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1.发明公开Pharmaceutical use of compounds which bind to a mammalian trace amine receptor 审中-公开药物用途的化合物的结合哺乳动物的“痕量胺”受体
公开(公告)号：EP1568770A3
公开(公告)日：2005-11-30
申请号：EP04030304.2
申请日：2001-09-12
发明人： Bunzow, James R. , Grandy, David K.
IPC分类号： C12N15/12 , C07K14/705 , C12Q1/68 , G01N33/566 , A61K31/13 , A61P25/18 , A61P25/24 , A61P25/30 , A61P9/12 , A61P11/06 , A61P29/00
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
摘要翻译： 本发明涉及新的哺乳动物生物胺受体蛋白和基因确实编码的蛋白质检测。 本发明提供了在体外筛选化合物的方法做了能够结合到哺乳动物痕量胺发明受体蛋白，以及它们的与已知的痕量胺受体激动剂和拮抗剂的比较进一步表征测试的化合物和功能后果的结合特性。 由此提供改善的药理学筛选方法。
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">2.发明公开Pharmaceutical use of compounds which bind to a mammalian "trace amine" receptor 审中-公开与哺乳动物“痕量胺”受体结合的化合物的药物用途
公开(公告)号：EP1568770A2
公开(公告)日：2005-08-31
申请号：EP04030304.2
申请日：2001-09-12
发明人： Bunzow, James R. , Grandy, David K.
IPC分类号： C12N15/12 , C07K14/705 , C12Q1/68 , G01N33/566 , A61K31/13 , A61P25/18 , A61P25/24 , A61P25/30 , A61P9/12 , A61P11/06 , A61P29/00
CPC分类号： C07K14/70571 , A61K38/00
摘要： The present invention relates to novel mammalian biogenic amine receptor proteins and genes that encode such proteins. The invention provides methods for screening compounds in vitro that are capable of binding to the mammalian trace amine receptor proteins of the invention, and further characterizing the binding properties of such compounds and functional consequences thereof in comparison with known trace amine receptor agonists and antagonists. Improved methods of pharmacological screening are provided thereby.
摘要翻译： 本发明涉及新的哺乳动物生物胺受体蛋白质和编码这种蛋白质的基因。 本发明提供了用于体外筛选能够结合本发明的哺乳动物微量胺受体蛋白的化合物的方法，并进一步表征了这些化合物的结合特性及其与已知的痕量胺受体激动剂和拮抗剂相比的功能结果。 由此提供了改进的药理筛选方法。
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