公开(公告)号：EP3838901A1

公开(公告)日：2021-06-23

申请号：EP19849263.9

申请日：2019-08-15

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： KOUJI Hiroyuki ,  YAMADA Kentaro ,  KATO Akira ,  ISHIZAKI Toshimasa ,  MATSUOKA Shigeru ,  NISHIZONO Akira ,  MISHINA Tadashi ,  YOSHIMORI Atsushi

IPC分类号： C07D471/08 ,  A61K31/439 ,  A61P31/14 ,  C07D487/18

摘要： The present disclosure provides a compound that is useful for the treatment and prevention of rabies. The present disclosure provides a compound represented by formula IF or formula IB:

wherein R 1 , R 2 , R 3 , and R 4 are defined in the specification, a solvate, or a pharmaceutically acceptable salt thereof, use of such compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prevention of rabies, a pharmaceutical composition comprising such compound, solvate, or pharmaceutically acceptable salt thereof, and a method for treating or preventing rabies using the same.

公开(公告)号：EP4261830A1

公开(公告)日：2023-10-18

申请号：EP21903440.2

申请日：2021-12-08

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： KOUJI, Hiroyuki ,  YOSHIMORI, Atsushi

IPC分类号： G16C20/50 ,  C07D471/08 ,  C07K1/00

摘要： The present disclosure provides a design and synthesis of a useful carbon skeleton, a design and synthesis of a peptidomimetic molecule and applications and uses based thereon. More particularly, provided is a method for designing a compound skeleton with a desired structure, said method comprising, with the use of a computer: (1) a step for generating a molecular formula of a carbon-containing compound; (2) a step for randomly synthesizing molecules using the adjacency matrix and extracting compounds that correspond to the molecular formula among the randomly synthesized molecules; and (3) a step for selecting a compound that satisfies preset conditions.

公开(公告)号：EP4104902A1

公开(公告)日：2022-12-21

申请号：EP20918971.1

申请日：2020-02-14

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： KOUJI Hiroyuki ,  YAMADA Kentaro ,  KATOH, Akira ,  ISHIZAKI Toshimasa ,  MATSUOKA Shigeru ,  NISHIZONO Akira ,  MISHINA Tadashi ,  YOSHIMORI Atsushi

IPC分类号： A61P31/14 ,  C07D471/08 ,  A61K31/439

摘要： The present disclosure provides a compound that is useful for the treatment and prophylaxis of rabies. The present disclosure provides a compound represented by formula XXIF or formula XXIB:

wherein R 1 , R 2A , R 2B , R 3 , and R 4 are defined in the specification, a solvent, or a pharmaceutically acceptable salt thereof, use of such a compound, solvate, or pharmaceutically acceptable salt thereof for the treatment or prophylaxis of rabies and cancer, a pharmaceutical composition comprising such a compound, solvate, or pharmaceutically acceptable salt thereof, and a method for the treatment or prophylaxis of rabies and cancer using the same.

公开(公告)号：EP3978076A1

公开(公告)日：2022-04-06

申请号：EP20818114.9

申请日：2020-06-03

申请人： Oita University Institute of Advanced Medicine, Inc.

发明人： MATSUOKA, Shigeru ,  KATOH, Akira ,  MISHINA, Tadashi ,  YAMADA, Kentaro ,  YOSHIMORI, Atsushi ,  ISHIZAKI, Toshimasa ,  NISHIZONO, Akira ,  KOUJI, Hiroyuki

IPC分类号： A61P31/14 ,  C07D471/18 ,  A61K31/439

摘要： The present disclosure provides compounds useful in the treatment and prevention of rabies. The present disclosure provides compounds represented by formula XXIF or XXIB

[in the formulas, R 1 , R 2A , R 2B , R 3 , and R 4 are as defined in the specification], solvates or pharmaceutically acceptable salts thereof, the use of these compounds, solvates or pharmaceutically acceptable salts thereof to treat or prevent rabies, pharmaceutical compositions including these compounds, solvates or pharmaceutically acceptable salts thereof, and a method for treating and preventing rabies using the same.