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    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders
    9.
    发明公开
    Methods for preventing reovirus recognition for the treatment of cellular proliferative disorders 审中-公开
    为了防止呼肠孤病毒识别细胞紊乱高利贷的治疗方法

    公开(公告)号：EP2016948A3

    公开(公告)日：2009-01-28

    申请号：EP08006362.1

    申请日：2001-07-20

    申请人： Oncolytics Biotech Inc.

    发明人： Coffey, Matthew ,  Thompson, Bradley

    IPC分类号： A61K35/76 ,  A61P35/00

    CPC分类号： A61K35/765 ,  A61K38/13 ,  C07K16/081 ,  C07K16/10 ,  C07K16/4216 ,  C12N9/1205 ,  C12N2720/12232 ,  Y10S435/948 ,  Y10S435/975 ,  A61K2300/00

    摘要： The present invention pertains to methods for preventing reovirus recognition in the treatment of cellular proliferative disorders, and particularly ras-mediated cellular proliferative disorders, in mammals. The mammal may be selected from dogs, cats, sheep, goats, cattle, horses, pigs, mice, humans and non-human primates. The method comprises suppressing or otherwise inhibiting the immune system of the mammal and, concurrently or subsequently, administering to the proliferating cells an effective amount of one or more reoviruses under conditions which result in substantial lysis of the proliferating cells. In particular, the methods provide for reovirus treatment of immunosuppressed or immuno-deficient mammals to treat the proliferative disorders. Immunosuppression, immunoinhibition or otherwise inducing an immunodeficient state in a mammal renders the reovirus more effective. The methods may include the selective removal of immune constituents that may interfere with the systemic delivery of the virus; preventing reovirus recognition by the host immune system; and removal of the virus from an immune suppressed or immune incompetent host following treatment with reovirus. Alternatively, reovirus may be administered to a mammal with a diminished immune response system under conditions which result in substantial lysis of the proliferating cells. Immune systems may be compromised by one or more of the following: an HIV infection; as a side effect of chemotherapy or radiation therapy; by selective removal of B and/or T cell populations; by removal of antibodies (anti-antireovirus antibodies or all antibodies), and the like.

    摘要翻译： 本发明涉及在哺乳动物中用于细胞增殖性疾病的治疗中预防呼肠孤病毒的识别方法，并且特别的ras介导的细胞增殖性病症。 哺乳动物可以从狗，猫，绵羊，山羊，牛，马，猪，老鼠，人类和非人类的灵长类动物进行选择。 该方法包括抑制或以其它方式抑制哺乳动物的免疫系统，并且同时或随后，在有效量的一种或多种呼肠孤病毒，其导致增殖细胞的显着的裂解条件下给予所述增殖细胞。 特别地，该方法提供了呼肠孤病毒治疗免疫抑制或免疫缺陷的哺乳动物来治疗增殖性疾病。 免疫抑制，免疫抑制或以其他方式诱导在哺乳动物免疫缺损状态呈现呼肠孤病毒更有效。 该方法可以包括选择性地去除免疫组分也可以与病毒的全身性递送的干扰; 通过宿主免疫系统预防呼肠孤病毒识别; 并去除免疫抑制或免疫无能病毒的宿主与呼肠孤病毒治疗后。 可替代地，呼肠孤病毒可能，这导致增殖细胞的显着的裂解的条件下被施用到具有降低的免疫应答系统的哺乳动物。 免疫系统可以由一个或多个以下的妥协：HIV感染; 如化学疗法或放射疗法的副作用; 通过选择性地去除B和/或T细胞群的; 通过除去抗体（抗antireovirus抗体或所有抗体），以及类似物。