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1.发明授权BACULOVIRAL VECTORS WITH A DUAL VERTEBRATE AND BACULOVIRUS PROMOTER CONTROLLING AN IMMUNOGENIC FUSION GENE. 有权WITH A杆状病毒载体监测的免疫原性融合脊椎动物和杆状病毒双启动子
公开(公告)号：EP2191002B1
公开(公告)日：2016-04-13
申请号：EP08792433.8
申请日：2008-08-06
发明人： YOSHIDA, Shigeto , KAWASAKI, Masanori , MATSUMOTO, Makoto , OHBA, Yoshio , SAITO, Masahiro , GOTO, Yoshihiro , INAGAKI, Katsuya , MIZUKOSHI, Masami , HARIGUCHI, Norimitsu , HIROTA, Kuniko
IPC分类号： C12N15/866 , A61K39/145 , A61K39/015
CPC分类号： C07K16/1018 , A61K39/015 , A61K39/12 , A61K39/145 , A61K2039/5256 , C07K14/005 , C07K14/445 , C07K16/205 , C07K2319/735 , C12N7/00 , C12N15/86 , C12N2710/14122 , C12N2710/14143 , C12N2760/16122 , C12N2760/16134 , C12N2830/15 , C12N2830/60 , C12N2830/85 , Y02A50/412
摘要： The present invention provides a novel transfer vector and a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient, which are useful as preventive or therapeutic drugs for infectious diseases such as malaria and influenza. More specifically, the invention provides a recombinant transfer vector capable of expressing a foreign gene fused to a virus gene under the control of a dual promoter; a recombinant baculovirus; methods for the production thereof; and pharmaceuticals containing the recombinant baculovirus as an active ingredient.
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公开(公告)号：EP1555267A1
公开(公告)日：2005-07-20
申请号：EP03754085.3
申请日：2003-10-10
发明人： TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi , KURODA, Hideaki , ITOTANI, Motohiro , HASEGAWA, Takeshi; Daiichiaijitsuhaitsu 607, , HARAGUCHI, Yoshikazu , KURODA, Takeshi , MATSUZAKI, Takayuki , TAI, Kuninori , KOMATSU, Makoto , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki; Daiaparesu 1401, , TOMISHIGE, Tatsuo , SEIKE, Yuji , KAWASAKI, Masanori , SUMIDA, Takumi , MIYAMURA, Shin; 147-13, Mukaininokoshi,
IPC分类号： C07D498/04 , C07D498/20 , C07D519/00 , A61K31/424
CPC分类号： C07D498/04 , C07D498/20 , C07F7/0812
摘要： The present invention provides a 2,3-dihydro-6-nitroimidazo[2,1-b]oxazole compound represented by the following general formula:
wherein R 1 represents a hydrogen atom or C1-C6 alkyl group, n represents an integer of 0 to 6, R 2 represents a group -OR 3 or the like, and R 3 represents a hydrogen atom, C1-C6 alkyl group or the like, or R 1 and -(CH 2 ) n R 2 may bind to each other together with carbon atoms adjacent thereto through nitrogen atoms so as to form a spiro ring represented by the general formula (H):
wherein R 41 is hydrogen, C1-C6 alkyl group or the like. The present compound has an excellent bactericidal action against Mycobacterium tuberculosis, multi-drug-resistant Mycobacterium tuberculosis, and a typical acid-fast bacteria.摘要翻译： 本发明提供由以下通式表示的2,3-二氢-6-硝基咪唑并[1,2-a]恶唑化合物：其中R 1表示氢原子或C 1 -C 6烷基，n表示整数 0至6，R 2代表基团-OR 3等，R 3表示氢原子，C 1 -C 6烷基等，或R 1和 - （CH 2）n R 2可以通过氮原子与与其相邻的碳原子彼此结合，形成由通式（H）表示的螺环：其中R 41是氢，C1-C6烷基或 类似。 本发明化合物对结核分枝杆菌，多药耐药结核分枝杆菌和典型的耐酸细菌具有优异的杀菌作用。
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公开(公告)号：EP3836931A1
公开(公告)日：2021-06-23
申请号：EP19759445.0
申请日：2019-08-09
发明人： SHIBUYA, Isao , OKA, Daisuke , FUJII, Kazuyuki , TAGAKI, Hiroko , SATO, Masayoshi , NAKASHIMA, Takako , MATSUMOTO, Makoto ,
IPC分类号： A61K31/497 , A01N43/90 , A61P1/00 , A61P29/00 , A61P31/04 , C07D471/04
