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1.发明授权MPROVED PROCESS FOR PRODUCTION OF FIBRINOGEN AND FIBRINOGEN PRODUCED THEREBY 有权生产纤维蛋白原和由其产生的纤维蛋白原的MPROVED方法
公开(公告)号：EP2825555B1
公开(公告)日：2017-07-12
申请号：EP13709190.6
申请日：2013-03-12
申请人： Octapharma AG
发明人： SCHULZ, Petra , GEHRINGER, Werner , PAPE, Rainer , LEITINGER, Caroline , SCHÖN, Friedrich , RÖMISCH, Jürgen
IPC分类号： C07K14/75
摘要： A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing solution in the presence of one or more chelating agent(s) and removal of the supernatant from the fibrinogen paste, characterised in that fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen, and an undissolved residue, which is separated from the liquid.
摘要翻译： 一种通过在一种或多种螯合剂存在下通过沉淀剂从含有纤维蛋白原的溶液中沉淀纤维蛋白原并从纤维蛋白原糊中除去上清液从含纤维蛋白原源中纯化纤维蛋白原的方法，其特征在于纤维蛋白原为 从糊状物中提取，形成含纤维蛋白原的液体部分和从液体中分离出的未溶解的残余物。
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2.发明公开IMPROVED PROCESS FOR PRODUCTION OF FIBRINOGEN AND FIBRINOGEN PRODUCED THEREBY 有权VERBESSERTES VERFAHREN ZUR FIBRINOGENHERSTELLUNG UNDE DADURCH HERGESTELLTES FIBRINOGEN
公开(公告)号：EP2825555A1
公开(公告)日：2015-01-21
申请号：EP13709190.6
申请日：2013-03-12
申请人： Octapharma AG
发明人： SCHULZ, Petra , GEHRINGER, Werner , PAPE, Rainer , LEITINGER, Caroline , SCHÖN, Friedrich , RÖMISCH, Jürgen
IPC分类号： C07K14/75
摘要： A process for purifying fibrinogen from a fibrinogen containing source by precipitation of fibrinogen by a precipitating agent from a fibrinogen containing solution in the presence of one or more chelating agent(s) and removal of the supernatant from the fibrinogen paste, characterised in that fibrinogen is extracted from the paste forming a liquid fraction containing fibrinogen, and an undissolved residue, which is separated from the liquid.
摘要翻译： 一种通过在一种或多种螯合剂存在下由含纤维蛋白原溶液沉淀纤维蛋白原的纤维蛋白原来净化纤维蛋白原的方法，并从纤维蛋白原浆糊中除去上清液，其特征在于纤维蛋白原为 从形成含有纤维蛋白原的液体部分的糊剂中提取，以及与液体分离的未溶解残余物。
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公开(公告)号：EP1654284B1
公开(公告)日：2009-04-15
申请号：EP04764046.1
申请日：2004-08-12
申请人： Octapharma AG
发明人： SCHULZ, Petra , RÖMISCH, Jürgen
CPC分类号： A61L2/0088 , A61L2/0017 , A61L2/0023 , C07K14/8125
摘要： A process for preparing A1AT from A1AT-containing solutions, comprising the following steps: (a) subjecting an A1AT-containing solution to ion-exchange chromatography; (b) adding detergents and optionally a solvent for inactivating lipid-enveloped viruses; (c) followed by increasing the salt concentration to salt out the detergents. A1AT having a purity of > 90% with an activity of > 0.8 PEU/mg in its active form.
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公开(公告)号：EP2619225B1
公开(公告)日：2016-06-15
申请号：EP11757875.7
申请日：2011-09-20
申请人： Octapharma AG
发明人： PAPE, Rainer , GEHRINGER, Werner , SCHULZ, Petra
IPC分类号： C07K14/75
摘要： The present invention relates to a method or process for the manufacture of a virus and prion save native fibrinogen concentrate of high purity and low amounts of fibrinopeptide A and fibronectin.
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公开(公告)号：EP3817765A1
公开(公告)日：2021-05-12
申请号：EP19748475.1
申请日：2019-07-08
申请人： Octapharma AG
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公开(公告)号：EP3590528A1
公开(公告)日：2020-01-08
申请号：EP19153624.2
申请日：2019-01-24
申请人： Octapharma AG
发明人： RÖMISCH, Jürgen Roland , POCK, Katharina , SCHULZ, Petra , WUSCHKO, Silvio , ANDESNER, Michael , MURANYI, Andrej
摘要： The invention relates to a high purity Coagulation Factor Xa (FXa or activated Coagulation Factor X) preparation and an activation and purification process to obtain said FXa of high purity and high degree of activation without addition of proteinaceous activators during manufacturing.
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公开(公告)号：EP2627348A1
公开(公告)日：2013-08-21
申请号：EP11770100.3
申请日：2011-10-13
申请人： Octapharma AG
IPC分类号： A61K38/17 , C07K1/18 , C07K14/435
CPC分类号： C07K14/472 , A61K38/1709 , C07K1/36 , C07K14/435 , C07K14/47
摘要： A method for purification of complement Factor H from a complement Factor H containing source such as blood or blood plasma, in particular a caprylate precipitate of a Factor H containing source, which is e.g. obtained by addition of caprylate ions to fractions of blood or plasma, comprising the steps of: a)providing a Factor H containing source, in particular reconstitution of caprylate precipitate to provide a complement Factor H containing solution; b)performing a cation exchange chromatography in particular as first chromatographic step; c)performing an anion exchange chromatography; d)performing a hydroxyl apatite chromatography; e)followed by ultra/diafiltration to obtain a complement Factor H concentrate.
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公开(公告)号：EP1654284A1
公开(公告)日：2006-05-10
申请号：EP04764046.1
申请日：2004-08-12
申请人： Octapharma AG
发明人： SCHULZ, Petra , RÖMISCH, Jürgen
CPC分类号： A61L2/0088 , A61L2/0017 , A61L2/0023 , C07K14/8125
摘要： A process for preparing A1AT from A1AT-containing solutions, comprising the following steps: (a) subjecting an A1AT-containing solution to ion-exchange chromatography; (b) adding detergents and optionally a solvent for inactivating lipid-enveloped viruses; (c) followed by increasing the salt concentration to salt out the detergents. A1AT having a purity of > 90% with an activity of > 0.8 PEU/mg in its active form.
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