公开(公告)号：EP0734249B1

公开(公告)日：1999-08-11

申请号：EP95937397.8

申请日：1995-10-17

申请人： PATHOGENESIS CORPORATION ,  CHILDREN'S HOSPITAL AND MEDICAL CENTER

发明人： SMITH, Arnold L. ,  RAMSEY, Bonnie W. ,  MONTGOMERY, Alan B.

IPC分类号： A61K9/12 ,  A61K31/73 ,  A61K9/00

CPC分类号： A61K9/0078 ,  A61K31/7036 ,  Y10S514/956

摘要： An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100 % of susceptible bacteria. Aminoglycoside is formulated in 5 ml solution of a quater normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 mu , produced by a jet or ultrasonic nebulizer.

摘要翻译： 用于通过气雾化递送的氨基糖苷制剂。 浓缩的氨基糖苷配方含有有效量的能抑制95-100％敏感细菌的氨基糖苷。 氨基糖苷配制在pH5.5和6.5之间的四分之一生理盐水溶液的5ml溶液中。 通过由喷射或超声雾化器产生的具有主要在1至5μm之间的质量中等平均直径的气溶胶递送的制剂治疗支气管内感染的方法。

公开(公告)号：EP0734249A1

公开(公告)日：1996-10-02

申请号：EP95937397.0

申请日：1995-10-17

申请人： PATHOGENESIS CORPORATION ,  CHILDREN'S HOSPITAL AND MEDICAL CENTER

发明人： SMITH, Arnold L. ,  RAMSEY, Bonnie W. ,  MONTGOMERY, Alan B.

IPC分类号： A61K9 ,  A61K31 ,  A61P31

CPC分类号： A61K9/0078 ,  A61K31/7036 ,  Y10S514/956

摘要： An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100 % of susceptible bacteria. Aminoglycoside is formulated in 5 ml solution of a quater normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 ν, produced by a jet or ultrasonic nebulizer.