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4.发明公开ANTI-LIPOARABINOMANNAN ANTIBODY AND IMMUNOASSAY FOR MYCOBACTERIOSIS USING SAID ANTIBODY 审中-公开抗体和免疫分析脂阿拉伯甘露聚糖分枝杆菌使用这种抗体
公开(公告)号：EP2821415A1
公开(公告)日：2015-01-07
申请号：EP13755814.4
申请日：2013-02-28
发明人： KATSURAGI, Kiyonori , TOGASHI, Masataka , ODA, Tetsuya , ITO, Ryuta , KAWAGUCHI, Chie , SAIJO, Yoko , KOGA, Daisuke , MATSUMOTO, Makoto , FUJIWARA, Mamoru , ONO, Kenji
IPC分类号： C07K16/12 , C12M1/34 , C12N15/02 , C12N15/09 , C12P21/08 , C12Q1/02 , G01N33/53 , G01N33/543 , G01N33/569 , G01N33/577
CPC分类号： C07K16/1285 , C07K16/005 , C07K16/1289 , C07K2317/35 , C07K2317/622 , G01N33/5695 , G01N2333/35 , G01N2400/50
摘要： The present invention provides a monoclonal antibody that specifically binds to acid-fast bacillary lipoarabinomannan, particularly tubercle bacillary lipoarabinomannan, the antibody being set forth below:
(A) a monoclonal antibody comprising a heavy chain variable region and a light chain variable region joined via a linker, the heavy chain variable region comprising heavy chains CDR1 to CDR3 shown in (a) to (c) below, and the light chain variable region comprising light chains CDR1 to CDR3 shown in (d) to (f) below:
(a) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 1,
(b) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 2,
(c) heavy chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 3,
(d) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 4,
(e) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 5, and
(f) light chain CDR1 consisting of the amino acid sequence set forth in SEQ ID NO: 6.
The present invention further provides the use of the antibody.摘要翻译： 本发明提供的单克隆抗体没有特异性结合抗酸杆菌脂阿拉伯甘露聚糖，特别是结节杆菌脂阿拉伯甘露聚糖，被下面阐述的抗体：（A）一种单克隆抗体，其包含重链可变区和轻链可变区通过连接 左，在（a）至（c）中所示的重链可变区，其包含重链CDR1至CDR3，和在（d）所示的轻链可变区，其包含轻链CDR1至CDR3至（f）如下：（a） 重链CDR1由SEQ ID NO列出的氨基酸序列：1，（b）重链CDR1由SEQ ID NO列出的氨基酸序列组成：2，（C）重链CDR1由氨基酸的 序列在SEQ ID NO：3所示，（d）中的轻链CDR1由SEQ ID NO列出的氨基酸序列组成：（E）轻链CDR1由SEQ ID NO列出的氨基酸序列的4： 5，和（f）轻链CDR1的由...组成的AMI 没有酸序列在SEQ ID NO阐述：6.本发明还提供了使用该抗体。
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公开(公告)号：EP1555267B1
公开(公告)日：2013-01-16
申请号：EP03754085.3
申请日：2003-10-10
发明人： TSUBOUCHI, Hidetsugu , SASAKI, Hirofumi , KURODA, Hideaki , ITOTANI, Motohiro , HASEGAWA, Takeshi; Daiichiaijitsuhaitsu 607, , HARAGUCHI, Yoshikazu , KURODA, Takeshi , MATSUZAKI, Takayuki , TAI, Kuninori , KOMATSU, Makoto , MATSUMOTO, Makoto , HASHIZUME, Hiroyuki; Daiaparesu 1401, , TOMISHIGE, Tatsuo , SEIKE, Yuji , KAWASAKI, Masanori , SUMIDA, Takumi , MIYAMURA, Shin; 147-13, Mukaininokoshi,
IPC分类号： C07D498/04 , C07D498/20 , C07D519/00 , A61K31/424 , A61P31/06 , C07F7/08
CPC分类号： C07D498/04 , C07D498/20 , C07F7/0812
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公开(公告)号：EP3186240B1
公开(公告)日：2019-06-12
申请号：EP15763096.3
申请日：2015-08-28
发明人： SHIMIZU, Hiroshi , KAWANO, Yoshikazu , ISHIKAWA, Shunpei , UEMATSU, Yukitaka , SHINOHARA, Toshio , ITOTANI, Motohiro , HARAGUCHI, Yoshikazu , TAKEMURA, Isao , KANESHIGE, Atsunori , NAKAI, Yuya , HARIGUCHI, Norimitsu , HAYASHI, Yohei , MATSUMOTO, Makoto
IPC分类号： C07D401/14 , C07D215/227 , C07D401/06 , A61K31/4709 , A61P31/06
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公开(公告)号：EP3421454A1
公开(公告)日：2019-01-02
申请号：EP17756680.9
申请日：2017-02-27
发明人： KAWANO, Yoshikazu , SHIMIZU, Hiroshi , ISHIKAWA, Shunpei , TAKEMURA, Isao , HARIGUCHI, Norimitsu , MATSUBA, Miki , MATSUMOTO, Makoto
