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公开(公告)号：EP3281664B1
公开(公告)日：2020-11-18
申请号：EP17190469.1
申请日：2013-02-25
申请人： Optinose AS
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公开(公告)号：EP3281664A1
公开(公告)日：2018-02-14
申请号：EP17190469.1
申请日：2013-02-25
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , LECLERC, Michael , MAHMOUD, Ramy A , SIWINSKI, Shane , GORDON, Joseph , FISK, Justin
摘要： A nasal delivery device for delivering substance to a nasal airway of a subject, comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit (120), which comprises an actuation part (173) which is manually displaceable to actuate the delivery unit (120) to deliver substance from the nosepiece (119); and a valve assembly (127) which is fluidly connected to the nosepiece (117) and the mouthpiece (119), wherein the valve assembly (127) comprises a body element (128) and a valve element (131) which is movably disposed to the body element (128) between closed and open configurations by manual displacement of the actuation part (173) of the delivery unit (120) to provide for an air flow through the nosepiece (117) simultaneously with delivery of substance; characterized in that the valve assembly (127), on opening of the valve element (131), provides for a burst of air flow, having a first, initial burst phase followed by a second, extended burst phase, wherein the peak flow rate in the first burst phase is at least 10% greater than that of the average flow rate of the second burst phase in a period corresponding to ten times the duration of the period in which substance is delivered from the delivery unit (120).
摘要翻译： 1.一种用于将物质递送到受试者的鼻气道的鼻递送装置，包括：用于装配到受试者的鼻腔的鼻形件（117） 吹嘴（119），使用中的对象正在呼气; 包括可手动移位以致动所述输送单元（120）以从所述喷嘴（119）输送物质的致动部分（173）的输送单元（120）; 以及流体连接到所述喷嘴（117）和所述吹口（119）的阀组件（127），其中所述阀组件（127）包括主体元件（128）和阀元件（131），所述阀元件可移动地布置成 通过手动移动输送单元（120）的致动部分（173）在关闭和打开配置之间的主体元件（128），以在输送物质的同时提供通过喷嘴（117）的气流; 其特征在于，所述阀组件（127）在打开所述阀元件（131）时提供气流爆发，所述气流爆发具有第一初始爆发阶段，接着是第二爆发扩展阶段，其中所述峰值流量在 所述第一突发阶段比在与从所述递送单元（120）递送物质的时段的持续时间的十倍相对应的时段中的所述第二突发阶段的平均流率的时段大至少10％。
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公开(公告)号：EP2817054A1
公开(公告)日：2014-12-31
申请号：EP13715145.2
申请日：2013-02-25
申请人： Optinose AS
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M15/0021 , A61M15/0098 , A61M2202/064 , A61M2205/0216 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device for delivering substance to a nasal cavity of a subject comprises: a housing (15); a nosepiece (17) for fitting to a nasal cavity of the subject; a mouthpiece (19) through which the subject in use exhales; and a flexible coupling (20) which couples the mouthpiece to the housing, wherein the flexible coupling provides for asymmetric translation of the mouthpiece relative to the nosepiece.
摘要翻译： 一种用于将物质递送到受试者的鼻腔的鼻腔输送装置，包括：壳体（15）;壳体 鼻子（17），用于装配到对象的鼻腔; 吸嘴（19），使用中的对象呼出; 和将所述咬嘴连接到所述壳体的挠性联接器（20），其中所述挠性联接器提供所述咬嘴相对于所述鼻形件的不对称平移。
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公开(公告)号：EP2817052A1
公开(公告)日：2014-12-31
申请号：EP13711300.7
申请日：2013-02-25
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , LECLERC, Michael , MAHMOUD, Ramy A , SIWINSKI, Shane , GORDON, Joseph , FISK, Justin
CPC分类号： A61M15/08 , A61M15/0018 , A61M15/002 , A61M15/0021 , A61M15/009 , A61M15/0098 , A61M2210/0618
摘要： A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.
摘要翻译： 一种用于将物质输送到受试者的鼻气道的鼻输送装置和方法，所述输送装置包括：鼻梁（117），用于装配到受试者的鼻腔; 使用者呼气的受试者（119）; 输送单元，其包括可手动地移动以致动输送单元以从物镜输送物质的致动部件; 以及阀组件（127），其流体地连接到喷嘴和喷嘴，其中所述阀组件包括主体元件（128）和阀元件（131），所述主体元件（128）和阀元件（131）通过以下方式可移动地设置在所述主体元件 输送单元的致动部分的手动位移以提供与物质输送同时通过喷嘴的气流。
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公开(公告)号：EP3799909A1
公开(公告)日：2021-04-07
申请号：EP20207667.5
申请日：2013-02-25
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , LECLERC, Michael , MAHMOUD, Ramy A , SIWINSKI, Shane , GORDON, Joseph , FISK, Justin
摘要： A nasal delivery device for and method of delivering substance to a nasal airway of a subject, the delivery device comprising: a nosepiece (117) for fitting to a nasal cavity of a subject; a mouthpiece (119) into which the subject in use exhales; a delivery unit, which comprises an actuation part which is manually displaceable to actuate the delivery unit to deliver substance from the nosepiece; and a valve assembly (127) which is fluidly connected to the nosepiece and the mouthpiece, wherein the valve assembly comprises a body element (128) and a valve element (131) which is movably disposed to the body element between closed and open configurations by manual displacement of the actuation part of the delivery unit to provide for an air flow through the nosepiece simultaneously with delivery of substance.
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公开(公告)号：EP2817053B1
公开(公告)日：2018-05-30
申请号：EP13711301.5
申请日：2013-02-25
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , DUDGEON, Kate , GORDON, Joseph , GUARRAIA, Mark , LECLERC, Michael , MAHMOUD, Ramy A
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M15/0021 , A61M2202/04 , A61M2202/064 , A61M2205/586 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.
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公开(公告)号：EP2817052B1
公开(公告)日：2017-09-13
申请号：EP13711300.7
申请日：2013-02-25
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , LECLERC, Michael , MAHMOUD, Ramy A , SIWINSKI, Shane , GORDON, Joseph , FISK, Justin
CPC分类号： A61M15/08 , A61M15/0018 , A61M15/002 , A61M15/0021 , A61M15/009 , A61M15/0098 , A61M2210/0618
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公开(公告)号：EP2817053A1
公开(公告)日：2014-12-31
申请号：EP13711301.5
申请日：2013-02-25
申请人： Optinose AS
发明人： DJUPESLAND, Per Gisle , DUDGEON, Kate , GORDON, Joseph , GUARRAIA, Mark , LECLERC, Michael , MAHMOUD, Ramy A
IPC分类号： A61M15/08
CPC分类号： A61M15/08 , A61M15/0021 , A61M2202/04 , A61M2202/064 , A61M2205/586 , A61M2210/0618 , A61M2210/0625
摘要： A nasal delivery device comprising: a housing (15); a nosepiece (17) for fitting to a nasal cavity of a subject; a mouthpiece (19) through which the subject in use exhales; and a substance supply unit (21) including an actuation member (23) which extends from one end of the housing and is manually actuated to deliver substance to the nasal cavity of the subject; wherein the housing includes a grip section (27) which is disposed at the one end of the housing from which the actuation member extends, said grip section comprising a first, distal part (28) including at least one projecting grip element (29) by which the subject grips the housing in actuating the actuation member, and a second, proximal part (31) providing a recess (33) in which fingers of the subject are located, said recess promoting proper orientation of the delivery device in a hand of the subject.
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