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    PREPARATIONS FOR DIAGNOSING INFECTION WITH HELICOBACTER PYLORI
    1.
    发明公开
    PREPARATIONS FOR DIAGNOSING INFECTION WITH HELICOBACTER PYLORI 无效
    ZUSAMMENSETZUNGENFÜRDIE DIAGNOSE VON HELICOBACTER PYLORI INFEKTIONEN

    公开(公告)号：EP1283060A1

    公开(公告)日：2003-02-12

    申请号：EP01930187.8

    申请日：2001-05-17

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： TSUCHIYA, Kyoko ,  OKAMURA, Akio, ,  KAWASAKI, Junichi ,  UNO, Shinichiro, ,  NODA, Atsunari ,  NISHIWAKI, Satoshi

    IPC分类号： A61K51/04 ,  A61K9/30 ,  A61K47/02 ,  A61K47/10 ,  A61K47/14 ,  A61K47/26 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

    CPC分类号： A61K51/1206 ,  A61K49/1815

    摘要： A coated preparation for the detection of a H . pylori infection according to a urea breath test protocol which comprises a core composition containing at least an isotope C-labeled urea, an exoipient and a lubricant in defined proportions and covered with 0.1-10 parts by weight of a coating agent based on 100 parts by weight of the core composition. With this preparation, the influence of the urease-producing bacteria resident in organs other than the stomach, such as the mouth and throat, is excluded to enable a diagnosis of H . pylori infection without the risk for a false-positive test and with reasonable rapidity.

    摘要翻译： 一种用于根据尿素呼吸测试方案检测幽门螺杆菌感染的包衣制剂，其包含至少含有同位素C-标记的尿素，外用剂和润滑剂，并以0.1-10份 基于100重量份的芯组合物涂布剂的重量。 通过该制备，除了胃和胃部以外的器官中，例如口腔和咽喉的尿素酶生产细菌的影响被排除，以便能够诊断幽门螺杆菌感染而没有假阳性检验的风险，并且具有合理的 快速性。

    TABLETS HAVING IMPROVED TABLETTING CHARACTERISTICS AND PROCESS FOR PRODUCING THE SAME
    4.
    发明公开
    TABLETS HAVING IMPROVED TABLETTING CHARACTERISTICS AND PROCESS FOR PRODUCING THE SAME 审中-公开
    维他命MU VERBESSERTEN TABLETTIERUNGSEIGENSCHAFTEN UND VERFAHREN ZU IHRER HERSTELLUNG

    公开(公告)号：EP1475084A1

    公开(公告)日：2004-11-10

    申请号：EP03705117.4

    申请日：2003-02-13

    申请人： OTSUKA PHARMACEUTICAL CO., LTD.

    发明人： KAWASAKI, Junichi

    IPC分类号： A61K9/20 ,  A61K47/32 ,  A61K47/36 ,  A61K47/38

    CPC分类号： A61K9/2059 ,  A61K9/2018 ,  A61K9/2054

    摘要： It is intended to provide tablets which have a favorable texture in taking and excellent compressing characteristics, friability and mechanical strength. Tablets which are produced by blending a powdery or granular mixture comprising (1) an effective amount of a pharmacologically active substance and (2) 50% by weight or more of a water-soluble filler based on the powdery or granular mixture with (3) a compressing characteristic improving agent containing moisture at least in an amount corresponding to the equilibrated moisture content at 25°C under a humidity of 12% and having an average particle size of 100 µm or less, at a ratio of from 1 to 50% by weight based on the above mixture, and then compressing the resultant mixture.

    摘要翻译： 旨在提供具有良好的织构和优异的压缩特性，脆性和机械强度的片剂。 通过混合粉末或颗粒混合物制备的片剂，其包含（1）有效量的药理活性物质和（2）基于粉末或颗粒混合物的50重量％或更多的水溶性填料与（3） 压缩特性提高剂，其含有至少相当于25℃，12％湿度和平均粒径为100μm以下的平衡水分含量的水分，其比例为1〜50％ ，然后压制所得混合物。