公开(公告)号：EP3057975B1

公开(公告)日：2019-09-04

申请号：EP14787034.9

申请日：2014-10-15

申请人： Oxford University Innovation Limited ,  Glycovaxyn AG

发明人： DAVIS, Benjamin G. ,  VIJAYAKRISHNAN, Balakumar ,  LUI, Feng ,  WACKER, Michael ,  FARIDMOAYER, Amirreza ,  KOWARIK, Michael Thomas

IPC分类号： C07H11/04 ,  C07K9/00 ,  C12P19/18

公开(公告)号：EP3057975A1

公开(公告)日：2016-08-24

申请号：EP14787034.9

申请日：2014-10-15

申请人： Oxford University Innovation Limited ,  Glycovaxyn AG

发明人： DAVIS, Benjamin G. ,  VIJAYAKRISHNAN, Balakumar ,  LUI, Feng ,  WACKER, Michael ,  FARIDMOAYER, Amirreza ,  KOWARIK, Michael Thomas

IPC分类号： C07H11/04 ,  C07K9/00 ,  C12P19/18

CPC分类号： C12P19/18 ,  C07H11/04 ,  C07K9/00 ,  C12P19/28

摘要： A process for the production of a glycoconjugate by N-glycosylation of a protein or peptide comprising the sequence D/E-X—N—X—S/T, wherein each X is the same or different and is any natural amino acid other than proline, wherein the process comprises reacting the protein or peptide with a polyisoprenyl pyrophosphate of formula (I), or a salt thereof, in the presence of PglB: (I) to produce the glycoconjugate comprising the protein or peptide having a saccharide [SI] linked to the asparagine in the sequence D/E-X—N—X—S/T. Polyisoprenylpyrophosphates used as substrates in the biocatalytic process are also provided, as well as certain glycoconjugates.

公开(公告)号：EP2747771B1

公开(公告)日：2020-04-01

申请号：EP12753802.3

申请日：2012-08-20

申请人： Oxford University Innovation Limited

发明人： KONG, Lingbing ,  DAVIS, Benjamin G. ,  BAYLEY, Hagan

IPC分类号： A61K31/724 ,  A61P31/04