公开(公告)号：EP2821415A1

公开(公告)日：2015-01-07

申请号：EP13755814.4

申请日：2013-02-28

申请人： Otsuka Pharmaceutical Co., Ltd.

发明人： KATSURAGI, Kiyonori ,  TOGASHI, Masataka ,  ODA, Tetsuya ,  ITO, Ryuta ,  KAWAGUCHI, Chie ,  SAIJO, Yoko ,  KOGA, Daisuke ,  MATSUMOTO, Makoto ,  FUJIWARA, Mamoru ,  ONO, Kenji

IPC分类号： C07K16/12 ,  C12M1/34 ,  C12N15/02 ,  C12N15/09 ,  C12P21/08 ,  C12Q1/02 ,  G01N33/53 ,  G01N33/543 ,  G01N33/569 ,  G01N33/577

CPC分类号： C07K16/1285 ,  C07K16/005 ,  C07K16/1289 ,  C07K2317/35 ,  C07K2317/622 ,  G01N33/5695 ,  G01N2333/35 ,  G01N2400/50

摘要： The present invention provides a monoclonal antibody that specifically binds to acid-fast bacillary lipoarabinomannan, particularly tubercle bacillary lipoarabinomannan, the antibody being set forth below:
(A) a monoclonal antibody comprising a heavy chain variable region and a light chain variable region joined via a linker, the heavy chain variable region comprising heavy chains CDR1 to CDR3 shown in (a) to (c) below, and the light chain variable region comprising light chains CDR1 to CDR3 shown in (d) to (f) below:
(a) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 1,
(b) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 2,
(c) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 3,
(d) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 4,
(e) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 5, and
(f) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 6.


The present invention further provides the use of the antibody.

摘要翻译： 本发明提供的单克隆抗体没有特异性结合抗酸杆菌脂阿拉伯甘露聚糖，特别是结节杆菌脂阿拉伯甘露聚糖，被下面阐述的抗体：（A）一种单克隆抗体，其包含重链可变区和轻链可变区通过连接 左，在（a）至（c）中所示的重链可变区，其包含重链CDR1至CDR3，和在（d）所示的轻链可变区，其包含轻链CDR1至CDR3至（f）如下：（a） 重链CDR1由SEQ ID NO列出的氨基酸序列：1，（b）重链CDR1由SEQ ID NO列出的氨基酸序列组成：2，（C）重链CDR1由氨基酸的 序列在SEQ ID NO：3所示，（d）中的轻链CDR1由SEQ ID NO列出的氨基酸序列组成：（E）轻链CDR1由SEQ ID NO列出的氨基酸序列的4： 5，和（f）轻链CDR1的由...组成的AMI 没有酸序列在SEQ ID NO阐述：6.本发明还提供了使用该抗体。