公开(公告)号：EP3838901A1

公开(公告)日：2021-06-23

申请号：EP19849263.9

申请日：2019-08-15

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： KOUJI Hiroyuki ,  YAMADA Kentaro ,  KATO Akira ,  ISHIZAKI Toshimasa ,  MATSUOKA Shigeru ,  NISHIZONO Akira ,  MISHINA Tadashi ,  YOSHIMORI Atsushi

IPC分类号： C07D471/08 ,  A61K31/439 ,  A61P31/14 ,  C07D487/18

摘要： The present disclosure provides a compound that is useful for the treatment and prevention of rabies. The present disclosure provides a compound represented by formula IF or formula IB:

wherein R 1 , R 2 , R 3 , and R 4 are defined in the specification, a solvate, or a pharmaceutically acceptable salt thereof, use of such compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prevention of rabies, a pharmaceutical composition comprising such compound, solvate, or pharmaceutically acceptable salt thereof, and a method for treating or preventing rabies using the same.

公开(公告)号：EP4104902A1

公开(公告)日：2022-12-21

申请号：EP20918971.1

申请日：2020-02-14

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： KOUJI Hiroyuki ,  YAMADA Kentaro ,  KATOH, Akira ,  ISHIZAKI Toshimasa ,  MATSUOKA Shigeru ,  NISHIZONO Akira ,  MISHINA Tadashi ,  YOSHIMORI Atsushi

IPC分类号： A61P31/14 ,  C07D471/08 ,  A61K31/439

摘要： The present disclosure provides a compound that is useful for the treatment and prophylaxis of rabies. The present disclosure provides a compound represented by formula XXIF or formula XXIB:

wherein R 1 , R 2A , R 2B , R 3 , and R 4 are defined in the specification, a solvent, or a pharmaceutically acceptable salt thereof, use of such a compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prophylaxis of rabies and cancer, a pharmaceutical composition comprising such a compound, solvate, or pharmaceutically acceptable salt thereof, and a method for the treatment or prophylaxis of rabies and cancer using the same.