公开(公告)号：EP0909168A2

公开(公告)日：1999-04-21

申请号：EP97922913.0

申请日：1997-04-25

申请人： PARI GmbH Spezialisten für effektive Inhalation

发明人： ZHANG, Zhengfeng ,  KNOCH, Martin

IPC分类号： A61K9 ,  A61K31

CPC分类号： A61K9/008 ,  A61K9/124

摘要： Propellant mixtures and medicament aerosols which contain them are described for micronising medicaments for pulmonary use. The propellant mixture is in a subcritical state and contains at least one component from a first class of propellant gasses and at least one component from a second class of propellant gasses. The first class includes propellant gasses with an evaporation enthalpy of 200 kJ/kg or less at 25 °C and a vapour pressure of 20 bars or more at 25 °C, and the second class includes propellant gasses with an evaporation enthalpy of 300 kJ/kg or more at 25 °C and a vapour pressure of 10 bars or less at 25 °C. By using this propellant mixture in a medicament aerosol, micronised medicaments are obtained in which approximately 80 % by weight of the generated particles have less than 8 νm diameter.

公开(公告)号：EP1119383B1

公开(公告)日：2004-06-23

申请号：EP99942908.7

申请日：1999-08-24

申请人： PARI GmbH Spezialisten für effektive Inhalation

发明人： GALLEM, Thomas ,  STAPLETON, Kevin ,  KNOCH, Martin

IPC分类号： A61M15/00

CPC分类号： A61M15/009 ,  A61M15/0068 ,  A61M15/0075 ,  A61M15/0081 ,  G06M1/041 ,  G06M1/083 ,  G06M1/16

摘要： A metering aerosol dispensing device comprising an aerosol container (23); a nozzle (31, 32) that is arranged in a nozzle body (30), whereby the aerosol is dispensed via said nozzle when the aerosol container (23) is pushed against the body (30) of the nozzle once the metering aerosol dispensing device is actuated; a meter (1, 2, ,4) that counts the number of times that the metering aerosol dispensing device is actuated; and an actuating device (10) that enables the meter (1, 2, 3, 4) to move forward when the metering aerosol dispensing device is actuated. The invention is characterized in that the actuating device (10) is designed and arranged in the metering aerosol dispensing device in such a way that the body (30) of the nozzle is accommodated in the interior of the actuating device (10) and the nozzle (31) is released in order to produce aerosol in an unrestricted manner.

摘要翻译： 一种计量气溶胶分配装置，包括气溶胶容器（23）; 一个布置在喷嘴体（30）中的喷嘴（31,32），其中，当气溶胶容器（23）被推向喷嘴的主体（30）时，通过所述喷嘴分配气溶胶，一旦计量气溶胶分配装置 被启动; 计量所述计量气溶胶分配装置被致动的次数的计量器（1,2,4）;其中， 以及致动装置（10），当所述计量气溶胶分配装置被致动时，所述致动装置能够使所述计量器（1,2,3,4）向前移动。 本发明的特征在于，致动装置（10）被设计和布置在计量气溶胶分配装置中，使得喷嘴的主体（30）容纳在致动装置（10）的内部中，并且喷嘴 （31）被释放以便以不受限制的方式产生气雾剂。

公开(公告)号：EP0909168B1

公开(公告)日：2004-04-21

申请号：EP97922913.5

申请日：1997-04-25

申请人： PARI GmbH Spezialisten für effektive Inhalation

发明人： ZHANG, Zhengfeng ,  KNOCH, Martin

IPC分类号： A61K9/72

CPC分类号： A61K9/008 ,  A61K9/124

摘要： Propellant mixtures and medicament aerosols which contain them are described for micronising medicaments for pulmonary use. The propellant mixture is in a subcritical state and contains at least one component from a first class of propellant gasses and at least one component from a second class of propellant gasses. The first class includes propellant gasses with an evaporation enthalpy of 200 kJ/kg or less at 25 DEG C and a vapour pressure of 20 bars or more at 25 DEG C, and the second class includes propellant gasses with an evaporation enthalpy of 300 kJ/kg or more at 25 DEG C and a vapour pressure of 10 bars or less at 25 DEG C. By using this propellant mixture in a medicament aerosol, micronised medicaments are obtained in which approximately 80 % by weight of the generated particles have less than 8 mu m diameter.

公开(公告)号：EP1119826B1

公开(公告)日：2003-06-18

申请号：EP99946019.9

申请日：1999-08-24

申请人： PARI GmbH Spezialisten für effektive Inhalation

发明人： GALLEM, Thomas ,  STAPLETON, Kevin ,  KNOCH, Martin

IPC分类号： G06M1/04

CPC分类号： A61M15/009 ,  A61M15/0068 ,  A61M15/0075 ,  A61M15/0081 ,  G06M1/041 ,  G06M1/083 ,  G06M1/16

摘要： The present invention relates to a meter, especially a meter for metering aerosol devices, basically consisting of four disk units that are arranged in a parallel position and located on the same axis.