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    Dietary compositions and methods using bile salt-activated lipase
    1.
    发明公开
    Dietary compositions and methods using bile salt-activated lipase 失效
    Diätzusammensetzungenund Verfahren zur Verwendung vonGallsäureaktivierter脂肪酶。

    公开(公告)号：EP0317355A2

    公开(公告)日：1989-05-24

    申请号：EP88310942.3

    申请日：1988-11-18

    申请人： Oklahoma Medical Research Foundation

    发明人： Tang, Jordan J.N. ,  Wang, Chi-Sun

    IPC分类号： A23C9/20 ,  A23C9/12 ,  A23L1/03 ,  A61K37/54

    CPC分类号： C12Y301/01003 ,  A23C9/1216 ,  A23C9/20 ,  A23L29/06 ,  A23L33/17 ,  Y10S426/801

    摘要： Dietary compositions, especially cow's milk-based infant formulas, are fortified with bile salt-activated lipase. Methods are provided for feeding newborn and premature infants which include administration of bile salt-activated lipase to increase fat digestion and therefore growth rate. Similarly, a method is provided to treat subjects for inadequate pancreatic enzyme production by administration of bile salt-activated lipase in conjunction with ingestion of fats.

    摘要翻译： 膳食组合物，特别是牛奶的婴儿配方，用胆汁盐激活的脂肪酶加强。 提供用于喂养新生儿和早产儿的方法，其包括施用胆汁盐活化的脂肪酶以增加脂肪消化并因此增长。 类似地，提供了一种通过与摄取脂肪一起施用胆汁盐激活的脂肪酶来治疗受试者不足的胰酶生产的方法。

    Recombinant bile salt activated lipases
    3.
    发明公开
    Recombinant bile salt activated lipases 失效
    重组通过胆汁盐激活的脂肪酶

    公开(公告)号：EP0861897A3

    公开(公告)日：1999-05-12

    申请号：EP98200772.6

    申请日：1991-04-04

    申请人： Oklahoma Medical Research Foundation

    发明人： Tang, Jordan J N ,  Wang, Chi-Sun

    IPC分类号： C12N15/55 ,  C12N9/18 ,  A01K67/027

    CPC分类号： A23C9/20 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/10 ,  A01K2267/01 ,  A23C9/1216 ,  A23L33/17 ,  C12N9/18 ,  C12N15/8509 ,  C12Y301/01003

    摘要： The complete structure of human milk BAL cDNA is disclosed. The nucleotide sequences of the cDNA inserts of two clones overlap and together contain 2951 base pairs of BAL cDNA which codes for an open reading frame of 720 amino acid residues between initiation and termination codons. There is a putative signal sequence of 20 residues which is followed by a 61-amino-terminal sequence of BAL. The cDNA sequence also contains a 678-base 5'-untranslated sequence, a 96-base 3'-untranslated region, and a 14-base poly(A) tail. The deduced BAL protein structure contains in the carboxyl-terminal region fourteen repeating units of 11 amino acids each. The repeating units have the basic structure of Pro-Val-Pro-Pro-Thr-Gly-Asp-Ser-Gly-Ala-Pro-, with only minor substitutions. The cDNA is useful for expression of protein, study of structure, function and the effect of modification or deletion or addition of amino acids, including entire repeating units, and as probes for studies involving BAL or related lipases, including rat pancreatic lysophospholipase, cholinesterase, and acetylcholinesterase.

    Recombinant bile salt activated lipases
    8.
    发明公开
    Recombinant bile salt activated lipases 失效
    Rekombinante durch Gallensalz aktivierte Lipasen

    公开(公告)号：EP0861897A2

    公开(公告)日：1998-09-02

    申请号：EP98200772.6

    申请日：1991-04-04

    申请人： Oklahoma Medical Research Foundation

    发明人： Tang, Jordan J N ,  Wang, Chi-Sun

    IPC分类号： C12N15/55 ,  C12N9/18 ,  A01K67/027

    CPC分类号： A23C9/20 ,  A01K2207/15 ,  A01K2217/00 ,  A01K2227/10 ,  A01K2267/01 ,  A23C9/1216 ,  A23L33/17 ,  C12N9/18 ,  C12N15/8509 ,  C12Y301/01003

    摘要： The complete structure of human milk BAL cDNA is disclosed. The nucleotide sequences of the cDNA inserts of two clones overlap and together contain 2951 base pairs of BAL cDNA which codes for an open reading frame of 720 amino acid residues between initiation and termination codons. There is a putative signal sequence of 20 residues which is followed by a 61-amino-terminal sequence of BAL. The cDNA sequence also contains a 678-base 5'-untranslated sequence, a 96-base 3'-untranslated region, and a 14-base poly(A) tail. The deduced BAL protein structure contains in the carboxyl-terminal region fourteen repeating units of 11 amino acids each. The repeating units have the basic structure of Pro-Val-Pro-Pro-Thr-Gly-Asp-Ser-Gly-Ala-Pro-, with only minor substitutions. The cDNA is useful for expression of protein, study of structure, function and the effect of modification or deletion or addition of amino acids, including entire repeating units, and as probes for studies involving BAL or related lipases, including rat pancreatic lysophospholipase, cholinesterase, and acetylcholinesterase.

    摘要翻译： 公开了人乳BAL cDNA的完整结构。 两个克隆的cDNA插入片段的核苷酸序列重叠并一起含有2951个碱基对的BAL cDNA，其编码起始和终止密码子之间的720个氨基酸残基的开放阅读框。 存在20个残基的推定信号序列，其后是BAL的61个氨基末端序列。 cDNA序列还含有678碱基的5'-非翻译序列，96碱基3'非翻译区和14碱基聚（A）尾。 推测的BAL蛋白结构在羧基末端区域中含有11个氨基酸的14个重复单元。 重复单元具有Pro-Val-Pro-Pro-Thr-Gly-Asp-Ser-Gly-Ala-Pro-的基本结构，只有很少的取代。 该cDNA可用于表达蛋白质，研究结构，功能以及修饰或缺失或添加氨基酸（包括整个重复单元）的作用，以及用于涉及BAL或相关脂肪酶的研究的探针，包括大鼠胰腺溶血磷脂酶，胆碱酯酶， 和乙酰胆碱酯酶。