公开(公告)号：EP2528897B9

公开(公告)日：2015-09-09

申请号：EP11705048.4

申请日：2011-01-28

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： TAKASU, Hideki ,  FUJITA, Shigekazu ,  OHTSUKA, Shinya ,  HIROSE, Toshiyuki ,  SATO, Yosuke ,  YAMADA, Satoshi ,  MIYAJIMA, Keisuke ,  SAKAI, Koji ,  KOJIMA, Yutaka ,  SEKIGUCHI, Kazuo ,  YANAGIHARA, Yasuo ,  SUZUKI, Takashi ,  TANAKA, Hideo ,  SUGIYAMA, Kazuhisa ,  OKUNO, Mitsuhiro ,  SUMIDA, Takumi

IPC分类号： C07D213/69 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/443 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D213/69 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：EP2528897B1

公开(公告)日：2014-10-15

申请号：EP11705048.4

申请日：2011-01-28

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： TAKASU, Hideki ,  FUJITA, Shigekazu ,  OHTSUKA, Shinya ,  HIROSE, Toshiyuki ,  SATO, Yosuke ,  YAMADA, Satoshi ,  MIYAJIMA, Keisuke ,  SAKAI, Koji ,  KOJIMA, Yutaka ,  SEKIGUCHI, Kazuo ,  YANAGIHARA, Yasuo ,  SUZUKI, Takashi ,  TANAKA, Hideo ,  SUGIYAMA, Kazuhisa ,  OKUNO, Mitsuhiro ,  SUMIDA, Takumi

IPC分类号： C07D213/69 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/443 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D213/69 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

公开(公告)号：EP2528897A1

公开(公告)日：2012-12-05

申请号：EP11705048.4

申请日：2011-01-28

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： TAKASU, Hideki ,  FUJITA, Shigekazu ,  OHTSUKA, Shinya ,  HIROSE, Toshiyuki ,  SATO, Yosuke ,  YAMADA, Satoshi ,  MIYAJIMA, Keisuke ,  SAKAI, Koji ,  KOJIMA, Yutaka ,  SEKIGUCHI, Kazuo ,  YANAGIHARA, Yasuo ,  SUZUKI, Takashi ,  TANAKA, Hideo ,  SUGIYAMA, Kazuhisa ,  OKUNO, Mitsuhiro ,  SUMIDA, Takumi

IPC分类号： C07D213/69 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12 ,  A61K31/44 ,  A61K31/4439 ,  A61K31/4545 ,  A61K31/4725 ,  A61K31/443 ,  A61K31/496 ,  A61P35/00

CPC分类号： C07D213/69 ,  C07D401/12 ,  C07D405/12 ,  C07D413/12 ,  C07D417/12

摘要： The present invention provides a novel compound having an excellent antitumor effect. The compound of the present invention is represented by the following general formula (1) wherein R1 and R2 are aryl or the like; A is lower alkylene; Ring X is optionally substituted arylene; E is bond or lower alkenylene; Ring Y is optionally substituted heterocycloalkylene containing one or more nitrogen atoms, one of which is attached to the adjacent carbonyl group; G is —NH-G2-, —N(lower alkyl)-G2-, —NH—CH2-G2-, —N(lower alkyl)-CH2-G2- or —CH2-G2-, [wherein G2 binds to R2, G2-R2 is bond-R2, phenylene-G3-R2, phenylene-G4-O—R2, phenylene-G5-NH—R2, phenylene-G6-N(lower alkyl)-R2 or quinolinediyl-O—R2, the phenylene of said phenylene-containing groups being optionally substituted with one or more substituents; G3-R2 is —O-lower alkylene-R2 or the like; G4-O— is lower alkylene-O— or the like; G5 is lower alkylene; G6 is lower alkylene].