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公开(公告)号：EP3865570A1
公开(公告)日：2021-08-18
申请号：EP19867367.5
申请日：2019-09-19
发明人： TSUJI, Takashi , ASAKAWA, Kyosuke , TAKEO, Makoto , TOYOSHIMA, Koh-ei , OGAWA, Miho , MORI, Yutaka , KISHIMOTO, Kyosuke
摘要： [PROBLEM] To provide means for efficient growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs.
[SOLUTION MEANS] Provided are a culture medium for growth of epithelial cells capable of being used to manufacture regenerated hair follicle germs, the culture medium comprising basal medium and at least (1) through (3) below; and a method for growing the epithelial cells using the culture medium: (1) at least one species of BMP inhibitor; (2) at least one species of fibroblast growth factor; and (3) at least one species of sonic hedgehog (SHH) and/or SHH agonist.-
公开(公告)号：EP3805368A1
公开(公告)日：2021-04-14
申请号：EP19814103.8
申请日：2019-05-31
发明人： TSUJI, Takashi , MORI, Yutaka , TOYOSHIMA, Koh-ei
IPC分类号： C12N5/071 , A61K35/28 , A61K35/36 , A61L27/04 , A61L27/08 , A61L27/10 , A61L27/14 , A61L27/36 , A61L27/38 , A61L27/40 , A61L27/58 , A61P17/14 , C12N5/077
摘要： The present invention provides a method for producing regenerated hair follicle primordium that allows production of regenerated hair follicle primordium more easily and in larger amounts compared to conventional production methods. A method for producing regenerated hair follicle primordium comprising a step of obtaining hair follicle primordium by culturing a first population of cells comprising epithelial cells and a second population of cells comprising mesenchymal cells while allowing them to be in contact is provided. The production method of the present invention is characterized in that at least either one of said first population of cells and said second population of cells has formed cell aggregates before said contact, and a culture support is not used when contacting the other population of cells with said cell aggregate.
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