IPC分类号： C07D211/44 , A61K31/4525 , A61K31/454 , A61K31/4545 , A61K31/4709 , A61K31/4725 , A61K31/498 , A61K31/517 , A61K31/536 , A61K31/5415 , A61K31/55 , A61K31/553 , A61K31/554 , A61P31/06 , C07D401/12 , C07D405/12 , C07D411/12 , C07D413/12 , C07D417/12 , C07D471/04
摘要： The purpose of the present invention is to provide a compound having excellent antibacterial activity against mycobacterium tuberculosis, multidrug-resistant tuberculosis bacteria, and/or non-tuberculous acid-fast bacteria. A compound represented by formula [I]:
(in the formula, each symbol is as described in the attached specification), or a salt thereof can be used to diagnose, prevent, and/or treat tuberculosis.-
公开(公告)号：EP2697232B1
公开(公告)日：2016-05-18
申请号：EP12723752.7
申请日：2012-04-13
发明人： KAWANO, Yoshikazu , HARAGUCHI, Yoshikazu , SASAKI, Hirofumi , UEMATSU, Yukitaka , TSUBOUCHI, Hidetsugu , YATA, Hiromi , SHIMIZU, Hiroshi , KOHASHI, Kazuho , ITOTANI, Motohiro , TAI, Kuninori , TAKEMURA, Isao , HAYASHI, Mikayo , HASHIZUME, Hiroyuki , MATSUBA, Miki , NAKAMURA, Izuru , CHEN, Xiuhao , MATSUMOTO, Makoto
IPC分类号： C07D498/04 , A61K31/5365 , A61P31/04 , A61P31/06
CPC分类号： C07D498/04
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公开(公告)号：EP1983047A1
公开(公告)日：2008-10-22
申请号：EP07708219.6
申请日：2007-02-08
发明人： YOSHIDA, Shigeto , OHBA, Yoshio , HARIGUCHI, Norimitsu , MIZUKOSHI, Masami , KAWASAKI, Masanori , MATSUMOTO, Makoto , GOTO, Yoshihiro
CPC分类号： C12N15/86 , A61K39/00 , A61K39/015 , A61K39/04 , A61K39/12 , A61K39/145 , A61K2039/525 , A61K2039/5256 , A61K2039/543 , A61K2039/544 , C07K14/005 , C07K2319/02 , C07K2319/43 , C12N2710/14143 , C12N2760/16134 , C12N2830/205 , Y02A50/386 , Y02A50/394 , Y02A50/41 , Y02A50/412
摘要： A recombinant transfer vector capable of expressing a foreign gene fused to a viral gene under the control of dual promoters and a recombinant baculovirus, and methods for production thereof, as well as pharmaceuticals comprising the recombinant baculovirus as an active ingredient.
摘要翻译： 能够在双重启动子和重组杆状病毒的控制下表达与病毒基因融合的外源基因的重组转移载体及其制备方法，以及包含重组杆状病毒作为活性成分的药物。
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公开(公告)号：EP1931425A1
公开(公告)日：2008-06-18
申请号：EP06811551.8
申请日：2006-10-04
发明人： MATSUMOTO, Makoto , HASHIZUME, Hiroyuki , TOMISHIGE, Tatsuo , KAWASAKI, Masanori , SHIMOKAWA, Yoshihiko
IPC分类号： A61P31/06 , A61K31/424 , A61K31/454 , A61K31/496 , A61K45/06
CPC分类号： A61K31/4965 , A61K31/133 , A61K31/424 , A61K31/427 , A61K31/451 , A61K31/454 , A61K31/495 , A61K31/496 , A61K31/52 , A61K31/536 , A61K45/06 , A61K2300/00
摘要： The present invention provides antituberculous therapeutic drugs with a higher potency. The present invention provides also antituberculous therapeutic drugs containing oxazole compounds represented by (I) general formula (1): [wherein R1 represents a hydrogen atom or C1-6 alkyl group, n represents an integer of 0-6, and R2 represents general formula (A) or the like, wherein R3 represents a phenoxy group (at least one group selected from the group consisting of a halogen atom, an optionally halogen-substituted C1-6 alkyl group and an optionally halogen-substituted C1-6 alkoxy group may be substituted on the phenyl ring) or the like], optically active forms thereof or salts thereof, and drugs (II) such as primary antituberculous drugs.
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