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公开(公告)号：EP3423440A1
公开(公告)日：2019-01-09
申请号：EP17711366.9
申请日：2017-03-02
发明人： KATOH, Takahiro , IIDA, Masatoshi , TERAUCHI, Yuki , YAMAGUCHI, Kazuya , HIROSE, Toshiyuki , YOKOYAMA, Fumiharu , NISHIMORI, Hikaru , OBUCHI, Yutaka , NABESHIMA, Hiroshi , TAKAKI, Emiri
IPC分类号： C07D237/02 , C07D237/14 , A61K31/50 , A61P35/00
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公开(公告)号：EP2528897B1
公开(公告)日：2014-10-15
申请号：EP11705048.4
申请日：2011-01-28
发明人： TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
IPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61P35/00
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
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公开(公告)号：EP2528897A1
公开(公告)日：2012-12-05
申请号：EP11705048.4
申请日：2011-01-28
发明人： TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
IPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61P35/00
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].
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公开(公告)号：EP2528897B9
公开(公告)日：2015-09-09
申请号：EP11705048.4
申请日：2011-01-28
发明人： TAKASU, Hideki , FUJITA, Shigekazu , OHTSUKA, Shinya , HIROSE, Toshiyuki , SATO, Yosuke , YAMADA, Satoshi , MIYAJIMA, Keisuke , SAKAI, Koji , KOJIMA, Yutaka , SEKIGUCHI, Kazuo , YANAGIHARA, Yasuo , SUZUKI, Takashi , TANAKA, Hideo , SUGIYAMA, Kazuhisa , OKUNO, Mitsuhiro , SUMIDA, Takumi
IPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/4725 , A61K31/443 , A61K31/496 , A61P35/00
CPC分类号： C07D213/69 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12
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