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公开(公告)号：EP1311699A2
公开(公告)日：2003-05-21
申请号：EP01974582.7
申请日：2001-08-17
IPC分类号： C12N15/864 , C12N15/12 , C07K14/50 , C07K14/52 , C07K14/515 , A61K48/00
CPC分类号： C12N15/86 , A61K38/1825 , A61K38/1866 , A61K38/1891 , A61K48/00 , A61K48/0075 , C07K14/52 , C12N2750/14143
摘要： The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion-delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.
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2.发明公开Adeno-associated virus-mediated delivery of angiogenic factors 审中-公开Durch adenoassoziierte Viren vermittelte Freigabe von Angiogenesefaktoren
公开(公告)号：EP1870473A1
公开(公告)日：2007-12-26
申请号：EP07010881.6
申请日：2001-08-17
IPC分类号： C12N15/864 , C12N15/12 , C07K14/50 , C07K14/52 , C07K14/515 , A61K48/00
CPC分类号： A61K48/00 , A61K48/0075 , C07K14/52 , C12N15/86 , C12N2750/14143
摘要： The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion-delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.
摘要翻译： 公开了使用重组腺相关病毒（rAAV）病毒颗粒将编码血管生成因子的基因递送至肌肉组织。 本发明描述了这种递送方法，并且还描述了治疗缺血状况如心肌缺血的方法。 所述方法包括通过肌内注射直接递送rAAV病毒体到肌肉，并通过注射到向肌肉供血的血管中间接递送至肌肉。 本发明提供rAAV病毒颗粒递送的血管发生因子基因或基因的持续表达，其随后导致可定量的治疗性血管生成因子基因或基因，其随后导致可定量的治疗效果，即增加新的血管形成，导致 血液流向缺血性肌肉组织的增加。
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公开(公告)号：EP1311699B1
公开(公告)日：2007-07-04
申请号：EP01974582.7
申请日：2001-08-17
IPC分类号： C12N15/864 , C12N15/12 , C07K14/50 , C07K14/52 , C07K14/515 , A61K48/00
CPC分类号： C12N15/86 , A61K38/1825 , A61K38/1866 , A61K38/1891 , A61K48/00 , A61K48/0075 , C07K14/52 , C12N2750/14143
摘要： The use of recombinant adeno-associated virus (rAAV) virions for delivery of genes encoding angiogenic factors to muscle tissue is disclosed. The invention describes such methods of delivery and also describes methods for treating an ischemic condition such as myocardial ischemia. The methods include direct delivery of rAAV virions to a muscle via intramuscular injection and indirect delivery to a muscle via an injection into a blood vessel supplying blood to the muscle. The invention provides for sustained expression of the rAAV virion-delivered angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic angiogenic factor gene or genes, which subsequently leads to a quantifiable therapeutic effect, namely an increase in new blood vessel formation resulting in an increase in blood flow to the ischemic muscle tissue.
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