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1.发明公开
公开(公告)号：EP3525798A1
公开(公告)日：2019-08-21
申请号：EP17861108.3
申请日：2017-10-12
IPC分类号： A61K31/7105 , A61K39/00 , A61K39/395 , A61K45/00 , A61K48/00 , A61P7/00
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2.发明授权METHODS FOR TREATING DISSEMINATED INTRAVASCULAR COAGULATION BY INHIBITING MASP-2 DEPENDENT COMPLEMENT ACTIVATION 有权VERFAHREN ZUR BEHANDLUNG VON DISSEMINITERTER INTRAVASALER KOAGULOPATHIE DURCH HEMMUNG MASP-2-ABHÄNGIGERKOMPLEMENTAKTIVIERUNG
公开(公告)号：EP2488203B1
公开(公告)日：2016-12-07
申请号：EP10824223.1
申请日：2010-10-15
发明人： SCHWAEBLE, Hans-Wilhelm , DUDLER, Thomas, A. , TEDFORD, Clark, E. , PARENT, James, B. , DEMOPULOS, Gregory, A.
IPC分类号： C07K16/40
CPC分类号： C07K16/40 , A61K2039/505 , C07K2317/21 , C07K2317/24 , C07K2317/54 , C07K2317/55 , C07K2317/76 , C07K2317/92 , C12Y304/21104
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公开(公告)号：EP3468587A1
公开(公告)日：2019-04-17
申请号：EP17810882.5
申请日：2017-06-06
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4.发明授权COMPOSITIONS AND METHODS OF INHIBTING MASP-1 AND/OR MASP-3 FOR THE TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 有权抑制MASP-1和/或MASP-3治疗阵发性血红蛋白尿症的组合物和方法
公开(公告)号：EP2833907B1
公开(公告)日：2018-02-28
申请号：EP13798222.9
申请日：2013-04-05
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3-dependent complement activation in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3-dependent complement activation. In another aspect, the invention provides methods and compositions for increasing the survival of red blood cells in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of at least one of a MASP-1 inhibitory agent and/or a MASP-3 inhibitory agent effective to increase the survival of red blood cells. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
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5.发明公开COMPOSITIONS AND METHODS OF INHIBITING MASP-1 AND/OR MASP-2 AND/OR MASP-3 FOR THE TREATMENT OF VARIOUS DISEASES AND DISORDERS 审中-公开组合物和用于抑制方法MASP-1和/或MASP-2和/或MASP-3多种疾病和病症的治疗
公开(公告)号：EP2861246A2
公开(公告)日：2015-04-22
申请号：EP13807326.7
申请日：2013-06-18
IPC分类号： A61K39/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K45/06 , A61K2039/505 , C07K16/18 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3 -dependent complement activation in a subject suffering from or at risk for developing, a disease or disorder selected from the group consisting of paroxysmal nocturnal hemoglobinuria, age-related macular degeneration, arthritis, disseminated intravascular coagulation, thrombotic microangiopathy, asthma, dense deposit disease, pauci-immune necrotizing crescentic glomerulonephritis, traumatic brain injury, aspiration pneumonia, endophthalmitis, neuromyelitis optica and Behcet's disease by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3 -dependent complement activation. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
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6.发明公开COMPOSITIONS AND METHODS OF INHIBTING MASP-1 AND/OR MASP-3 FOR THE TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA 有权组合物和用于抑制方法MASP-1和/或MASP-3用于治疗阵发性夜间血红蛋白尿
公开(公告)号：EP2833907A2
公开(公告)日：2015-02-11
申请号：EP13798222.9
申请日：2013-04-05
IPC分类号： A61K39/00
CPC分类号： C07K16/40 , A61K39/3955 , A61K2039/505 , C07K16/468 , C07K2317/21 , C07K2317/31 , C07K2317/33 , C07K2317/54 , C07K2317/622 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods and compositions for inhibiting MASP-3 -dependent complement activation in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of a MASP-3 inhibitory agent in an amount effective to inhibit MASP-3 - dependent complement activation. In another aspect, the invention provides methods and compositions for increasing the survival of red blood cells in a subject suffering from paroxysmal nocturnal hemoglobinuria by administering to the subject a composition comprising an amount of at least one of a MASP-1 inhibitory agent and/or a MASP-3 inhibitory agent effective to increase the survival of red blood cells. In some embodiments, the subject is administered a MASP-2 inhibitory agent and a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent administered, a MASP-3 inhibitory agent and a MASP-1 inhibitory agent, or a MASP-1 inhibitory agent, a MASP-2 inhibitory agent and a MASP-3 inhibitory agent.
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8.发明公开
公开(公告)号：EP3490603A1
公开(公告)日：2019-06-05
申请号：EP17837477.3
申请日：2017-07-31
发明人： CUMMINGS, W., Jason , DEMOPULOS, Gregory, A. , DUDLER, Thomas , SCHWAEBLE, Hans-Wilhelm , TJOELKER, Larry, W. , WOOD, Christi, L. , YABUKI, Munehisa
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
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公开(公告)号：EP3436072A1
公开(公告)日：2019-02-06
申请号：EP17776787.8
申请日：2017-03-31
IPC分类号： A61K39/395 , A61P7/00 , A61P27/02 , C07K16/40
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公开(公告)号：EP3400012A1
公开(公告)日：2018-11-14
申请号：EP17736341.3
申请日：2017-01-05
IPC分类号： A61K39/395 , A61K45/06 , C07K16/40
CPC分类号： A61K39/3955 , A61K39/395 , A61K2039/505 , A61K2121/00 , C07K16/40 , C07K2317/21 , C07K2317/34 , C07K2317/54 , C07K2317/76 , C07K2317/92
摘要： In one aspect, the invention provides methods for treating, inhibiting, alleviating or preventing fibrosis in a mammalian subject suffering, or at risk of developing a disease or disorder caused or exacerbated by fibrosis and/or inflammation. In one embodiment, the invention provides methods of treating a subject suffering from renal fibrosis. In one embodiment, the invention provides methods of reducing proteinuria in a subject suffering from a renal disease or condition associated with proteinuria. The methods comprise the step of administering, to a subject in need thereof, an amount of a MASP-2 inhibitory agent effective to inhibit MASP-2-dependent complement activation.
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