496 , A61K31/495
摘要： An apoptosis regulator containing a carbostyril derivative represented by general formula (1) and its salt as the active ingredient, wherein R represents benzoyl which may be substituted by lower alkoxy, and the carbon-to-carbon bond between the positions 3 and 4 of the carbostyril skeleton is either a single or a double bond.
摘要翻译： 含有通式（1）表示的喹诺酮衍生物及其盐作为活性成分的细胞凋亡调节剂，其中R表示可以被低级烷氧基取代的苯甲酰基，以及其中位置3和4之间的碳 - 碳键 喹诺酮骨架是单键或双键。
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公开(公告)号：EP1773797A2
公开(公告)日：2007-04-18
申请号：EP05780290.2
申请日：2005-08-03
发明人： FUKUSHIMA, Tae , MATSUMURA, Shuji, La Soreado 201 , TAKEMURA, Noriaki , SATOU, Hideaki , ITO, Nobuaki , SHITSUTA, Takuya , TSUTSUI, Hironori , TANAKA, Michinori , KAN, Keizo , NAGAO, Hitoshi , WATANABE, Kenji , TAI, Kuninori , NAKAGAWA, Takashi , TAKASU, Hideki , SAKAMOTO, Makoto , MIYAJIMA, Keisuke , YAMADA, Satoshi , KOJIMA, Yutaka , YASUMURA, Koichi , OHI, Naoto , OKUNO, Mitsuhiro , SUGIYAMA, Kazuhisa , KIYONO, Kunihiko , SUZUKI, Takashi , AKAMATSU, Seiji , KODAMA, Takeshi , YANAGIHARA, Yasuo , SUMIDA, Takumi
IPC分类号： C07D295/192 , C07D317/58 , C07D211/46 , C07D211/58 , C07D213/75
CPC分类号： C07C229/18 , C07C205/38 , C07C217/90 , C07C233/45 , C07C233/75 , C07C271/58 , C07C275/34 , C07C2601/02 , C07C2601/08 , C07C2601/14 , C07C2601/18 , C07D211/46 , C07D211/58 , C07D211/62 , C07D211/70 , C07D213/75 , C07D239/42 , C07D241/20 , C07D295/185 , C07D295/192 , C07D317/58 , C07D401/12 , C07D401/14 , C07D405/12 , C07D405/14 , C07D409/12 , C07D409/14 , C07D413/12 , C07D413/14 , C07D417/12 , C07D417/14
摘要： The present invention provides a novel compound, which has an excellent effect of suppressing the generation of collagen and less side effects, with being excellent in terms of safety. The compound of the present invention is represented by the following general formula (1): [wherein X1 represents a nitrogen atom or a group -CH=; R1 represents a group -Z-R6, wherein Z represents a group -CO-, a group -CH(OH)-, or the like, and R6 represents a 5- to 15-membered monocyclic, dicyclic, or tricyclic, saturated or unsaturated heterocyclic group having 1 to 4 nitrogen atoms, oxygen atoms, or sulfur atoms; R2 represents a hydrogen atom, a halogen atom or a lower alkylene group; Y represents a group -O-, a group -CO-, a group -CH(OH)-, a lower alkylene group, or the like; and (A) represents a group or the like, wherein R3 represents a hydrogen atom, a lower alkoxy group, or the like, p represents 1 or 2, and R4 represents an imidazolyl lower alkyl group or the like.
摘要翻译： 本发明提供了一种新颖的化合物，其在安全性方面优异，具有抑制胶原产生和副作用小的优异效果。 本发明的化合物由以下通式（1）表示：[其中X 1表示氮原子或基团-CH =; R 1表示基团-Z-R 6，其中Z表示-CO-基团，基团-CH（OH） - 等，R 6表示5至15元单环，双环或三环饱和或 具有1-4个氮原子的不饱和杂环基，氧原子或硫原子; R2表示氢原子，卤素原子或低级亚烷基; Y表示基团-O-，基团-CO-，基团-CH（OH） - ，低级亚烷基基团等; A表示基团等，其中R3表示氢原子，低级烷氧基等，p表示1或2，R4表示咪唑基低级烷基等。
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公开(公告)号：EP0623598A1
公开(公告)日：1994-11-09
申请号：EP94908099.8
申请日：1993-08-12
发明人： NAKAI, Satoru, 67-4, Aza Minamikawamukai , AIHARA, Koutoku , TANAKA, Hideo , IBA, Hitomi , KAWAI, Kazuyoshi, Haitsu-Soreiyu , ICHIKAWA, Hiroyuki , AKAMATSU, Seiji , SAITO, Fumio , TOMINAGA, Michiaki , ADACHI, Masakazu
IPC分类号： C07D215/22 , A61K31/495
CPC分类号： C07D215/227 , C07D215/38
摘要： Carbostyril derivatives represented by general formula (1), salts thereof, and an apoptosis regulator containing the same as the active ingredient, wherein R represents benzoyl, phenyl-substituted lower alkyl, etc.; R²⁰ represents hydrogen, lower alkyl, etc.; and R²¹ represents hydrogen, lower alkyl, etc. The regulator is useful as antitumor agent, antiretroviral agent, autoimmune disease remedy, immunosuppressant, Alzheimer's disease remedy, hepatic disease remedy, cancer metastasis inhibitor, and so forth.
摘要翻译： 由通式（1）表示的碳代苯甲酸酯衍生物，其盐，和含有与活性成分相同的凋亡调节剂，其中R代表苯甲酰基，苯基取代的低级烷基等; R 2表示氢，低级烷基等; R 2表示氢，低级烷基等。该调节剂可用作抗肿瘤药，抗逆转录病毒药，自身免疫疾病治疗药，免疫抑制剂，阿尔茨海默病治疗药，肝病治疗药，癌转移抑制剂等。
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公开(公告)号：EP0552373B1
公开(公告)日：1999-10-13
申请号：EP92914177.8
申请日：1992-07-02
发明人： NAKAI, Satoru , AIHARA, Koutoku , MORI, Hitomi , TOMINAGA, Michiaki , ADACHI, Masakazu , ICHIKAWA, Hiroyuki , AKAMATSU, Seiji , SAITO, Fumio
IPC分类号： A61K31/495
CPC分类号： A61K31/496 , A61K31/495
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公开(公告)号：EP0495131B1
公开(公告)日：1997-05-14
申请号：EP91914201.8
申请日：1991-08-09
发明人： NAKAI, Satoru, 67-4, Aza-Minamikawamukou , AKAMATSU, Seiji , MASUI, Yoshihiro, 1-50, Aza-Shimozao , NISHIDA, Tsutomu , KAMOGASHIRA, Takashi , HIRAI, Yoshikatu
CPC分类号： C07K14/545 , A61K38/00
摘要： An agent for preventing and treating hepatitis, containing at least one member selected among interleukin-1 and its derivatives as the active ingredient, which significantly inhibits the blood GOT and GPT activities as a marker for the onset of hepatitis and also suppresses the presentation of jaundice.
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