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    METHOD FOR THE TREATMENT OF SEVERE CHRONIC BRONCHITIS (BRONCHIECTASIS) WITH AN AEROSOLIZED ANTIBIOTIC
    2.
    发明公开
    METHOD FOR THE TREATMENT OF SEVERE CHRONIC BRONCHITIS (BRONCHIECTASIS) WITH AN AEROSOLIZED ANTIBIOTIC 审中-公开
    严重慢性支气管炎（支气管扩张）的治疗由于抗生素气雾剂

    公开(公告)号：EP1161247A1

    公开(公告)日：2001-12-12

    申请号：EP99967420.3

    申请日：1999-12-17

    申请人： PATHOGENESIS CORPORATION

    发明人： MONTGOMERY, Alan, B. ,  BAKER, William, R.

    IPC分类号： A61K31/70

    CPC分类号： A61K31/7036 ,  A61K9/0073 ,  A61K9/0078

    摘要： A method for treatment of severe chronic bronchitis (bronchiectasis) using a concentrated aminoglycoside antibiotic formulation delivering the antibiotic to the lung endobronchial space including alveoli in an aerosol or dry powder having mass medium diameter predominately between 1 to 5 microns. The method comprises administration of the antibiotic in a concentration one to ten thousand times higher than the minimal inhibitory concentration of the target organism. Preferably, the method comprises endobronchial administration of aerosol or dry powder tobramycin to treat pseudomonal infections in severe chronic bronchitis (bronchiectasis) patients.

    NOVEL AND IMPROVED AMINOGLYCOSIDE FORMULATION FOR AEROSOLIZATION
    3.
    发明授权
    NOVEL AND IMPROVED AMINOGLYCOSIDE FORMULATION FOR AEROSOLIZATION 失效
    NEER UND VERBESSERTE AMINOGLYKOSIDFORMULIERUNG ALS AEROSOL

    公开(公告)号：EP0734249B1

    公开(公告)日：1999-08-11

    申请号：EP95937397.8

    申请日：1995-10-17

    申请人： PATHOGENESIS CORPORATION ,  CHILDREN'S HOSPITAL AND MEDICAL CENTER

    发明人： SMITH, Arnold L. ,  RAMSEY, Bonnie W. ,  MONTGOMERY, Alan B.

    IPC分类号： A61K9/12 ,  A61K31/73 ,  A61K9/00

    CPC分类号： A61K9/0078 ,  A61K31/7036 ,  Y10S514/956

    摘要： An aminoglycoside formulation for delivery by aerosolization. The concentrated aminoglycoside formulation containing an efficacious amount of aminoglycoside able to inhibit 95-100 % of susceptible bacteria. Aminoglycoside is formulated in 5 ml solution of a quater normal saline having pH between 5.5 and 6.5. The method for treatment of endobronchial infections by a formulation delivered as an aerosol having mass medium average diameter predominantly between 1 to 5 mu , produced by a jet or ultrasonic nebulizer.

    摘要翻译： 用于通过气雾化递送的氨基糖苷制剂。 浓缩的氨基糖苷配方含有有效量的能抑制95-100％敏感细菌的氨基糖苷。 氨基糖苷配制在pH5.5和6.5之间的四分之一生理盐水溶液的5ml溶液中。 通过由喷射或超声雾化器产生的具有主要在1至5μm之间的质量中等平均直径的气溶胶递送的制剂治疗支气管内感染的方法。

    NITROIMIDAZOLE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF
    6.
    发明公开
    NITROIMIDAZOLE ANTIBACTERIAL COMPOUNDS AND METHODS OF USE THEREOF 失效
    抗菌硝基咪唑AND METHOD FOR USE

    公开(公告)号：EP0866793A1

    公开(公告)日：1998-09-30

    申请号：EP96923447.0

    申请日：1996-06-25

    申请人： PATHOGENESIS CORPORATION

    发明人： BAKER, William, R. ,  SHAOPEI, Cai ,  KEELER, Eric, L.

    IPC分类号： A61K31 ,  A61P31 ,  C07D487 ,  C07D498

    CPC分类号： C07D487/04 ,  Y02A50/488

    摘要： Methods, compounds and compositions are provided for inhibiting the growth of pathogenic mycobacteria in vitro and of treatment of pathogenic bacterial infections, such as mycobacterial and clostridium infections, in vivo using bicyclic nitroimidazole compounds of the formula (II): (II) wherein R1 is hydrogen, halogen, loweralkyl, haloloweralkyl, cycloalkyl, heterocycle, substituted heterocycle and heterocyclicalkyl; X is oxygen, sulfur or NK2, where R2 is hydrogen, loweralkyl, aryl, cycloalkyl, heterocycle, substituted heterocycle, heterocyclicalkyl, COR3 or SO2R4CONR4R5, where R4 and R5 are independently selected from hydrogen, loweralkyl, aryl, alkylaryl, alkoxyalkyl, alkoxyaryl, alkoxyalkoxyaryl, alkylheterocycle, and alkoxyheterocycle; n is 1, 2 or 3; Y and Z are independently selected CH2, CO, CR4R5 or NR4, where R4 and R5 are as defined above; provided that when n is 2 or 3, the compounds of formula II can be additionally substituted as follows: (IIa) (IIb) wherein R6, R7, R8 and R9 are independently selected from hydrogen, loweralkyl, aryl, alkylaryl, alkoxyalkyl, alkoxyaryl, alkoxyalkoxyaryl, alkylheterocycle, and alkoxyheterocycle; and the pharmaceutically acceptable salts thereof. The methods, compounds and compositons are particularly useful for inhibiting the growth of Mycobacterium tuberculosis and Clostridium difficile.

    MICOBACTERIAL REPORTER STRAINS AND USES THEREOF
    9.
    发明公开
    MICOBACTERIAL REPORTER STRAINS AND USES THEREOF 失效
    分枝杆菌记者菌株及其用途

    公开(公告)号：EP0784700A1

    公开(公告)日：1997-07-23

    申请号：EP95935267.0

    申请日：1995-10-02

    申请人： PATHOGENESIS CORPORATION

    发明人： STOVER, Kendall ,  HICKEY, Mark Jeffrey

    IPC分类号： C12N9 ,  C12N15 ,  C12Q1

    CPC分类号： C12N9/0069 ,  C12N15/74 ,  C12Q1/02 ,  C12Q1/6897

    摘要： This invention relates to a method of quantifying bacteria in vivo or in vitro using bacterial reporter strains. In particular this invention provides a method utilizing mycobacterial reporter strains that permits rapid screening for in vivo antimycobacterial activity of various compositions. In addition this invention provides for particular mycobacterial reporter strains expressing the FFlux gene at levels sufficiently high to allow detection in tissue homogenates without lysis or concentration of the bacteria.