公开(公告)号：EP4293117A1

公开(公告)日：2023-12-20

申请号：EP21925597.3

申请日：2021-02-10

申请人： Oriental Yeast Co., Ltd.

发明人： ICHIMARU, Kenta ,  MATSUKAWA, Hirokazu ,  MIYACHI, Mayu ,  TAKETANI, Yukiko ,  IKENO, Chizuka ,  SUNAHARA, Yoshiko

IPC分类号： C12N15/55 ,  C12Q1/26 ,  C12Q1/34 ,  C12N9/06 ,  C12N9/14 ,  G01N33/50

摘要： Provided are a uricase activator and a uricase activation method which are capable of highly activating uricase. Also provided are a uric acid measurement reagent and a uric acid measurement method which have a wide measurable concentration range. Further provided are a uricase activator comprising hydroxyisourate hydrolase, and a uric acid measurement reagent for use in measuring a uric acid concentration in a sample collected from a living body, comprising uricase and hydroxyisourate.

公开(公告)号：EP2554658A1

公开(公告)日：2013-02-06

申请号：EP11765760.1

申请日：2011-03-31

申请人： Oriental Yeast Co., Ltd.

发明人： YASUDA, Hisataka ,  YAMADA, Munehiro ,  TAKETANI, Yukiko ,  TOMIMORI, Yoshiya ,  MORI, Kaoru

IPC分类号： C12N5/07 ,  C12N5/0735 ,  C12N5/0775 ,  C12N5/0786 ,  C12N5/0789 ,  C12N5/0797 ,  C07K14/525 ,  C07K14/765 ,  C07K14/78 ,  C07K14/79

CPC分类号： C07K14/78 ,  C12N5/0068 ,  C12N2533/52

摘要： The present invention is directed to providing a method for culturing cells in a system containing laminin-5. The method of the present invention is characterized by a culture system containing a polypeptide selected from a group consisting of: a protein in blood other than extracellular matrix proteins, which is, serum, serum albumin, prealbumin, immunoglobulin, α-globulin, β-globulin, α1-antitrypsin (α1-AT), heptoglobin (Hp), α2-macroglobulin (α2-M), α-fetoprotein (AFP), transferrin, retinol-binding protein (RBP) or adiponectin; gelatin; a protein belonging to a tumor necrosis factor (TNF) family; and peptone.

摘要翻译： 本发明旨在提供一种在含有层粘连蛋白-5的系统中培养细胞的方法。 本发明的方法的特征在于包含选自以下的多肽的培养系统：除了细胞外基质蛋白之外的血液中的蛋白质，即血清，血清白蛋白，前白蛋白，免疫球蛋白，± - 球蛋白， 球蛋白，±1-抗胰蛋白酶（±1-AT），肝球蛋白（Hp），±2-巨球蛋白（±2-M），±甲胎蛋白（AFP），转铁蛋白，视黄醇结合蛋白（RBP）或脂联素; 明胶; 属于肿瘤坏死因子（TNF）家族的蛋白质; 和蛋白胨。