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    MACROCYCLIC LRRK2 KINASE INHIBITORS
    1.
    发明授权
    MACROCYCLIC LRRK2 KINASE INHIBITORS 有权

    公开(公告)号：EP3194405B1

    公开(公告)日：2018-12-26

    申请号：EP15766801.3

    申请日：2015-09-17

    申请人： Oncodesign S.A.

    发明人： HOFLACK, Jan ,  BLOM, Petra ,  LAVERGNE, Olivier ,  GOMEZ, Sylvie

    IPC分类号： C07D487/22 ,  C07D498/22 ,  A61K31/529 ,  A61P25/28

    CPC分类号： C07D498/22 ,  C07D487/22

    摘要： The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.

    MACROCYCLIC RIP2 KINASE INHIBITORS
    2.
    发明公开
    MACROCYCLIC RIP2 KINASE INHIBITORS 审中-公开
    MACROCYCLIC RIP2激酶抑制剂

    公开(公告)号：EP3194407A1

    公开(公告)日：2017-07-26

    申请号：EP15766800.5

    申请日：2015-09-17

    申请人： Oncodesign S.A.

    发明人： HOFLACK, Jan ,  BLOM, Petra ,  BENDERITTER, Pascal

    IPC分类号： C07D498/22 ,  A61K31/529 ,  A61P29/00

    CPC分类号： C07D498/22

    摘要： The present invention relates to macrocyclic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of RIP2 and/or mutants thereof, for use in the diagnosis, prevention and/or treatment of RIP2-kinase associated diseases. Moreover, the present invention provides methods of using said compounds, for instance as a medicine or diagnostic agent.

    摘要翻译： 本发明涉及大环化合物和含有用作激酶抑制剂的所述化合物的组合物，特别是用作RIP2和/或其突变体的抑制剂，用于诊断，预防和/或治疗RIP2-激酶相关疾病。 而且，本发明提供了使用所述化合物的方法，例如作为药物或诊断剂。

    MACROCYCLIC LRRK2 KINASE INHIBITORS
    3.
    发明公开
    MACROCYCLIC LRRK2 KINASE INHIBITORS 有权
    MACROCYCLIC LRRK2激酶抑制剂

    公开(公告)号：EP3194405A1

    公开(公告)日：2017-07-26

    申请号：EP15766801.3

    申请日：2015-09-17

    申请人： Oncodesign S.A. ,  IPSEN PHARMA S.A.S.

    发明人： HOFLACK, Jan ,  BLOM, Petra ,  LAVERGNE, Olivier ,  GOMEZ, Sylvie

    IPC分类号： C07D487/22 ,  C07D498/22 ,  A61K31/529 ,  A61P25/28

    CPC分类号： C07D498/22 ,  C07D487/22

    摘要： The present invention relates to novel macrocyclic compounds of formula (I) and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.

    摘要翻译： 本发明涉及式（I）的新型大环化合物和含有作为激酶抑制剂的所述化合物的组合物，特别是作为LRRK2（富含亮氨酸的重复激酶2）的抑制剂的组合物。 此外，本发明提供了制备所公开化合物的方法以及使用它们的方法，例如作为药物或诊断剂，特别是用于治疗和/或诊断以LRRK2激酶活性为特征的疾病的方法，所述疾病例如 包括帕金森病和阿尔茨海默氏病在内的神经系统疾病。

    MACROCYCLIC LRRK2 KINASE INHIBITORS
    4.
    发明公开
    MACROCYCLIC LRRK2 KINASE INHIBITORS 有权
    MAKROCYCLISCHE LRRK2-KINASEHEMMER

    公开(公告)号：EP2760453A1

    公开(公告)日：2014-08-06

    申请号：EP12798824.4

    申请日：2012-09-28

    申请人： IPSEN PHARMA S.A.S. ,  Oncodesign S.A.

    发明人： HOFLACK, Jan ,  BLOM, Petra

    IPC分类号： A61K31/504 ,  A61K31/505 ,  C07D487/18 ,  C07D498/18 ,  C07D515/18 ,  A61P25/28

    CPC分类号： A61K31/519 ,  C07D487/16 ,  C07D487/18 ,  C07D498/16 ,  C07D498/18 ,  C07D498/22 ,  C07D515/16

    摘要： The present invention relates to novel macrocylic compounds and compositions containing said compounds acting as kinase inhibitors, in particular as inhibitors of LRRK2 (Leucine-Rich Repeat Kinase 2). Moreover, the present invention provides processes for the preparation of the disclosed compounds, as well as methods of using them, for instance as a medicine or diagnostic agent, in particular for the treatment and/or diagnosis of diseases characterized by LRRK2 kinase activity such as neurological disorders including Parkinson's disease and Alzheimer's disease.

    摘要翻译： 本发明涉及新的大环化合物和含有所述化合物作为激酶抑制剂的组合物，特别是作为LRRK2（富含亮氨酸重复激酶2）的抑制剂。 此外，本发明提供了制备所公开的化合物的方法，以及其使用方法，例如作为药物或诊断剂，特别是用于治疗和/或诊断以LRRK2激酶活性为特征的疾病，例如 神经障碍包括帕金森病和阿尔茨海默病。