公开(公告)号：EP4194558A1

公开(公告)日：2023-06-14

申请号：EP22209713.1

申请日：2015-07-16

申请人： Oregon Health & Science University

发明人： FRUEH, Klaus ,  HANSEN, Scott G. ,  NELSON, Jay ,  PICKER, Louis ,  CAPOSIO, Patrizia

IPC分类号： C12N15/86 ,  A61K39/00 ,  A61P31/18

摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

公开(公告)号：EP3169787A1

公开(公告)日：2017-05-24

申请号：EP15745663.3

申请日：2015-07-16

申请人： Oregon Health & Science University

发明人： FRUEH, Klaus ,  HANSEN, Scott G. ,  NELSON, Jay ,  PICKER, Louis ,  CAPOSIO, Patrizia

IPC分类号： C12N15/86 ,  A61K39/00 ,  C07K14/16

CPC分类号： C12N15/86 ,  A61K39/12 ,  A61K39/21 ,  A61K2039/5254 ,  A61K2039/5256 ,  A61K2039/572 ,  C07K14/161 ,  C12N2710/16143 ,  C12N2740/15034 ,  C12N2740/16234

摘要： Human cytomegalovirus vectors comprising heterologous antigens are disclosed. The vectors derived from the TR strain, are ganciclovir-sensitive, include active US2, US3, US6, US7 and UL131A genes, and have a deleterious or inactivating mutation in the UL82 gene preventing the expression of pp71.

摘要翻译： 公开了包含异源抗原的人巨细胞病毒载体。 衍生自TR菌株的载体是更昔洛韦敏感性的，包括活性US2，US3，US6，US7和UL131A基因，并且在UL82基因中具有阻止pp71表达的有害或失活突变。