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1.发明公开MODULATING INTERSTITIAL PRESSURE AND ONCOLYTIC VIRAL DELIVERY AND DISTRIBUTION 审中-公开调制间质压力和溶瘤病毒释放和分配
公开(公告)号：EP2296678A1
公开(公告)日：2011-03-23
申请号：EP09753371.5
申请日：2009-05-27
IPC分类号： A61K35/76 , A61K31/337 , A61K31/436 , A61K31/555 , A61K31/675 , A61K38/20 , A61P35/00 , A61K41/00
CPC分类号： A61K31/555 , A61K31/337 , A61K31/436 , A61K31/675 , A61K35/765 , A61K38/2013 , C12N2720/12032 , A61K2300/00
摘要： Provided herein are methods of treating a proliferative disorder in a subject comprising decreasing interstitial pressure and/or increasing vascular permeability in the subject and administering to the subject an oncolytic virus. Such methods improve oncolytic viral delivery and distribution.
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2.发明公开ABROGATING PROINFLAMMATORY CYTOKINE PRODUCTION DURING ONCOLYTIC REOVIRUS THERAPY 审中-公开停产促炎细胞因子的过程中与溶瘤呼肠孤病毒治疗
公开(公告)号：EP2296679A1
公开(公告)日：2011-03-23
申请号：EP09753372.3
申请日：2009-05-27
IPC分类号： A61K35/76 , A61K31/555 , A61K33/24 , A61P35/00
CPC分类号： A61K35/765 , A61K31/282 , A61K31/555 , A61K33/24 , C12N2720/12032 , A61K2300/00
摘要： Provided herein are methods for treating a proliferative disorder in a subject comprising administering to the subject one or more reoviruses and one or more agents that modulate expression or activity of pro-inflammatory cytokines. For example, the agents may inhibit expression or activity of pro-inflammatory cytokines.
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