公开(公告)号：EP3394261A1

公开(公告)日：2018-10-31

申请号：EP16880104.1

申请日：2016-12-22

申请人： Oregon State University ,  Board of Regents, The University of Texas System

发明人： GREENBERG, David ,  GELLER, Bruce L. ,  TOPRAK, Erdal

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  C12N2310/11 ,  C12N2310/3233

摘要： Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or essential genes, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject.

公开(公告)号：EP3394262A1

公开(公告)日：2018-10-31

申请号：EP16880107.4

申请日：2016-12-22

申请人： Oregon State University ,  Board of Regents, The University of Texas System

发明人： GREENBERG, David ,  GELLER, Bruce L.

IPC分类号： C12N15/113

CPC分类号： C12N15/113 ,  A61K31/7115 ,  A61K31/712 ,  A61K47/42 ,  A61K47/66 ,  C12N2310/11 ,  C12N2310/3233

摘要： Provided are antisense oligomers targeted against bacterial mRNAs and other macromolecules associated with a biochemical pathway and/or cellular process, and related compositions and methods of using the oligomers and compositions to treat an infected mammalian subject, for example, as primary antimicrobials or as adjunctive therapies with classic antimicrobials.

公开(公告)号：EP3143141B1

公开(公告)日：2019-10-02

申请号：EP15792493.7

申请日：2015-05-15

申请人： Oregon State University ,  BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

发明人： GELLER, Bruce L. ,  GREENBERG, David

IPC分类号： A61K47/64 ,  C12N15/11 ,  C12N15/00 ,  A61K38/08 ,  C12N15/113

公开(公告)号：EP3143141A2

公开(公告)日：2017-03-22

申请号：EP15792493.7

申请日：2015-05-15

申请人： Oregon State University ,  BOARD OF REGENTS THE UNIVERSITY OF TEXAS SYSTEM

发明人： GELLER, Bruce L. ,  GREENBERG, David

IPC分类号： C12N15/11 ,  C12N15/00 ,  A61K38/08

CPC分类号： C12N15/113 ,  A61K38/00 ,  A61K47/64 ,  A61K47/6455 ,  C12N2310/11 ,  C12N2310/3233 ,  C12N2310/3513 ,  C12N2320/50 ,  Y02A50/473

摘要： Provided are antisense morpholino oligomers targeted against bacterial virulence factors such as genes that contribute to antibiotic resistance or biofilm formation, or genes associated with fatty acid biosynthesis, and related compositions and methods of using the oligomers and compositions, for instance, in the treatment of an infected mammalian subject.

摘要翻译： 提供了针对细菌毒力因子的反义吗啉代低聚物，例如有助于抗生素抗性或生物膜形成的基因，或与脂肪酸生物合成相关的基因，以及使用寡聚物和组合物的相关组合物和方法，例如用于治疗 感染哺乳动物受试者。