公开(公告)号：EP2046802A2

公开(公告)日：2009-04-15

申请号：EP07804590.3

申请日：2007-07-11

申请人： Orchid Chemicals and Pharmaceuticals Ltd

发明人： UDAYAMPALAYAM, Palanisamy, Senthilkumar ,  GNANAPRAKASAM, Andrew ,  GANAPATHY, Panchapakesan ,  MUKUT, Gohain ,  VENKATASUBRAMANIAN, Hariharan ,  SRIRAM, Rajagopal ,  PAUL-SATYASEELA, Maneesh ,  SOLANKI, Shakti, Singh ,  DEVARAJAN, Sathishkumar

IPC分类号： C07D499/87 ,  C07D499/21 ,  C07D499/28 ,  C07D499/32

CPC分类号： C07D499/86 ,  Y02P20/55

摘要： Novel 2-substituted methyl penam derivatives include the formula (I), their analogs, their tautomeric forms, their stereoisomers, their polymorphs, their solvates, their pharmaceutically acceptable salts, and pharmaceutical compositions containing them; wherein A = C or N; Het is a three- to seven-membered heterocyclic ring; R1 represents carboxylate anion, or -COOR4 where R4 represents hydrogen, carboxylic acid protecting group or a pharmaceutically acceptable salt; R2 and R3 may be same or different and independently represent hydrogen, halogen, amino, alkyl, protected amino, optionally substituted alkyl, alkenyl, alkynyl and the like; R represents substituted or unsubstituted alkyl, alkenyl, aryl, aralkyl, cycloalkyl, heterocyclyl or heterocyclylalkyl.